DRSC/TRiP Functional Genomics Resources

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Protein Alignment PLXNA3 and PlexA

DIOPT Version :10

Sequence 1:NP_059984.3 Gene:PLXNA3 / 55558 HGNCID:9101 Length:1871 Species:Homo sapiens
Sequence 2:NP_524637.2 Gene:PlexA / 43832 FlyBaseID:FBgn0025741 Length:1945 Species:Drosophila melanogaster


Alignment Length:1939 Identity:776/1939 - (40%)
Similarity:1117/1939 - (57%) Gaps:163/1939 - (8%)


- Green bases have known domain annotations that are detailed below.


Human    30 DTTLTHLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARC----YPPPSMRVCAHRL 90
            ||.|.||.|..:||.||||.|||:::|:|:|.......|||..|:..|    .|..::|      
  Fly    72 DTKLNHLLVDTITGRVFVGGVNRLYQLSPDLELSETVKTGPQNDSVECSILDCPLNAVR------ 130

Human    91 APVDNINKLLLIDYAARRLVACGSIWQGICQFLRLDDLFKLGEPHHRKEHYLSGA-QEPDSMAGV 154
            :|.||.||:||||.|..||:||||::||.|....|.::..:       ||.:..| ...|:.:..
  Fly   131 SPTDNYNKVLLIDRATSRLIACGSLFQGTCTVRNLQNVSII-------EHEVPDAVVANDANSST 188

Human   155 IVEQGQGPSK------LFVGTAVDGKSEY---FPTLSSRKLISDEDSADMFSLVYQDEFVSSQIK 210
            :.....||.:      ::||......|.|   .|.::||.|    :...||      :..||.:.
  Fly   189 VAFIAPGPPQHPVTNVMYVGVTYTNNSPYRSEIPAVASRSL----EKTKMF------QIASSAVT 243

Human   211 IPSDTLSLYPAFDIY---YIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEF 272
            ..:.|.....|.:.|   |:|||.|..|.||||.||....    .:..|.:.:|:||:|..||.:
  Fly   244 TGTRTFINSYARETYFVNYVYGFSSERFSYFLTTQLKHSH----HSSPKEYITKLVRICQEDSNY 304

Human   273 YSYVEFPIGC---SWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQ 334
            |||.|.|:.|   :..|.::.|||:..|.||...|||:||:...:||||.:||:|:.|  :|...
  Fly   305 YSYTEIPVECISDAQGGTKFNLVQAGFLGKPSSDLAQSLGISIQDDVLFAVFSKGEGN--TPTNN 367

Human   335 TILCLFTLSNINAHIRRRIQSCYRGEGTLALPWLLNKELPCINTPMQ-INGNFCGLVLNQPLGGL 398
            :.||:::|.:|.....:.|:||:.|.|...|.: ::..:||:.|.:| |..:||||.:|.||||.
  Fly   368 SALCIYSLKSIRRKFMQNIKSCFNGSGMRGLDF-ISPSMPCVLTKLQTIGEDFCGLDVNSPLGGE 431

Human   399 HVIEGLPLLADSTDGMASVAAYTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYETVPVVDGSPIL 463
            ..|..:|:...:|. :.||||.:...::|||:||..|.||||.::....|:.|.:..|..||.|.
  Fly   432 TPITSVPVAMFNTK-LTSVAATSTSGYTVVFVGTSDGFLKKVVIESSSIANEYASFAVDLGSEIN 495

Human   464 RDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCCREGACL-GAS 527
            ||:.|...:.:||::|:.:||::.|..|..|::|..|||:.||:||||.|.::|.....|. .|:
  Fly   496 RDMQFDNQNLYIYVMSKTKVSKVKVFDCSDYKTCGDCLGARDPYCGWCSLENKCSPRSNCQDDAN 560

Human   528 AP-HGFAEELSKCVQV-RVRPNNVSVTSPGVQLTVTLHNVPDLSAGVSCAFEAAAENEAVLLPSG 590
            .| :..:.:..||..: .|.|:.:..|:... |.:.:.::|.|...:.|||  ..|::|:...:.
  Fly   561 DPLYWVSYKTGKCTTITSVVPHQLQRTTART-LELIIDHLPQLKENLICAF--TTEDKALFTNAT 622

Human   591 E----LLCPSPSLQELRALTRG-HGATRTVRLQLLSKETGVRFAGADFVFYNCSVLQSCMSCVGS 650
            :    :.|.:|....|..:.:| |..|..:.::   ...|......||.|::||...||..||.|
  Fly   623 KKRNGVNCTTPRTDMLPQIEQGKHHFTAKLSVR---TRNGPDLVSTDFTFFDCSTHSSCTRCVSS 684

