DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment kcnb2a and Shawl

DIOPT Version :9

Sequence 1:	XP_005163503.1	Gene:	kcnb2a / 555921	ZFINID:	ZDB-GENE-070912-170	Length:	824	Species:	Danio rerio
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	1029	Identity:	251/1029 - (24%)
Similarity:	382/1029 - (37%)	Gaps:	356/1029 - (34%)

- Green bases have known domain annotations that are detailed below.

Zfish    35 RVRINVGGLVHEVLWRTLDRLPRTRLGKLRDCNTHETLMEICDDYSLNDNEYFFDRHPGAFSSIL 99
            |:.:||.|:.:|....||.::|.|||.:         |.|...:|....||||||||||.|:.||
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSR---------LTEALANYDPVLNEYFFDRHPGVFTQIL 61

Zfish   100 NFYRTGKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQKKEQMN-----EELRREAETLR 159
            |:|||||||...::|...|.:||::||:|...:|.||.:.|...::..|     ::|..|.|...
  Fly    62 NYYRTGKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPT 126

Zfish   160 EKEGDQV----------DTGCCPDKRQKLWDLLEKPSSSVAAKVLAIISILFIILSTIALSLNTL 214
            |::..::          :..|....:.|:|.:.::||||..||::|.:|:.||.:|.|:..|.|.
  Fly   127 EEQIARLFGFEEALSNGELNCWQRIKPKIWAMFDEPSSSTGAKIVAGMSVFFIFVSVISFCLKTH 191

Zfish   215 PELQV------------------------------------------------------------ 219
            |..:|
  Fly   192 PGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQYHQHSITPPSGSIGPTFRVTNYTSYSSG 256

Zfish   220 --------------------------------------------------IDEFGQSNDNPNLAH 234
                                                              |:.:||.::  ...:
  Fly   257 NFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEEKILGHNGRRKHGWIETYGQPHE--AFFY 319

Zfish   235 VEAVCIAWFTMEYLLRFLSSPNKWKFFKGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVV 299
            ||.||..||.:|.::|.:.|||.|:|.|.|:|:||..|.|.:|..:        :.:......::
  Fly   320 VELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTATLSFYTDV--------MQRMGEYTGLL 376

Zfish   300 QIFRIMRILRILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEK--DEDAT 362
            :.|.|:||:|:.||.|||.||:.|..|.:.|..||.||:.||.:||:.|:||.::|||  |....
  Fly   377 EAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVFFLVLGIVFFASLAYYAEKLQDNPDN 441

Zfish   363 KFTSIPASFWWATITMTTVGYGDIYPQTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE-Q 426
            :|.|||...|||.:|||||||||:.|:|..|..||.||.:||||.||||:|:||:|||.||.. |
  Fly   442 QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMFVGALCALAGVLTIALPVPVIVSNFSMFYSHTQ 506

Zfish   427 KRQEKAIKRREAL----ERAKRN------------------------GSIVSMN----------- 452
            .|.:...|||..|    .|.||.                        |.:|.:.
  Fly   507 ARSKLPKKRRRVLPVEQPRRKREPTAPHRGRTNAIKQTPPTGPGLVAGGVVPVGAGGPGLGGHAV 571

Zfish   453 ---------LKDAFAR------NMELLDVVIEKNEDKA------ADNHLSPSRWNYQKNPNSELG 496
                     .||||..      |:..::|:......:.      |.|...|:       |.|.|
  Fly   572 GHSAAGAPMFKDAFGGAKIGTVNVNGVNVIGLHPAQRTTTTMAMAMNEADPT-------PMSAL- 628

Zfish   497 SKGFDSKYQEVGQLASPERVFRSTPSPQRL------NAKSLEQMYNQMTAASSMSSSGPSASKVS 555
                  .||        ..:.:.||:|...      :|..|......||:::|::.|..||: |:
  Fly   629 ------TYQ--------VPMLQPTPTPAHSHGHAHGHAHGLGPASAAMTSSASLTGSAASAA-VA 678

Zfish   556 TVVGREEEMEMKVVQCEPRLKEKPVTEIRSLSSVDSFASCATDISEVERSALLPNFAG------R 614
            |...           ..|.......::..|:.:|.|....|..........|.|...|      :
  Fly   679 TAAA-----------AAPAGPSFISSDYLSVPAVQSLQPRAATTGHDFMLPLQPKLLGPLERKDQ 732

Zfish   615 HP----------------------------------RAPPPLDLSQITSLEKRAKQPTIIKEGLY 645
            ||                                  ..||.|.:|       ..:.|
  Fly   733 HPLQLTAHNLASDTHQLMYSGHAHSQHKVGGGAAVLNVPPTLSMS-------HTQMP-------- 782

Zfish   646 EFVPCKSDGSSTMSQGEENQSFDQSDENVRSPPQGNQVKLKGLKVNFTES-AEEGASNLHLVVTD 709
                   .|.::|.|...|.||        .|..|...::..::.....| |...::|.::.::.
  Fly   783 -------PGIASMGQRTPNLSF--------RPAHGASSQVATVQQPIPHSHACHASTNCNIKISV 832

Zfish   710 DVATL---------TPKVPVSDPLLLAGSPRQSPRATEGDGATSSPG--FSLSSSESQRGRNHVD 763
            ..|.|         ||||.:.|.|           :.:.:.:|...|  ..:..|::..|
  Fly   833 ASAGLSVGCPDEFRTPKVTLLDDL-----------SDDVNSSTDDCGDCCLVDDSDTYEG----- 881

Zfish   764 RAAVTPTSPKSAQNCASATAGAVGAEDNIQSGQKVDNHLLSPDILKSSGDGGRS 817
              ......|...:|...    |:|.:|.:     :||.....:..:.||.||.|
  Fly   882 --TTINNGPSGQENGTE----AIGLDDGL-----LDNDGEDEEDGEGSGVGGDS 924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kcnb2a	XP_005163503.1	BTB	36..142	CDD:197585	45/105 (43%)
		BTB_2	36..135	CDD:280393	42/98 (43%)
		Ion_trans	229..427	CDD:278921	90/200 (45%)
		Ion_trans_2	340..421	CDD:285168	47/82 (57%)
		Kv2channel	473..695	CDD:281514	44/273 (16%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	43/100 (43%)
		BTB_2	7..97	CDD:280393	42/98 (43%)
		Ion_trans	307..506	CDD:278921	93/208 (45%)
		Ion_trans_2	<449..499	CDD:285168	31/49 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2126
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810