DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STAB2 and Stab2

DIOPT Version :9

Sequence 1:	NP_060034.9	Gene:	STAB2 / 55576	HGNCID:	18629	Length:	2551	Species:	Homo sapiens
Sequence 2:	XP_038934441.1	Gene:	Stab2 / 282580	RGDID:	628822	Length:	2569	Species:	Rattus norvegicus

Alignment Length:	2565	Identity:	2024/2565 - (78%)
Similarity:	2252/2565 - (87%)	Gaps:	22/2565 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     2 MLQHLVIFCLGLVVQNFCSPAETTGQARRCDRKSLLTIRTECRSCALNLGVKCPDGYTMITSGSV 66
            ||..|:...|||||||.|||.|....|:|||:||.|||:|||:||:.|..|||||||..:||||.
  Rat    10 MLLPLIPLFLGLVVQNACSPTEGPELAKRCDKKSTLTIKTECQSCSANFAVKCPDGYIKVTSGSA 74

Human    67 GVRDCRYTFEVRTYSLSLPGCRHICRKDYLQPRCCPGRWGPDCIECPGGAGSPCNGRGSCAEGME 131
            |||||||:.::::|.|::||||||||||||||:||||.|||||:||||||.:||.|||.|.||||
  Rat    75 GVRDCRYSLDIQSYVLAIPGCRHICRKDYLQPQCCPGHWGPDCMECPGGARAPCGGRGVCDEGME 139

Human   132 GNGTCSCQEGFGGTACETCADDNLFGPSCSSVCNCVHGVCNSGLDGDGTCECYSAYTGPKCDKPI 196
            |.|:||||.||.|||||.||.||:|||:||:||:||||||||||:|||||||.|||.||||||||
  Rat   140 GTGSCSCQAGFSGTACEACATDNVFGPNCSAVCSCVHGVCNSGLNGDGTCECLSAYRGPKCDKPI 204

Human   197 PECAALLCPENSRCSPSTEDENKLECKCLPNYRGDGKYCDPINPCLRKICHPHAHCTYLGPNRHS 261
            ||||.||||||||||||::||.||:|||||||.|||..|.||||||:.||||||.|:||||||||
  Rat   205 PECATLLCPENSRCSPSSKDETKLQCKCLPNYEGDGHNCRPINPCLKTICHPHASCSYLGPNRHS 269

Human   262 CTCQEGYRGDGQVCLPVDPCQINFGNCPTKSTVCKYDGPGQSHCECKEHYQNFVPGVGCSMTDIC 326
            |.||:||:|||||||||||||.|:|.||.:||||||||||||||||||||:||||||||||||||
  Rat   270 CICQKGYQGDGQVCLPVDPCQTNYGKCPPESTVCKYDGPGQSHCECKEHYRNFVPGVGCSMTDIC 334

Human   327 KSDNPCHRNANCTTVAPGRTECICQKGYVGDGLTCYGNIMERLRELNTEPRGKWQGRLTSFISLL 391
            :|:||||:||||:||:||:|:|.||||||||||.||||||:|||||||||||.|||:||||||:|
  Rat   335 ESNNPCHKNANCSTVSPGKTKCTCQKGYVGDGLNCYGNIMQRLRELNTEPRGMWQGQLTSFISIL 399

Human   392 DKAYAWPLSKLGPFTVLLPTDKGLKGFNVNELLVDNKAAQYFVKLHIIAGQMNIEYMNNTDMFYT 456
            |:.||||||.|||||||||:||||||.:|.|||:|.:||:||.|||||||||::|.|.:.|.|||
  Rat   400 DRTYAWPLSNLGPFTVLLPSDKGLKGVDVKELLMDKEAARYFAKLHIIAGQMSMEQMYHLDTFYT 464

Human   457 LTGKSGEIFNSDKDNQIKLKLHGGKKKVKIIQGDIIASNGLLHILDRAMDKLEPTFESNNEQTIM 521
            ||||||||||.|||||:||||| |.|.||||||:|:|||||:|||||||||.||||.||.:||||
  Rat   465 LTGKSGEIFNKDKDNQLKLKLH-GSKVVKIIQGNIVASNGLVHILDRAMDKTEPTFASNPQQTIM 528

Human   522 TMLQPRYSKFRSLLEETNLGHALDEDGVGGPYTIFVPNNEALNNMKDGTLDYLLSPEGSRKLLEL 586
            .||||||.:||||||:||:|..|||   |||||||||:||||:|||...||||||||||||||||
  Rat   529 AMLQPRYGRFRSLLEKTNVGQILDE---GGPYTIFVPSNEALSNMKADILDYLLSPEGSRKLLEL 590

