DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment KIF21A and KIP1

DIOPT Version :9

Sequence 1:NP_001365368.1 Gene:KIF21A / 55605 HGNCID:19349 Length:1675 Species:Homo sapiens
Sequence 2:NP_009490.1 Gene:KIP1 / 852216 SGDID:S000000159 Length:1111 Species:Saccharomyces cerevisiae


Alignment Length:1292 Identity:312/1292 - (24%)
Similarity:521/1292 - (40%) Gaps:364/1292 - (28%)


- Green bases have known domain annotations that are detailed below.


Human     4 APDESSVRVAVRIRPQLAKEKIEGCHICTS----------VTPGEPQVFLGKDKAFTFDYVFDID 58
            |..:|::.|.||.|.:..:|..|...:..|          ::.|..|.:....|.:.||.||..:
Yeast    47 ATSDSNIHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAE 111

Human    59 SQQEQIYIQCIEKLIEGCFEGYNATVFAYGQTGAGKTYTMGTGFDVNI-----------VEEELG 112
            |.||.::....:..|:....|||.|:|||||||.||||||..  |:||           :.|..|
Yeast   112 SDQETVFNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSG--DINILGDVQSTDNLLLGEHAG 174

Human   113 IISRAVKHLFKSIEEKKHIAIKNGLPAPDFKVNAQFLELYNEEVLDLFDTTRDID--AKSKKSNI 175
            ||.|.:..|||.:....          .::.|...|||||||.:.||...:.|.|  ....|..|
Yeast   175 IIPRVLVDLFKELSSLN----------KEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQI 229

Human   176 RI--HEDSTGGIYTVGVTTRTVNTESEMMQCLKLGALSRTTASTQMNVQSSRSHAIFTIHVCQTR 238
            ||  :.::...|...|:....:|:..|.:..|..|:|.|..|:|:.|..|||||.:|||   .|.
Yeast   230 RIFDNNNNNSSIMVKGMQEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTI---TTN 291

Human   239 VCPQIDADNATDNKIISESAQMNEFETLTAKFHFVDLAGSERLKRTGATGERAKEGISINCGLLA 303
            :..|...|:..:...:.           ..|.:.|||||||.:.|:||..:||:|...||..||.
Yeast   292 IVEQDSKDHGQNKNFVK-----------IGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLT 345

Human   304 LGNVISALGDKSKRATHVPYRDSKLTRLLQDSLGGNSQTIMIACVSPSDRDFMETLNTLKYANRA 368
            ||.||:||.|.|   .|:|||:|||||||||||||.::|.:||.:||:.....||.:||:||.||
Yeast   346 LGRVINALVDHS---NHIPYRESKLTRLLQDSLGGMTKTCIIATISPAKISMEETASTLEYATRA 407

Human   369 RNIKNKVMVNQDRAS--------QQINALRSE-----------ITRLQMELMEYKTGKRIIDEEG 414
            ::|||...|||..:.        |:|..||::           ||:.|::|  |::...:|||:.
Yeast   408 KSIKNTPQVNQSLSKDTCLKDYIQEIEKLRNDLKNSRNKQGIFITQDQLDL--YESNSILIDEQN 470

Human   415 VESINDMFHENAMLQTENNNLRVRIKAMQETVDALRSRITQLVSDQANHVLARAGEGNEEISNMI 479
            ::.               :|||.:||..:|      :.:.||                 :|:|::
Yeast   471 LKI---------------HNLREQIKKFKE------NYLNQL-----------------DINNLL 497

Human   480 HSYIKEIEDLRAKLLESEAVNENLRKNLTRATARAPYFSGSSTFSPTILSSDKETIEIIDLAKKD 544
            .|.       :.||:   |:.:|...:.:.      ::|.......|.|....|.|:..|.:.::
Yeast   498 QSE-------KEKLI---AIIQNFNVDFSN------FYSEIQKIHHTNLELMNEVIQQRDFSLEN 546

Human   545 LEKLKRKEKRKKKRL--QKLEESNREERSVAGKEDNTDTDQEKKEEKGVSERENNELEVEESQEV 607
            .:|.....:..:.::  |.|:..|..:.|:     |....:..:..|||:|        |.::.|
Yeast   547 SQKQYNTNQNMQLKISQQVLQTLNTLQGSL-----NNYNSKCSEVIKGVTE--------ELTRNV 598

Human   608 SDHEDEEEEEEEEEDDIDGGESSDESDSESDEKANYQA---DLANITCEIAIKQ--KLI------ 661
            :.|                             ||.:.:   .|.|||..:.:.|  :|:      
Yeast   599 NTH-----------------------------KAKHDSTLKSLLNITTNLLMNQMNELVRSISTS 634

