DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment KIF27 and KIP3

DIOPT Version :9

Sequence 1:	XP_011517150.1	Gene:	KIF27 / 55582	HGNCID:	18632	Length:	1427	Species:	Homo sapiens
Sequence 2:	NP_011299.1	Gene:	KIP3 / 852655	SGDID:	S000003184	Length:	805	Species:	Saccharomyces cerevisiae

Alignment Length:	776	Identity:	229/776 - (29%)
Similarity:	351/776 - (45%)	Gaps:	196/776 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    33 NSQQVIIGRDRVFTFDFVFGKNSTQDEVYNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGGG 97
            :||:...|.:..|.||.:|.:.|:|..||.....||:.|:::|:|:||||||.||.|||||:.|
Yeast   141 SSQRRRHGGEIKFVFDKLFDETSSQARVYKETTSPLLDSVLDGFNSTVFAYGATGCGKTYTVSG- 204

Human    98 HIASVVEGQKGIIPRAIQEIFQSISE-HPSIDFNVKVSYIEVYKEDLRDLLELETSMKDLHIRED 161
                 ...|.|||..|::|:|..|:: ....||.:.:||:|:|.|.:||||:.||..|.|.||||
Yeast   205 -----TPSQPGIIFLAMEELFNKITDLKDEKDFEISLSYLEIYNERIRDLLKPETPSKRLVIRED 264

Human   162 EKGNTVIVGAKECHVESAGEVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAE 226
            .:.:..:......|..:..:||.|:..||..|.|..|:.||.||||||:..|.|.|.:|.::
Yeast   265 TQNHIKVANLSYHHPNTVEDVMDLVVQGNINRTTSPTEANEVSSRSHAVLQIHIMQTNKLVD--- 326

Human   227 DGSWYSPRHIVSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISA--LGDPRRKSS 289
                .:.:|..:....:|||||||...|.|.|.|..|...||..||||||.|:|  |.|..| |.
Yeast   327 ----LTSQHTFATLSIIDLAGSERAAATRNRGIRLHEGANINRSLLALGNCINALCLNDGSR-SC 386

Human   290 HIPYRDAKITRLLKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESD 354
            ||||||:|:|||||.||||:.|||||.|:|||||::||:||:|||||||:.|:.|
Yeast   387 HIPYRDSKLTRLLKFSLGGNCKTVMIVCISPSSSHYDETLNTLKYANRAKEIKTK---------- 441

Human   355 RIDEMEFEIKLLREALQSQQAGVSQTTQINREGSPDTNRIHSLEEQVAQLQGECLGYQCCVEEAF 419
                          .:::||:       ::|........|...:.|:.:|:..        ||.
Yeast   442 --------------IIRNQQS-------LSRHVGSYLKMITEQKRQIEELRER--------EEK- 476

Human   420 TFLVDLKDT-VRLN-EKQQHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQHVTVLQLKREL 482
              ::.||.| .:|| ||.|..:.|..|.:|:....|.|                    .|:.:.|
Yeast   477 --MISLKLTKYKLNKEKIQLAINECVNRVQQTYAGVET--------------------YQVAKTL 519

Human   483 KK---C-----QCV-LAADEVV--FNQKELEVKELK---NQVQMMVQE--NKGHAVSLKEAQKVN 531
            |.   |     |.| |..|.::  |.::|....|::   :..:|:..:  ||.|.:.:|
Yeast   520 KSLILCKRRFLQMVKLEVDNLILLFEREESTAAEMQPVISNCRMISGQLYNKIHELEMK------ 578

Human   532 RLQPLAKTTLLST------SMDLPILNISYNWNHTNEKIIEQQLLVDQLSEELTKLNLSVTSSAK 590
                ..:|..||:      |:||..|....:|:.|.:.:..:..| :|:| ||.:..:.|.||..
Yeast   579 ----FDETDTLSSVIHQVHSIDLNKLREMEDWDETYDLVYLESCL-NQIS-ELQRNEILVNSSIM 637

Human   591 ENCGDGPDARIPERRPYTVPFDTHLGHYIYIPSRQDSRKVHTSPPMYSLDRIFAGFRTRSQMLLG 655
                                                :.|:.:.|.:.|      .|:..|:.|:.
Yeast   638 ------------------------------------TEKLMSDPGLNS------RFKFLSKWLMN 660

Human   656 ---HIEE--QDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDS----------VCSLVEL 705
               :||.  || ::|.       |||.|.        .:|::|..|||          ..:..:|
Yeast   661 RTPNIESIIQD-LVHI-------DEEFES--------FARTFIANPDSNFTNTNINIINTTAADL 709

Human   706 SDTQDETQKSDLENEDLK--------IDCLQESQELNLQKLKNSERILTEAKQKMRELTIN 758
            :...:..|:.:...:.:|        ...::...||..:..::.:.|.:|....|::.|.|
Yeast   710 AVPAETLQRQNFSQKKVKWTSPDLSPSPMIEPQPELEPELHQDQDAIASEVDVSMQDTTFN 770

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
KIF27	XP_011517150.1	KISc_KIF4	4..342	CDD:276823	143/311 (46%)
		KISc	5..348	CDD:214526	145/317 (46%)
		COG1340	820..1077	CDD:224259
		DUF4200	826..>910	CDD:290574
KIP3	NP_011299.1	KISc_KIP3_like	82..438	CDD:276821	143/310 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910