Protein Alignment KIF27 and KIP1

DIOPT Version :10

• Sequence 1: XP_011517150.1
• Gene: KIF27 / 55582
• HGNCID: 18632
• Length: 1427
• Species: Homo sapiens
• Sequence 2: NP_009490.1
• Gene: KIP1 / 852216
• SGDID: S000000159
• Length: 1111
• Species: Saccharomyces cerevisiae
• Alignment Length: 1229
• Identity: 294/1229 - (23%)
• Similarity: 502/1229 - (40%)
• Gaps: 326/1229 - (26%)

Human     6 VKVAVRIRPLLCKEALHNHQVCVRVI-PNSQQVIIGR---------DRVFTFDFVFGKNSTQDEV 60
            :.|.||.|....:|......|.:..: |..:::|:..         .:.:.||.|||..|.|:.|
Yeast    53 IHVYVRCRSRNKREIEEKSSVVISTLGPQGKEIILSNGSHQSYSSSKKTYQFDQVFGAESDQETV 117

Human    61 YNTCIKPLVLSLIEGYNATVFAYGQTGSGKTYTIGG-----GHIAS----VVEGQKGIIPRAIQE 116
            :|...|..:..::.|||.|:|||||||:|||||:.|     |.:.|    ::....|||||.:.:
Yeast   118 FNATAKNYIKEMLHGYNCTIFAYGQTGTGKTYTMSGDINILGDVQSTDNLLLGEHAGIIPRVLVD 182

Human   117 IFQSISEHPSIDFNVKVSYIEVYKEDLRDLLE--------LETSMKDLHIREDEKGNTVIV--GA 171
            :|:.:|. .:.:::||:|::|:|.|:|:|||.        :....:.:.|.::...|:.|:  |.
Yeast   183 LFKELSS-LNKEYSVKISFLELYNENLKDLLSDSEDDDPAVNDPKRQIRIFDNNNNNSSIMVKGM 246

Human   172 KECHVESAGEVMSLLEMGNAARHTGTTQMNEHSSRSHAIFTISICQVHKNMEAAEDGSWYSPRHI 236
            :|..:.||.|.::||..|:..|....|:.|:.|||||.:|||:...|.::   ::|.........
Yeast   247 QEIFINSAHEGLNLLMQGSLKRKVAATKCNDLSSRSHTVFTITTNIVEQD---SKDHGQNKNFVK 308

Human   237 VSKFHFVDLAGSERVTKTGNTGERFKESIQINSGLLALGNVISALGDPRRKSSHIPYRDAKITRL 301
            :.|.:.|||||||.:.::|...:|.:|:..||..||.||.||:||.|   .|:|||||::|:|||
Yeast   309 IGKLNLVDLAGSENINRSGAENKRAQEAGLINKSLLTLGRVINALVD---HSNHIPYRESKLTRL 370

Human   302 LKDSLGGSAKTVMITCVSPSSSNFDESLNSLKYANRARNIRNKPTVNFSPESDR-IDEMEFEIKL 365
            |:|||||..||.:|..:||:..:.:|:.::|:||.||::|:|.|.||.|...|. :.:...||:.
Yeast   371 LQDSLGGMTKTCIIATISPAKISMEETASTLEYATRAKSIKNTPQVNQSLSKDTCLKDYIQEIEK 435

Human   366 LREALQSQQAGVSQTTQINREG------------------SPDTNRIHSLEEQVAQLQGECLGYQ 412
            ||..|::.:         |::|                  .....:||:|.||:.:.
Yeast   436 LRNDLKNSR---------NKQGIFITQDQLDLYESNSILIDEQNLKIHNLREQIKKF-------- 483

Human   413 CCVEEAFTFLVDLKDTVRLNEKQ------QHKLQEWFNMIQEVRKAVLTSFRGIGGTASLEEGPQ 471
               :|.:...:|:.:.:: :||:      |:...::.|...|::|.
Yeast   484 ---KENYLNQLDINNLLQ-SEKEKLIAIIQNFNVDFSNFYSEIQKI------------------- 525

Human   472 HVTVLQLKRELKKCQCVLAADEVVFNQKELEVKELKNQVQMMVQENKGHAVSLKEAQKVNRLQPL 536
            |.|.|:|..|             |..|::..::  .:|.|....:|....:|.:..|.:|.||.
Yeast   526 HHTNLELMNE-------------VIQQRDFSLE--NSQKQYNTNQNMQLKISQQVLQTLNTLQG- 574