Human   587 VRYHIVPFTQLEVATLISTPHIRSMANQLIQFNTTDNGQILANDVAMEEIEITAKNGRIYTLTGV 651
            ||||||.|||||||||:|||||||||||:|:||.|..||||||:|||:|.|:.||||||||||||
  Rat   591 VRYHIVAFTQLEVATLVSTPHIRSMANQIIKFNITSKGQILANNVAMDETEVAAKNGRIYTLTGV 655

Human   652 LIPPSIVPILPHRCDETKREMKLGTCVSCSLVYWSRCPANSEPTALFTHRCVYSGRFGSLKSGCA 716
            ||||||:|||||||:|||.|:|||||||||..:||:|||:|:|..:|: .|.||.|..:||||||
  Rat   656 LIPPSILPILPHRCNETKIELKLGTCVSCSTKHWSKCPADSKPATIFS-SCFYSSRVRNLKSGCA 719

Human   717 RYCNATVKIPKCCKGFYGPDCNQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQFCSDP 781
            ||||.||:||:|||||:||||..|||||..||||||||.|.|.|||||||::|||||.|||||||
  Rat   720 RYCNVTVEIPRCCKGFFGPDCTPCPGGFLTPCSGNGQCMDGLAGNGTCICQDGFQGSMCQFCSDP 784

Human   782 NKYGPRCNKKCLCVHGTCNNRIDSDGACLTGTCRDGSAGRLCDKQTSACGPYVQFCHIHATCEYS 846
            |:||||||:.||||||||:||:|||||||:||||:|:|||.|||||||||||||||||||:||||
  Rat   785 NRYGPRCNRTCLCVHGTCDNRLDSDGACLSGTCREGTAGRFCDKQTSACGPYVQFCHIHASCEYS 849

Human   847 NGTASCICKAGYEGDGTLCSEMDPCTGLTP-GGCSRNAECIKTGTGTHTCVCQQGWTGNGRDCSE 910
            |.||||:|..||||||.|||:.|||.|||. ||||.|||||:|.|||::||||||||||||||..
  Rat   850 NKTASCVCNEGYEGDGVLCSKKDPCLGLTSRGGCSPNAECIQTSTGTYSCVCQQGWTGNGRDCVG 914

Human   911 INNCLLPSAGGCHDNASCLYVGPGQNECECKKGFRGNGIDCEPITSCLEQTGKCHPLASCQSTSS 975
            ||||||||:|||||||:|||||||||||||||||||||||||||.||||||.||||||:||||||
  Rat   915 INNCLLPSSGGCHDNATCLYVGPGQNECECKKGFRGNGIDCEPIISCLEQTEKCHPLATCQSTSS 979

Human   976 GVWSCVCQEGYEGDGFLCYGNAAVELSFLSEAAIFNRWINNASLQPTLSATSNLTVLVPSQQATE 1040
            |||||||:|||||:|.|||||..:|||||.|||:|.:||||||||..||.||||||||||::|.|
  Rat   980 GVWSCVCREGYEGNGVLCYGNVLMELSFLPEAAVFYQWINNASLQSVLSTTSNLTVLVPSRRAFE 1044

Human  1041 DMDQDEKSFWLSQSNIPALIKYHMLLGTYRVADLQTLSSSDMLATSLQGNFLHLAKVDGNITIEG 1105
            ||||:|||||||::|||||||||:|||.|.|||||.|||..|||||||||||.|.|.||||||||
  Rat  1045 DMDQNEKSFWLSRNNIPALIKYHILLGKYGVADLQALSSPHMLATSLQGNFLQLDKADGNITIEG 1109

Human  1106 ASIVDGDNAATNGVIHIINKVLVPQRRLTGSLPNLLMRLEQMPDYSIFRGYIIQYNLANAIEAAD 1170
            ||||||||||||||:|||||||||||.||||||:||.||||||.|||||||||.||||:||||||
  Rat  1110 ASIVDGDNAATNGVVHIINKVLVPQRGLTGSLPSLLTRLEQMPGYSIFRGYIIHYNLASAIEAAD 1174