Human   662 ------DELENSQKRLQTLKKQYEEKLMMLQHKIRDTQLERDQVLQNLGS--VESYSEEKAKKVR 718
                  |...:.:|.|..:.:.:::.|..||:.|:       ..|.::||  :.|.:|     :.
Yeast   635 LEIFQSDSTSHYRKDLNEIYQSHQQFLKNLQNDIK-------SCLDSIGSSILTSINE-----IS 687

Human   719 SEYEKKLQAMNKELQRLQAAQKEHARLLKNQSQYEKQLKKLQQDVMEMKKTKVRLMKQMKEE--- 780
            ......|.:||..::..|:..   ::|:|.|   :.::|||:.|::..::...:..:|:.|.   
Yeast   688 QNCTTNLNSMNVLIENQQSGS---SKLIKEQ---DLEIKKLKNDLINERRISNQFNQQLAEMKRY 746

Human   781 -QEKARLTES----RRNREIAQLKKDQRKRDHQLRLLEAQKRNQE--VVLRRKTEEVTALRRQVR 838
             |:....|.|    ..|:.|..||..|.|.|..:....|...|:.  ||.:..::.:.:|.....
Yeast   747 FQDHVSRTRSEFHDELNKCIDNLKDKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAE 811

Human   839 PMSDKVAGKVTRKLSSSDAPAQDTGSSAAAVETDASRTGAQQKMRIPVARVQALP---------- 893
            .....|:       .::::...|..|.:..:..|.|            :::::||          
Yeast   812 NTLKTVS-------QNNESFTNDLISLSRGMNMDIS------------SKLRSLPINEFLNKISQ 857

Human   894 ----------TPATN---GNRKKYQRKGLTGRVFISKTARMKWQLLERRVTDIIMQKMTISNMEA 945
                      |.|:|   .:.||:|                          :||...:.::|   
Yeast   858 TICETCGDDNTIASNPVLTSIKKFQ--------------------------NIICSDIALTN--- 893

Human   946 DMNRLLKQREELTKRREKLSKRREKIVKENGEGDKNVANINEEMESLTANIDYINDSISDCQANI 1010
              .:::...:|:..:.|.:|          .|.:.|:..|||...||      .|..::|...||
Yeast   894 --EKIMSLIDEIQSQIETIS----------NENNINLIAINENFNSL------CNFILTDYDENI 940

Human  1011 MQMEEAKEEGETLDVTAVINACTLTEARYLL--DHFLSMGINKGL-QAAQKEAQ-IKVLE--GRL 1069
            ||:.:.::|       .:...|...::..:|  |.|.:..|.|.| :..:.||. ||.|.  ...
Yeast   941 MQISKTQDE-------VLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVIKALPLLDYP 998

Human  1070 KQTEITSATQNQLLFHMLKEKAELNPELDALLGHALQDLDSVPLENVEDST-----DEDAP---- 1125
            ||.:|....:|       |.|.:.:.....:..  |...::.||......|     |:..|    
Yeast   999 KQFQIYRDAEN-------KSKDDTSNSRTCIPN--LSTNENFPLSQFSPKTPVPVPDQPLPKVLI 1054

Human  1126 ---LNS---------PGSEGSTLSSDLMKLCGEVKPKNKARRRTTTQMELLYADSSE 1170
               :||         |.:||:...|           :|..:||.||: .:|..:.:|
Yeast  1055 PKSINSAKSNRSKTLPNTEGTGRES-----------QNNLKRRFTTE-PILKGEETE 1099

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
KIF21ANP_001365368.1 KISc_KIF4 8..372 CDD:276823 141/388 (36%)
Cast <364..836 CDD:401982 104/521 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 556..641 12/86 (14%)
Smc <644..1004 CDD:224117 73/411 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 779..804 9/32 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 841..881 5/39 (13%)
Rcc_KIF21A 936..1017 CDD:410204 17/80 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1116..1138 8/42 (19%)
Interaction with KANK1 and KANK2. /evidence=ECO:0000269|PubMed:29183992 1146..1167 6/20 (30%)
WD40 1340..1653 CDD:238121
WD 1 1346..1383
WD 2 1386..1424
WD40 repeat 1391..1450 CDD:293791
WD 3 1450..1488
WD40 repeat 1456..1491 CDD:293791
WD 4 1491..1533
WD40 repeat 1496..1540 CDD:293791
WD 5 1542..1579
WD40 repeat 1548..1581 CDD:293791
WD 6 1583..1622
WD40 repeat 1588..1624 CDD:293791
WD 7 1625..1662
KIP1NP_009490.1 KISc_BimC_Eg5 50..419 CDD:276815 146/397 (37%)
235kDa-fam <423..>948 CDD:130673 126/706 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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