Protein Alignment PPP1R9A and Spn

DIOPT Version :10

• Sequence 1: XP_047276529.1
• Gene: PPP1R9A / 55607
• HGNCID: 14946
• Length: 1403
• Species: Homo sapiens
• Sequence 2: NP_001246578.1
• Gene: Spn / 46194
• FlyBaseID: FBgn0010905
• Length: 2148
• Species: Drosophila melanogaster
• Alignment Length: 1395
• Identity: 366/1395 - (26%)
• Similarity: 588/1395 - (42%)
• Gaps: 368/1395 - (26%)

Human   197 AVSPTVSQLSAVFENTDSPSAIISEKAENNEYSVTGHYPLNLPSVTVTNLDTFGHLKDSNSWPPS 261
            |.|||  .:..:.|:....|| ::..|.|.|..:   ....:|::...:.|      :...:|..
  Fly   915 ATSPT--SIKNLIEDLPGQSA-VAASAANGEQDI---QIAAVPAIVEEDED------EEEDFPED 967

Human   262 NK----------RGVDTE-DAHKSNATPVPEVASKSTSL-ASIPGEEIQQSKEPEDSTSNQQTPD 314
            ::          .|.|.: |:....|..:......||:| |:....:   |.|.|.:|:...|..
  Fly   968 DEEDHARADFDANGGDADGDSDDVEAVDIVGYGHASTALNATFVKAD---STETETTTTTPSTAT 1029

Human   315 SI----DKDGPE--EPCAESKAMPKSEIPSPQSQLLEDAEANLVGREAAKQQRKELAGG-DFTSP 372
            :.    |.|.||  ....|:   ||..:   ::.|:..|.::     .|..||:||..| |....
  Fly  1030 TATTRHDDDEPEWLRDVLEA---PKRSL---ENLLITSATSS-----RAPGQREELENGYDLHEK 1083

Human   373 DASASSC----GKEVPEDSNNFDGSHVYMHSDYNVYR--------VRSRYNSDWGETGTEQDEEE 425
            .:..:..    |:.:.|...:.:.:    .||..:.:        :.|::||.:.....||....
  Fly  1084 HSDLNQTYITGGESLHESIVSVEST----QSDATLNQTTTIDDSIISSKHNSTYSLADAEQATSS 1144

Human   426 --------DSDENSYYQPDME---------------------YSEIVGLPEEEE---------IP 452
                    :.|::.||.|:..                     :.|:.||.:.::         :.
  Fly  1145 TVLSTGVTELDDSQYYIPEYPPVRSKEVLVEAGVHYFEDGNFWMEVPGLLDFDDDDCSYPPITVR 1209

Human   453 ANRKIKFSSAPIKVFNTYSNEDYDRRNDEVDPVAASAEYELEKRVEKLELFPVELEKDEDGLGIS 517
            .|.|::|||.||.|::|:|..||||||::||||||||||||||||||:.:|||||.|..:|||:|
  Fly  1210 KNPKVRFSSGPIHVYSTFSVNDYDRRNEDVDPVAASAEYELEKRVEKMHVFPVELMKGPEGLGLS 1274

Human   518 IIGMGVGADAGLEKLGIFVKTVTEGGAAQRDGRIQVNDQIVEVDGISLVGVTQNFAATVLRNTKG 582
            |||||||||||||||||||||:|:.|||.|||||||||||:||||.|||||||.:||:|||||.|
  Fly  1275 IIGMGVGADAGLEKLGIFVKTITDNGAAARDGRIQVNDQIIEVDGKSLVGVTQAYAASVLRNTSG 1339

Human   583 NVRFVIGREKPGQVSEVAQLISQTLEQERRQRELLEQHYAQYDADDDEVAMEDFNKSLRQSALFH 647
            .|:|.||||:..:.|||||||..:|:.:|.:.|.|::...:|               ||::
  Fly  1340 LVKFQIGRERDPENSEVAQLIRLSLQADREKEERLKRQQEEY---------------LRRT---- 1385

Human   648 DTRGNTVAELQGMSGNCNNNNNYFLKTGEYATDEEEDEVGPVLPGSDMAIEVFELPENEDMFSPS 712
                                           .|..||...||...|.:.         |...||.
  Fly  1386 -------------------------------LDYSEDSTQPVSANSSVC---------EGPSSPV 1410

Human   713 ELDTSKLSHKFKELQIKHAVTEAEIQKLKTKLQAAENEKVRWELEKTQLQQNIEENKERMLKLES 777
            :::     |.. |::..|:   .|::.||..||.:|    ...|.|.::.||:   |.:::|||:
  Fly  1411 QVE-----HPM-EVEATHS---QEVESLKRLLQESE----MGCLVKEEIIQNL---KRKLVKLET 1459

Human   778 YWIEAQTLCHTVNEH-----------------LKETQSQYQALEKKYNKAKKLIKDFQQKELDFI 825
            ...|.:.|...:.:.                 |:::|.||.||:|||||||:|::::||:|||..
  Fly  1460 TGNENELLSERLRQSERELGNIRKEAANLQNMLQQSQGQYMALDKKYNKAKRLVREYQQRELDMC 1524