Human  1171 AYTVFAPNNNAIENYIREKKVLSLEEDVLRYHVVLEEKLLKNDLHNGMHRETMLGFSYFLSFFLH 1235
            |||||.|||.||||||||||..||:||:|||||||.||||||||||||||||||||||.|:|||.
  Rat  1175 AYTVFVPNNEAIENYIREKKATSLKEDILRYHVVLGEKLLKNDLHNGMHRETMLGFSYLLAFFLR 1239

Human  1236 NDQLYVNEAPINYTNVATDKGVIHGLGKVLEIQKNRCDNNDTTIIRGRCRTCSSELTCPFGTKSL 1300
            ||||||||||||||||||||||||||.|||||||||||||||.|:||.|..||.:..||..||.|
  Rat  1240 NDQLYVNEAPINYTNVATDKGVIHGLEKVLEIQKNRCDNNDTIIVRGECGKCSQQAPCPLETKPL 1304

Human  1301 GNEKRRCIYTSYFMGRRTLFIGCQPKCVRTVITRECCAGFFGPQCQPCPGNAQNVCFGNGICLDG 1365
             .|.|:|||:.||||:|::||||||:||||:|||.|||||||||||.|||..||||.|||.||||
  Rat  1305 -RETRKCIYSIYFMGKRSVFIGCQPQCVRTIITRACCAGFFGPQCQACPGRGQNVCSGNGFCLDG 1368

Human  1366 VNGTGVCECGEGFSGTACETCTEGKYGIHCDQACSCVHGRCNQGPLGDGSCDCDVGWRGVHCDNA 1430
            |||||.|:||.||||||||||||||||||||||||||||||:||||||||||||||||||.||..
  Rat  1369 VNGTGTCQCGLGFSGTACETCTEGKYGIHCDQACSCVHGRCSQGPLGDGSCDCDVGWRGVKCDME 1433

Human  1431 TTEDNCNGTCHTSANCLTNSDGTASCKCAAGFQGNGTICTAINACEISNGGCSAKADCKRTTPGR 1495
            .|.||||||||||||||.:.||.|||||||||:||||:||||||||.||||||.||||||||||.
  Rat  1434 ITTDNCNGTCHTSANCLLDPDGKASCKCAAGFRGNGTVCTAINACETSNGGCSTKADCKRTTPGN 1498

Human  1496 RVCTCKAGYTGDGIVCLEINPCLENHGGCDKNAECTQTGPNQAACNCLPAYTGDGKVCTLINVCL 1560
            |||.||||||||||||||||||||||||||:||||||||||||.|||||.||||||||:||||||
  Rat  1499 RVCVCKAGYTGDGIVCLEINPCLENHGGCDRNAECTQTGPNQAVCNCLPKYTGDGKVCSLINVCL 1563

Human  1561 TKNGGCSEFAICNHTGQVERTCTCKPNYIGDGFTCRGSIYQELPKNPKTSQYFFQLQEHFVKDLV 1625
            |.|||||.||.||:|.|.:|.|||||:|.|||..||||||.||||||.|||||||||||.|::|.
  Rat  1564 TNNGGCSPFAFCNYTEQDQRICTCKPDYTGDGIVCRGSIYGELPKNPSTSQYFFQLQEHAVRELA 1628

Human  1626 GPGPFTVFAPLSAAFDEEARVKDWDKYGLMPQVLRYHVVACHQLLLENLKLISNATSLQGEPIVI 1690
            ||||||||||||::|:.|.|:||||:.|||.||||||||.|.||||:|||:.::||:|||||:.|
  Rat  1629 GPGPFTVFAPLSSSFNHEPRIKDWDQQGLMSQVLRYHVVGCQQLLLDNLKVTTSATTLQGEPVSI 1693

Human  1691 SVSQSTVYINNKAKIISSDIISTNGIVHIIDKLLSPKNLLITPKDNSGRILQNLTTLATNNGYIK 1755
            ||||.||:|||:||::|||||||||::|:||||||||||||||||..||:||||||:|.|:||.|
  Rat  1694 SVSQDTVFINNEAKVLSSDIISTNGVIHVIDKLLSPKNLLITPKDALGRVLQNLTTVAANHGYTK 1758

Human  1756 FSNLIQDSGLLSVITDPIHTPVTLFWPTDQALHALPAEQQDFLFNQDNKDKLKEYLKFHVIRDAK 1820
            ||.|||||||||||||.||||||:|||||:||.|||.||||||||||||||||.|||||||||:|
  Rat  1759 FSKLIQDSGLLSVITDSIHTPVTVFWPTDKALEALPPEQQDFLFNQDNKDKLKSYLKFHVIRDSK 1823

