Protein Alignment PRIM1 and Prim1

DIOPT Version :10

• Sequence 1: NP_000937.1
• Gene: PRIM1 / 5557
• HGNCID: 9369
• Length: 420
• Species: Homo sapiens
• Sequence 2: NP_523972.2
• Gene: Prim1 / 38942
• FlyBaseID: FBgn0011762
• Length: 438
• Species: Drosophila melanogaster
• Alignment Length: 433
• Identity: 181/433 - (41%)
• Similarity: 263/433 - (60%)
• Gaps: 36/433 - (8%)

Human     1 METFDPTELPELLKLYYRRLFPYSQYYRWLNYGGVIKNYFQHREFSFTLKDDIYIRYQSFNNQSD 65
            :..::|..|.::|.:|||||||:..:||||:||......|.:||.||||:|||||||..|:.|::
  Fly    20 VHAYNPEVLQDMLPVYYRRLFPHLPFYRWLSYGSSEDAIFSNREISFTLQDDIYIRYLCFDTQAE 84

Human    66 LEKEMQKMNPYKIDIGAVYSHRPNQHNTVKLGAFQAQEKELVFDIDMTDYDDVRRCCSSADICPK 130
            ||||:...||.|||||.|...:|..|.::. |.....::||||||||||||:||.|||.|.:|.|
  Fly    85 LEKEICSRNPIKIDIGPVMHSKPKNHRSIP-GGLTPVQRELVFDIDMTDYDEVRTCCSGAGVCLK 148

Human   131 CWTLMTMAIRIIDRALKEDFGFKHRLWVYSGRRGVHCWVCDESVRKLSSAVRSGIVEYLSLV--- 192
            ||..|.:|.|::|.||:|||||:|.:|::|||||:||||||...|.|....|..:.|||:::
  Fly   149 CWKFMVLAARVLDVALREDFGFEHIIWIFSGRRGIHCWVCDYQARHLDGRGRYAVAEYLNIITYA 213

Human   193 --KGGQDVKKKVHLSEKIHPFIRKSINIIKKYFEEYALVNQDILENKESWDKILALVPETIHD-- 253
              .||.  ..:..:.::.|..:::::.|::..|||..|.:|::....:...|:|.:|    ||
  Fly   214 SFAGGN--SPRCSMGDRPHHSLKRALKIVEPMFEEIVLEDQNLFGTPKGVTKLLNMV----HDDA 272

Human   254 ---ELQQSFQK-----SHNSLQRWEHLKKVASRYQNNIKNDKYGPW------LEWEIMLQYCFPR 304
               ||:...||     :|:.|. ||...|    |.|:::......|      :..||.|...:||
  Fly   273 ARGELESYMQKNLEDGAHSRLV-WESFIK----YANSMRTSTTSAWSRKLKNIVAEIQLGLLYPR 332

Human   305 LDINVSKGINHLLKSPFSVHPKTGRISVPIDLQKVDQFDPFTVPTISFICRELDAISTNEEEKEE 369
            |||||::|.|||||:||.:||.||::.||..:..|.:|||.|||||:.:..|::|.  :::.|..
  Fly   333 LDINVTRGFNHLLKAPFCIHPATGKVCVPFSVSAVAKFDPTTVPTITQLLHEINAF--DDKSKSY 395

Human   370 NEAESDVKHRTRDYKKTSLAPYVKVFEHFLENLDKSRKGELLK 412
            .||..| |.|.:|:||||:...|.|||.||..|::|:|...|:
  Fly   396 MEAPED-KSRIKDHKKTSMFKGVVVFEEFLRKLERSQKSASLQ 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PRIM1	NP_000937.1	AE_Prim_S	22..344	CDD:240130	142/342 (42%)
		Zinc knuckle motif. /evidence=ECO:0000269|PubMed:24043831, ECO:0000269|PubMed:25550159, ECO:0000269|PubMed:26975377	121..131		5/9 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	363..382		6/18 (33%)
Prim1	NP_523972.2	AE_Prim_S	41..372	CDD:240130	142/342 (42%)