DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CDC42BPG and gad8

DIOPT Version :9

Sequence 1:	XP_011543457.1	Gene:	CDC42BPG / 55561	HGNCID:	29829	Length:	1569	Species:	Homo sapiens
Sequence 2:	NP_588010.1	Gene:	gad8 / 2539206	PomBaseID:	SPCC24B10.07	Length:	569	Species:	Schizosaccharomyces pombe

Alignment Length:	380	Identity:	142/380 - (37%)
Similarity:	214/380 - (56%)	Gaps:	47/380 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     5 LRALEQLARGEAGGCPGLDG-----------LLDLLLALHHELSSGPLRRERSVAQFL---SWAS 55
            ||:....:|...|....|.|           |.|..:.||.  .||.||     .|.|   :.::
pombe   166 LRSSSSRSRNGMGNDAFLGGIKLSPSFIVNKLTDEWVPLHG--GSGELR-----VQMLYKPNQST 223

Human    56 PFVSKVKELRLQRDDFEILKVIGRGAFGEVTVVRQRDTGQIFAMKMLHKWEMLKRAETACFREER 120
            |         |..|.||:|||:|:|:||:|..||:|||.:|:|:|.:.|..::.|:|......||
pombe   224 P---------LTIDAFELLKVVGKGSFGKVMQVRKRDTSRIYALKTMKKAHIVSRSEVDHTLAER 279

Human   121 DVLVKGDSRWVTTLHYAFQDEEYLYLVMDYYAGGDLLTLLSRFEDRLPPELAQFYLAEMVLAIHS 185
            .||.:.::.::..|.::||....||||:.:..||:|...|.| |.......|:||:||:::|:..
pombe   280 TVLAQVNNPFIVPLKFSFQSPGKLYLVLAFVNGGELFHHLQR-EGCFDTYRAKFYIAELLVALEC 343

Human   186 LHQLGYVHRDVKPDNVLLDVNGHIRLADFGSCLRLNTNGMVDSSVAVGTPDYISPEILQAMEEGK 250
            ||:...::||:||:|:|||..|||.|.|||.| :||......::...|||:|::||:|      .
pombe   344 LHEFNVIYRDLKPENILLDYTGHIALCDFGLC-KLNMAKTDRTNTFCGTPEYLAPELL------L 401

Human   251 GH-YGPQCDWWSLGVCAYELLFGETPFYAESLVETYGKIMNHEDHLQFPPDVPDVPASAQDLIRQ 314
            || |....|||:|||..||::.|..|||.|::.|.|.||:  :|.|:||.::.:   .|:||:..
pombe   402 GHGYTKVVDWWTLGVLLYEMITGLPPFYDENINEMYRKIL--QDPLRFPDNIDE---KAKDLLSG 461

Human   315 LLCR-QEERLGRGGLDDFRNHPFFEGVDWERLASS--TAPYIPELRGPMDTSNFD 366
            ||.| .|:|||.||..:.:|||||:.:||::|.:.  ..|:.|.:...:||||||
pombe   462 LLTRAPEKRLGSGGAQEIKNHPFFDDIDWKKLCAKKIQPPFKPSVESAIDTSNFD 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CDC42BPG	XP_011543457.1	STKc_DMPK_like	69..399	CDD:270748	124/302 (41%)
		S_TKc	71..337	CDD:214567	110/267 (41%)
		TPH	410..802	CDD:290579
		DMPK_coil	744..801	CDD:117396
		C1_1	897..>939	CDD:278556
		PH_MRCK	956..1088	CDD:269949
		CNH	1115..1378	CDD:279162
gad8	NP_588010.1	YPK1_N_like	66..225	CDD:212165	17/74 (23%)
		PTZ00263	214..545	CDD:140289	128/325 (39%)
		STKc_YPK1_like	235..547	CDD:270737	119/295 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910