Human  1821 VLAVDLPTSTAWKTLQGSELSVKCGAGRDIGDLFLNGQTCRIVQRELLFDLGVAYGIDCLLIDPT 1885
            .||.|||.|.:|||||||||||:||.|.|||:||||.|.|||:||.||||:||||||||||:|||
  Rat  1824 ALASDLPRSASWKTLQGSELSVRCGTGSDIGELFLNEQMCRIIQRGLLFDVGVAYGIDCLLMDPT 1888

Human  1886 LGGRCDTFTTFDASGECGSCVNTPSCPRWSKPKGVKQKCLYN-LPFKRNLEGCRERCSLVIQIPR 1949
            ||||||||||||..||||||:.||.||..|||||||:||:|| |||:||:|||:..|:||||.||
  Rat  1889 LGGRCDTFTTFDIPGECGSCIFTPRCPLKSKPKGVKKKCIYNPLPFRRNVEGCQNLCTLVIQTPR 1953

Human  1950 CCKGYFGRDCQACPGGPDAPCNNRGVCLDQYSATGECKCNTGFNGTACEMCWPGRFGPDCLPCGC 2014
            ||.|||..||||||||||.||||||:|.|.|:..|:|.|:|||||||||:||.|||||||.||.|
  Rat  1954 CCHGYFMPDCQACPGGPDTPCNNRGMCRDLYTPMGQCLCHTGFNGTACELCWHGRFGPDCQPCSC 2018

Human  2015 SDHGQCDDGITGSGQCLCETGWTGPSCDTQAVLPAVCTPPCSAHATCKENNTCECNLDYEGDGIT 2079
            |:|||||:||||||:|||||||||..|||...:..||||.||.||||.|||||.|||:|||||:|
  Rat  2019 SEHGQCDEGITGSGECLCETGWTGRFCDTPTAVIPVCTPVCSVHATCTENNTCVCNLNYEGDGLT 2083

Human  2080 CTVVDFCKQDNGGCAKVARCSQKGTKVSCSCQKGYKGDGHSCTEIDPCADGLNGGCHEHATCKMT 2144
            |||||||||:||||||||:||||||:|||||:|||||||:||.||||||||:||||||||||:||
  Rat  2084 CTVVDFCKQNNGGCAKVAKCSQKGTQVSCSCKKGYKGDGYSCIEIDPCADGVNGGCHEHATCRMT 2148

Human  2145 GPGKHKCECKSHYVGDGLNCEPEQLPIDRCLQDNGQCHADAKCVDLHFQDTTVGVFHLRSPLGQY 2209
            |||||||||||||||||::|||||||:|||||||||||.||.|.|||||||||||||||||||||
  Rat  2149 GPGKHKCECKSHYVGDGVDCEPEQLPLDRCLQDNGQCHPDASCADLHFQDTTVGVFHLRSPLGQY 2213

Human  2210 KLTFDKAREACANEAATMATYNQLSYAQKAKYHLCSAGWLETGRVAYPTAFASQNCGSGVVGIVD 2274
            |||||||:||||.||||:|||||||||||||||||||||||:|||||||.:|||.||:.||||||
  Rat  2214 KLTFDKAKEACAKEAATIATYNQLSYAQKAKYHLCSAGWLESGRVAYPTTYASQKCGANVVGIVD 2278

Human  2275 YGPRPNKSEMWDVFCYRMKDVNCTCKVGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAYSNSSA 2339
            ||.|.|||||||||||||||||||||.||||||||||||||||||||||||||||||||:|.|||
  Rat  2279 YGSRANKSEMWDVFCYRMKDVNCTCKAGYVGDGFSCSGNLLQVLMSFPSLTNFLTEVLAFSKSSA 2343

Human  2340 RGRAFLEHLTDLSIRGTLFVPQNSGLGENETLSGRDIEHHLANVSMFFYNDLVNGTTLQTRLGSK 2404
            ||:|||:|||||||||||||||||||..|::||||||||||.||::.|||||||||.|:|.|||:
  Rat  2344 RGQAFLKHLTDLSIRGTLFVPQNSGLPGNKSLSGRDIEHHLTNVNVSFYNDLVNGTFLRTMLGSQ 2408