Human   537 AKTTLLSTSMDLPILNISYNWNHTNEKIIEQQLLVDQLSEELTKLNLSVTSSAKENCGDGPDARI 601
                               :.|:.|.|..|   ::..::||||: |:: |..||.
Yeast   575 -------------------SLNNYNSKCSE---VIKGVTEELTR-NVN-THKAKH---------- 605

Human   602 PERRPYTVPFDTHLGHYIYIPS-------RQDSRKVHTSPPMYSLDRIFAGFRTRSQMLLGHIEE 659
                      |:.|...:.|.:       .:..|.:.||..::..|.     .:..:..|..|.:
Yeast   606 ----------DSTLKSLLNITTNLLMNQMNELVRSISTSLEIFQSDS-----TSHYRKDLNEIYQ 655

Human   660 QDKVLHCQFSDNSDDEESEGQEKSGTRCRSRSWIQKPDSVCSLVELSD---TQDETQKSDLENED 721
            .    |.||..|..::.....:..|:           ..:.|:.|:|.   |...:....:||:.
Yeast   656 S----HQQFLKNLQNDIKSCLDSIGS-----------SILTSINEISQNCTTNLNSMNVLIENQQ 705

Human   722 LKIDCLQESQELNLQKLK----NSERILTEAKQKMREL----------------------TINIK 760
            .....|.:.|:|.::|||    |..||..:..|::.|:                      ..|:|
Yeast   706 SGSSKLIKEQDLEIKKLKNDLINERRISNQFNQQLAEMKRYFQDHVSRTRSEFHDELNKCIDNLK 770

Human   761 MKEDLIKELI--KTGNDAKS----VSKQYSLKVTKLEHDAEQAKVELIETQKQLQELENKDL--- 816
            .|:..:.:.|  ||.:....    |:|.:|..:..|.|:||..    ::|..|..|....||
Yeast   771 DKQSKLDQDIWQKTASIFNETDIVVNKIHSDSIASLAHNAENT----LKTVSQNNESFTNDLISL 831

Human   817 -----SDVAMKVKLQ--KEFRKKMDAAKLRVQVLQKKQQDSKKLASLSIQNEKRANELEQSVDHM 874
                 .|::.|::..  .||..|:.      |.:.:...|...:||         |.:..|:  .
Yeast   832 SRGMNMDISSKLRSLPINEFLNKIS------QTICETCGDDNTIAS---------NPVLTSI--K 879

Human   875 KYQKIQLQRKLREENEKRKQLDAVIKRDQQKIKEI--QLKTGQEEGLKPKAEDLDACNLKRRKGS 937
            |:|.| :...:...|||...|          |.||  |::|...|         :..||.....:
Yeast   880 KFQNI-ICSDIALTNEKIMSL----------IDEIQSQIETISNE---------NNINLIAINEN 924

Human   938 FGSI------DHLQKLDEQKKWLDEEVEKVLNQRQELEELEADL-------------KKREAIVS 983
            |.|:      |:.:.:.:..|..||.:.:...:.|.|:.|..|:             .:.||.|.
Yeast   925 FNSLCNFILTDYDENIMQISKTQDEVLSEHCEKLQSLKILGMDIFTAHSIEKPLHEHTRPEASVI 989

Human   984 KKEALL------QEKSHLENKKLRSSQALNTDSLKISTRLNL-----------------LEQELS 1025
            |...||      |.....|||....:....|....:||..|.                 |.:.|.
Yeast   990 KALPLLDYPKQFQIYRDAENKSKDDTSNSRTCIPNLSTNENFPLSQFSPKTPVPVPDQPLPKVLI 1054

Human  1026 EKNVQLQTSTAEEKTKISEQVEVLQKEKDQLQKRRHNVD-----EKLKNGRVLSPEEEH 1079
            .|::   .|....::|.....|...:|.....|||...:     |:.:|..:|..::.|
Yeast  1055 PKSI---NSAKSNRSKTLPNTEGTGRESQNNLKRRFTTEPILKGEETENNDILQNKKLH 1110

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KIF27	XP_011517150.1	KISc_KIF4	4..342	CDD:276823	127/364 (35%)
		PTZ00121	<658..1227	CDD:173412	104/516 (20%)
KIP1	NP_009490.1	KISc_BimC_Eg5	50..419	CDD:276815	132/372 (35%)
		235kDa-fam	<423..>948	CDD:130673	127/685 (19%)
		AAA_13	<562..>741	CDD:463796	47/243 (19%)