Human   651 PYPCHWCKYRHTCTSRPHE-C--------------SFQEGRVHSPEGCPEILPSGD---LLIPVG 697
            .:||.||...|.||....| |              |::.|    |..||.|..:||   :|:..|
  Fly   685 EFPCDWCVEAHRCTHDTAENCRNDILVTGVSRIGPSYRSG----PGFCPTINATGDGSEVLVAGG 745

Human   698 VMQPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELD 762
            ..:.:.::...:.| ...|..:.|...::||...:.| :....::.|.:..:.|.......| ..
  Fly   746 TSKSIKVKVHIIGQ-FIVQTRFVCQFNIEGRVTSLNA-QLLGDTIYCDSMEFQYTSRSPNLT-AT 807

Human   763 FSVVWDGDFPIDKPPSFRALLYKCWAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHC---PAPK 824
            |:|:|.|..|:|.|.:...::|:|.....|||:||....::|||||.|.:.|::...|   ...|
  Fly   808 FAVIWGGSKPLDNPHNIHVVIYRCREMADSCGICLALSEKYNCGWCSSTNTCEVEEQCNKNKEGK 872

Human   825 TNWMHLSQKGTRCSHPRITQIHPLVGPKEGGTRVTIVGENLGLLSREV--GLRVAGVRCNSIPAE 887
            |:|::.|:   .|.:|.|....|..||.||||.:||.|.|||....::  |:|:||:.|...|..
  Fly   873 TDWLNRSE---ICPNPEIHTFQPKTGPWEGGTNITIRGINLGKNYNDIYSGVRIAGINCMPFPQF 934

Human   888 YISAERIVCEMEESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASGGTR 952
            ||..::|||.::.........|.:.:.:|    |:|.:|::.|.||.|.....:|..||.||||.
  Fly   935 YIDTKQIVCTVDSPGEQMYRNGKIVVQIG----DYRGESKEDYEFVDPKILDFNPKFGPTSGGTE 995

Human   953 LTISGSSLDAGSRVTVTVRDS-ECQFVRRDAKAIVCISPLSTLGPSQAPITLAIDRANISSPGLI 1016
            :.|:|..|:||||:..::.|. .|:.:..|:...:|.:..|. |..:..:.::.|..........
  Fly   996 IHITGKHLNAGSRIQASINDHLPCKILSTDSSQAICRTSASP-GIIEGRLKMSFDNGPREFNDYN 1059

Human  1017 YTYTQDPTVT--------RLEPTWSIINGSTAITVSGTHLLTVQEPRVRAKYRGIETTNTCQVIN 1073
            :.|..||||.        :::....|..|...|:|:||...::|.|.:...|.|....:.|:|.:
  Fly  1060 FKYVLDPTVEHVSSGPSGQIKVPKGIPAGGIRISVTGTQFTSIQNPNIYVVYNGEMYASPCRVQS 1124

Human  1074 DTAMLCKAPGIFLGRPQPRAQGEHPDEFGFLLDHVQTARSLNR---SSFTYYPDPS---FEPLGP 1132
            ||.|.|.:|.:.:......|:.....|:|||:|:|...::|::   :.|..||:|.   ||.   
  Fly  1125 DTEMECASPVVDVDSHVIEAERPILLEYGFLMDNVLRVQNLSKVHNNHFELYPNPEYFIFEE--- 1186

Human  1133 SGVLDVK--PGSHVVLKGKNLIPAAAGSSRLNYTVLIGGQPCSLT-VSDTQLLCDSPSQT----- 1189
                .||  ...::.:.|:||..|...|   :..|.||...|::| :|..||.|..||:.     
  Fly  1187 ----RVKYFKSEYLTINGRNLDRACKES---DVEVKIGNGFCNITSLSRQQLTCRPPSEATATKS 1244

Human  1190 -GRQPVMVLVG-GLEFWLGTLHISAERALT---LPAMMGLAAGGGLLLLAITAVLVAYKRKTQDA 1249
             ....|:|.:| .||:.:|.|...:...:.   ...:..:.|...:|||...|:|||||:|:.::
  Fly  1245 MNGPEVIVRIGTSLEYRIGILSYESSNIILDWGENVIFAVIATIVILLLIFVALLVAYKKKSSES 1309

Human  1250 DRTLKRLQLQMDNLESRVALECKEAFAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAH 1314
            .|.|:.:|.|||.||.|||.|||||||||||::.:||..:....|||||||:||:::|||..|.|
  Fly  1310 SRVLRNMQEQMDILELRVAAECKEAFAELQTEMTDLTGDLTSGGIPFLDYRSYAMKILFPNHEDH 1374

Human  1315 PVLKELDTPP--NVEKALRLFGQLLHSRAFVLTFIHTLEAQSSFSMRDRGTVASLTMVALQSRLD 1377
            .|| :.:.|.  ..||.||:||||:.::.|:|.||.|||:...||||:|..||||.||.|||:|:
  Fly  1375 IVL-QWERPELLRKEKGLRIFGQLIMNKTFLLLFIRTLESNRYFSMRERVNVASLIMVTLQSKLE 1438

