DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STAB2 and sdz-23

DIOPT Version :9

Sequence 1:	NP_060034.9	Gene:	STAB2 / 55576	HGNCID:	18629	Length:	2551	Species:	Homo sapiens
Sequence 2:	NP_505091.1	Gene:	sdz-23 / 186544	WormBaseID:	WBGene00019066	Length:	267	Species:	Caenorhabditis elegans

Alignment Length:	126	Identity:	29/126 - (23%)
Similarity:	42/126 - (33%)	Gaps:	46/126 - (36%)

- Green bases have known domain annotations that are detailed below.

Human   689 PANSEPTALFTHRCVYSGRFGSLKSGCARYCNATVKIP--------------------------K 727
            |.:|.|..:|.    ||.:..||.:|........|::|                          :
Worm    70 PTSSSPIPIFD----YSIQTLSLITGNIISGKKNVRLPLLVNDPWVHKTISNENGVSVFTSIRFE 130

Human   728 CCKGFYGPDC------------NQCPGGFSNPCSGNGQCADSLGGNGTCICEEGFQGSQCQ 776
            |...||||.|            ::||   ...|..|.||... |....|:|:.|:.|..|:
Worm   131 CLPSFYGPKCQYYCTSGEKCSRDECP---KRKCQNNSQCQFD-GSESKCVCQSGYIGEFCE 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID
STAB2	NP_060034.9	EGF_3	246..275	CDD:289699
		EGF_3	326..361	CDD:289699
		Fasciclin	382..505	CDD:280607
		Fasciclin	526..654	CDD:280607
		EGF_3	837..865	CDD:289699
		EGF_3	920..951	CDD:289699
		EGF_3	957..993	CDD:289699
		Fasciclin	1009..1129	CDD:280607
		Fasciclin	1148..1265	CDD:280607
		EGF_3	1437..1469	CDD:289699
		EGF_3	1475..1511	CDD:289699
		EGF_3	1517..1553	CDD:289699
		EGF_3	1559..1595	CDD:289699
		Fasciclin	1617..1726	CDD:280607
		Fasciclin	1752..1882	CDD:280607
		EGF_3	2086..2121	CDD:289699
		EGF_3	2127..2164	CDD:289699
		Link_domain_TSG_6_like	2198..2290	CDD:239592
		FAS1	2356..2449	CDD:214719
		Interaction with TMSB4X. /evidence=ECO:0000269\|PubMed:18519035	2504..2514
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2512..2551
sdz-23	NP_505091.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1218
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810