Human  2405 LLITASQDPLQPTETRFVDGRAILQWDIFASNGIIHVISRPLKAPPAPVTLTHTGLGAGIFFAII 2469
            ||||:|||.|. .||||||||:||||||.|:|||:|:||.||:|||...|..|:|||.|||.|::
  Rat  2409 LLITSSQDQLH-QETRFVDGRSILQWDIIAANGILHIISEPLRAPPTAATAAHSGLGTGIFCAVV 2472

Human  2470 LVTGAVALAAYSYFRINRRTIGFQHFESEEDINVAALGKQQPENISNPLYESTTSAPPEPSYDPF 2534
            |||||:|||||||||:.:||.|||.|||||||:|.|.|||||:||:|||||::..||||.|.|||
  Rat  2473 LVTGAIALAAYSYFRLKQRTTGFQRFESEEDIDVLAFGKQQPKNIANPLYETSAPAPPESSCDPF 2537

Human  2535 T-------------DSEERQLEGNDPLRTL 2551
            |             |..|:.||.:|||..|
  Rat  2538 TVSLHFTLGPSAFQDPGEQDLEDSDPLGAL 2567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STAB2	NP_060034.9	EGF_3	246..275	CDD:289699	23/28 (82%)
		EGF_3	326..361	CDD:289699	26/34 (76%)
		Fasciclin	382..505	CDD:280607	93/122 (76%)
		Fasciclin	526..654	CDD:280607	101/127 (80%)
		EGF_3	837..865	CDD:289699	21/27 (78%)
		EGF_3	920..951	CDD:289699	29/30 (97%)
		EGF_3	957..993	CDD:289699	30/35 (86%)
		Fasciclin	1009..1129	CDD:280607	97/119 (82%)
		Fasciclin	1148..1265	CDD:280607	102/116 (88%)
		EGF_3	1437..1469	CDD:289699	26/31 (84%)
		EGF_3	1475..1511	CDD:289699	31/35 (89%)
		EGF_3	1517..1553	CDD:289699	32/35 (91%)
		EGF_3	1559..1595	CDD:289699	24/35 (69%)
		Fasciclin	1617..1726	CDD:280607	77/108 (71%)
		Fasciclin	1752..1882	CDD:280607	106/129 (82%)
		EGF_3	2086..2121	CDD:289699	29/34 (85%)
		EGF_3	2127..2164	CDD:289699	33/36 (92%)
		Link_domain_TSG_6_like	2198..2290	CDD:239592	80/91 (88%)
		FAS1	2356..2449	CDD:214719	68/92 (74%)
		Interaction with TMSB4X. /evidence=ECO:0000269\|PubMed:18519035	2504..2514		6/9 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2512..2551		23/51 (45%)
Stab2	XP_038934441.1	EGF_CA	254..283	CDD:419698	23/28 (82%)
		EGF_3	334..369	CDD:403986	26/34 (76%)
		Fasciclin	390..512	CDD:396845	93/122 (76%)
		Fasciclin	533..658	CDD:396845	101/127 (80%)
		EGF_3	840..868	CDD:403986	21/27 (78%)
		EGF_3	881..912	CDD:403986	25/30 (83%)
		EGF_3	923..955	CDD:403986	29/31 (94%)
		EGF_3	961..997	CDD:403986	30/35 (86%)
		Fasciclin	1014..1133	CDD:396845	97/118 (82%)
		Fasciclin	1152..1269	CDD:396845	102/116 (88%)
		EGF_3	1478..1514	CDD:403986	31/35 (89%)
		EGF_3	1520..1556	CDD:403986	32/35 (91%)
		EGF_3	1562..1598	CDD:403986	24/35 (69%)
		Fasciclin	1629..1729	CDD:396845	72/99 (73%)
		Fasciclin	1754..1885	CDD:396845	106/130 (82%)
		EGF_CA	2059..2084	CDD:419698	19/24 (79%)
		EGF_3	2090..2125	CDD:403986	29/34 (85%)
		EGF_3	2131..2168	CDD:403986	33/36 (92%)
		Link_Domain	2202..2294	CDD:413401	80/91 (88%)
		FAS1	2360..2449	CDD:214719	66/89 (74%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83678214
Domainoid	1	1.000	382	1.000	Domainoid score	I11444
eggNOG	1	0.900	-	-		E1_KOG1218
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H23022
Inparanoid	1	1.050	2389	1.000	Inparanoid score	I900
NCBI	1	1.000	-	-
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1964at9347
OrthoFinder	1	1.000	-	-		FOG0005486
OrthoInspector	1	1.000	-	-		oto133337
orthoMCL	1	0.900	-	-		OOG6_105835
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X10174
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	15.200