Human   826 KRQEAERKKIEDLEKAHLVEVQGLQVRIRDLEAEVFRLLKQNGTQV------------------N 872
            .|:|..::.:::.:..:...|:.|:.|:.:||.|:....::.|..|                  .
  Fly  1525 HREEFYQQLLQEKDTEYNALVKKLKDRVINLEHELQETQRKAGFPVGLPYDSATLKLTPQMMRKT 1589

Human   873 NNNNIFER-RTSLGEVSKGDTMENLDGKQTSCQD---GLSQDLNEAVPETERLDSKALKTRAQLS 933
            ....:|.: .|.|.:....|...:.||.:|:..:   .:..:|:.|||:.|.||:...||:..|:
  Fly  1590 PPKPLFHKLETELSDTEISDLSPDGDGVKTATVERKVPVKDELDAAVPQHELLDNSINKTKIDLA 1654

Human   934 VKN---RRQRPSRTRLYDSVSSTDGE----------DSLERKPSNSFYNHMHITKLLPPKGLRTS 985
            .:.   .||.||..   .:.|:::|.          :.|:|..|||..:...:..        |.
  Fly  1655 SRGGLANRQLPSAN---GNSSTSNGAAVDLGQLSNGNLLKRSRSNSRSSDCTLDD--------TD 1708

Human   986 SPESDSGV------PPLTPVDSNVPFSSDHIAE-----FQEEPLDPEMGPLSSMWGDTSLFSTSK 1039
            ..|...|.      .|:.....::...:.|:..     .|..|  |.|         .::.:|..
  Fly  1709 EEEEREGSALNLAGAPVAHETISLSNGNSHLLANVNNLLQHHP--PAM---------ATVIATPS 1762

Human  1040 SDHDVEESPCHHQTTNKKILREKDDAKDPKSLRASSSLAVQGGKIKRKFVDLGAPLRRNSSKGKK 1104
            :.|....:|....:|:.                ||||.:.|....:.:...|.|.:.::.||.:.
  Fly  1763 NGHLGTTTPILLNSTSS----------------ASSSSSNQSTAREAQINQLYAQVHKDPSKQQH 1811

Human  1105 WKEKEKEASRFSAGSRI-------------------FRGRLENWTPKPCSTAQTSTRS------- 1143
            .::::::....:..:.|                   .||.:..:...|.:::.....|
  Fly  1812 QQQQQQQQQAQAVTTSIPSIFKNALGSPADNGLNDFHRGSMTTFGTGPATSSNRDLNSSYDSILG 1876

Human  1144 ---------PCMPFSWFNDSRK-----GSYSFRNLPAPTSSLQPSPETLISDK---------KGS 1185
                     |..  ||...||:     ||    .:|.|.||........:||:         :.|
  Fly  1877 SNDKLAENDPAE--SWMYPSRRRVAPNGS----KVPLPGSSFTDQLNQALSDRERRLGDGSSRHS 1935

Human  1186 KVENTWITKA-------------------NKRNPN-----PSSSSIFGRHSQLMSVVWIQETNNF 1226
            ..:.|.|.|:                   |:..|.     |.|.|..|      :|.| |:.::.
  Fly  1936 SDDYTEINKSQSAAAINCKTLINEIRQAVNEAQPKVKQVVPQSLSPPG------TVPW-QQQHHQ 1993

Human  1227 TFNDDFSPSSTSSADLSGLGAEPKTPGLSQSLALS-SDESLDMIDDEILDDGQSPKHSQCQNRAV 1290
            ......|..:|.....:.:.:...:||.|.|..|. |..|....|.:.:..|.:.|     ...|
  Fly  1994 QIQQQPSAHTTGPPSPTSMSSGCSSPGYSPSRTLDLSGSSSSFSDRKAMAAGYTYK-----GGPV 2053

Human  1291 QEWSVQQVSHWLMSLNLEQYVSEFSAQNITGEQLLQLDGNKLKALGMTASQDRAVVKKKLKEMKM 1355
            .||:..||.||||.:.||:|:..|...|:.|..||.||....|.||: ...|:..:||:||::|.
  Fly  2054 HEWTKDQVGHWLMGIELERYIPVFKENNVEGGALLTLDSKDFKTLGI-CGDDKHRLKKRLKDLKA 2117

Human  1356 SLEKARKAQEKMEKQREKLRRKEQEQMQRK 1385
            ::||.||..|:..::|||..||.:::..:|
  Fly  2118 NIEKERKDMERERREREKAIRKAEKKAAKK 2147

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP1R9A	XP_047276529.1	PDZ_5	434..497	CDD:465518	34/92 (37%)
		PDZ_neurabin-like	501..590	CDD:467252	68/88 (77%)
		CtpA	522..>685	CDD:440556	73/162 (45%)
		DR0291	713..>866	CDD:441187	46/169 (27%)
		SAM_Neurabin-like	1287..1356	CDD:188911	28/68 (41%)
Spn	NP_001246578.1	PDZ_5	1182..1254	CDD:465518	33/71 (46%)
		PDZ_neurabin-like	1258..1347	CDD:467252	68/88 (77%)
		SMC_N	<1344..1606	CDD:481474	78/336 (23%)
		CENP-F_leu_zip	1424..1535	CDD:463102	37/117 (32%)
		SAM_Neurabin-like	2050..2118	CDD:188911	28/68 (41%)