Human  1378 YATGLLKQLLADLIEKNLESKNHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCA 1442
            |.|.:||.||.|||||.:|.|:|||||||||||||||||:.||||||:|||||||||||::|:.|
  Fly  1439 YCTDILKTLLGDLIEKCIEGKSHPKLLLRRTESVAEKMLSAWFTFLLYKFLKECAGEPLYMLFRA 1503

Human  1443 IKQQMEKGPIDAITGEARYSLSEDKLIRQQIDYKTLTLHC-------------VCPENEGSAQVP 1494
            :|.|::|||:||.|.||||||||:|||||.||::.:.::.             :.|.:  :..|.
  Fly  1504 VKGQVDKGPVDACTHEARYSLSEEKLIRQSIDFRPMNVYASIIQQPIFCNNLDMLPSH--TENVS 1566

Human  1495 VKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAEDMDLEWRQGRMTRIILQDEDVTTKIECDWKRL 1559
            ||||:||:|.|.|:|.|:|:|:.||.||||:.:|:|||||.|...|:||.|||||:|.|.:||:|
  Fly  1567 VKVLDCDTIGQVKEKCLETIYRNIPSSQRPRKDDLDLEWRTGATGRVILYDEDVTSKTESEWKKL 1631

Human  1560 NSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTRSLSRYESL---LRTASSPDSLRSRAPMITPD 1621
            |:|.||.|.||:.::|||||.|.||.:..........:||:|   ..|:|||...|:.:|:....
  Fly  1632 NTLQHYNVPDGAGLSLVPKQSSIYNFSILSDKNEKSHKYETLNISKYTSSSPTFSRAGSPLNNDM 1696

Human  1622 QETGTKLWHLVKNHDHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSAL 1686
            .|.|.:.|||||:||....:||:|.:|:||||||||||||||||||||||||||:||||||||||
  Fly  1697 HENGLRYWHLVKHHDSDMQKEGERVNKLVSEIYLTRLLATKGTLQKFVDDLFETIFSTAHRGSAL 1761

Human  1687 PLAIKYMFDFLDEQADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVV 1751
            ||||||||||||:||....|:||:|.||||||.||||||||:||||.|||||||::|.|:|||||
  Fly  1762 PLAIKYMFDFLDDQAQLHGITDPEVVHTWKSNSLPLRFWVNLIKNPNFVFDIHKSNIVDSCLSVV 1826

Human  1752 AQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRL 1816
            |||||||||||:|||||||||:|||||||||.|:.||:||||||..|:.||||||:|.|.|:|||
  Fly  1827 AQTFMDSCSTSDHRLGKDSPSSKLLYAKDIPEYRKWVDRYYRDIRDMSPISDQDMNAMLAEESRL 1891

Human  1817 HASDFSVLSALNELYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSD 1870
            |.::|:...||:|||.|..||.:::...|:.|...:|.:|..||||:.:::||:
  Fly  1892 HTTEFNTNCALHELYTYAVKYNEQLTVTLEEDEFSQKQRLAFKLEQVHNIMSSE 1945

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PLXNA3NP_059984.3 Sema_plexin_A3 21..489 CDD:200534 167/479 (35%)
PSI 490..>527 CDD:396154 15/37 (41%)
TIG_plexin 546..636 CDD:465588 19/94 (20%)
PSI 637..684 CDD:396154 19/61 (31%)
TIG_2 690..784 CDD:465619 20/96 (21%)
PSI 788..837 CDD:396154 17/51 (33%)
IPT_plexin_repeat1 840..934 CDD:238585 33/95 (35%)
IPT_plexin_repeat2 935..1021 CDD:238584 23/86 (27%)
IPT_plexin_repeat3 1023..1123 CDD:238586 29/110 (26%)
IPT_PCSR 1125..1208 CDD:238337 27/95 (28%)
Plexin_cytopl 1293..1836 CDD:462434 342/560 (61%)
PlexANP_524637.2 Sema_plexin_like 75..520 CDD:200497 165/475 (35%)
PSI 522..574 CDD:396154 18/51 (35%)
TIG_plexin 580..670 CDD:465588 19/95 (20%)
PSI 671..>702 CDD:396154 14/30 (47%)
TIG_2 738..829 CDD:465619 18/93 (19%)
PSI 830..883 CDD:396154 18/55 (33%)
IPT_plexin_repeat1 885..977 CDD:238585 33/95 (35%)
IPT_plexin_repeat2 978..1063 CDD:238584 22/85 (26%)
IPT 1078..1177 CDD:472823 26/98 (27%)
TIG <1196..>1246 CDD:460355 16/52 (31%)
Plexin_cytopl 1353..1911 CDD:462434 342/560 (61%)

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