Protein Alignment PLXNA3 and PlexB

DIOPT Version :10

• Sequence 1: NP_059984.3
• Gene: PLXNA3 / 55558
• HGNCID: 9101
• Length: 1871
• Species: Homo sapiens
• Sequence 2: NP_524616.2
• Gene: PlexB / 43766
• FlyBaseID: FBgn0025740
• Length: 2051
• Species: Drosophila melanogaster
• Alignment Length: 2056
• Identity: 682/2056 - (33%)
• Similarity: 1038/2056 - (50%)
• Gaps: 316/2056 - (15%)

Human    34 THLAVHRVTGEVFVGAVNRVFKLAPNLTELRAHVTGPVEDNARCYP---PPSMRVCAHRLAPVDN 95
            ||::...:...:|.||.|::.||..||..|...||||:.|:.:|:.   |..:..     :.|:|
  Fly    88 THMSFDFMHNVLFAGATNKILKLNENLRVLAEAVTGPLHDSPQCHAGGCPEDIET-----SLVNN 147

Human    96 INKLLLIDYAARR-LVACGSIWQGICQFLRL------DDLFKLGEPHHRKEHYLSGAQEPDSMAG 153
            .||:|::.||... |:|||||.||.|:...|      ...|.:.         |:...|..|...
  Fly   148 FNKILVVSYAHDGILIACGSIRQGACEIYSLPRFPATPQFFAVP---------LAANDENASTYA 203

Human   154 VIVEQGQGPSK--------LFVGTAVDGKSEY---FPTLSSRKLISDEDSADMFSLVYQDEFVSS 207
            .:     ||::        |:|||......:|   .|.:|||:|  |:.:...||:  |...::.
  Fly   204 FV-----GPARYAWKEEDILYVGTTFTNVGDYRHDVPAISSRRL--DDLNYAEFSI--QQSIINI 259

Human   208 QIKIPSDTLSLYPAFDIYYIYGFVSASFVYFLTLQLDTQQTLLDTAGEKFFTSKIVRMCAGDSEF 272
            .:|....       |.:.|||||.|:.:.||:.:|  .:..|.|.||   :.:::.|:|..|..:
  Fly   260 DVKYRDH-------FLVDYIYGFNSSEYAYFIIVQ--KKSHLADEAG---YVTRLARICITDPNY 312

Human   273 YSYVEFPIGC--SWRGVEYRLVQSAHLAKPGLLLAQALGVPADEDVLFTIFSQGQKNRASPPRQT 335
            .||.|..:.|  :...|:|.:|:.|.:......|||.:|:..|:.||.|:||..::....|..::
  Fly   313 DSYTEITVQCTATENNVDYNIVRDAKVTPASHKLAQKMGIKKDDHVLVTVFSPSREISNQPESKS 377

Human   336 ILCLFTLSNINAHIRRRIQSCYRG----------EGTLALPWLLNKELPCINTPMQINGNFCGLV 390
            .:|::::.:|.......|..|:.|          .||:.     :...|.:.:...|. |||.:.
  Fly   378 AMCIYSIKDIEDMFIENIHLCFNGTTKDRNLGYISGTIN-----DGRCPIVGSLGNIY-NFCSVG 436

Human   391 LNQPLGGLHVIEGLPLLADSTDGMASVAA--YTYRQHSVVFIGTRSGSLKKVRVDGFQDAHLYET 453
            |.  :.|:..|....|.......:.||.|  .|.:|||:.|:||..|.:|||.:.| |....||.
  Fly   437 LK--ISGVSPITAHALFHFDNVSVTSVTATSTTDQQHSLAFLGTNMGVIKKVLLSG-QSPGEYEE 498

Human   454 VPVVDGSPILRDLLFSPDHRHIYLLSEKQVSQLPVETCEQYQSCAACLGSGDPHCGWCVLRHRCC 518
            :.|..|:.||.:.:.||....:|:||::::::|.:|.|..|.:|:|||.|.||.||||.|..||.
  Fly   499 IVVDAGNRILPNTMMSPKKDFLYVLSQRKITKLRIEHCSVYTNCSACLESRDPFCGWCSLEKRCT 563

Human   519 REGAC-----------LGASAPHGFAEELSKCVQVR-VRPNNVSVTSPGVQLTVTLHNVPD-LSA 570
            ....|           ||:.         .:|::.. :.|..:.::... .|.:.:..:|: .:|
  Fly   564 VRSTCQRDTSASRWLSLGSG---------QQCIEFESIIPEKIPISELS-HLHLIIRTLPEPFNA 618

Human   571 GVSCAFEAAAENEAVLLPSGELLCPSPSLQELRALTRGHGATRTVRLQLLSKETGVRFAGADFVF 635
            ...|.|..:...:|.:|.:| |.|.:|.|.| |.|...:.....|.|.:.|.||...|...:|.|
  Fly   619 KYRCVFGNSTPIDAEILENG-LGCATPPLDE-RPLIPTNTDHILVPLSVRSSETNKDFVSRNFAF 681

Human   636 YNCSVLQSCMSCVGSPYPCHWCKYRHTCTSRPHECSFQEGRVHSPEGCPEILPS-GDLLIPVGVM 699
            ::||...:|..|:.|.:.|:||.:.:.|..:..:|...|..|.:...||.:..: .::|:||.|.
  Fly   682 FDCSHHGNCQECLQSSWGCNWCIFDNKCVHKSLQCRNIENAVSTVGHCPHLKKNRPEILLPVRVP 746

Human   700 QPLTLRAKNLPQPQSGQKNYECVVRVQGRQQRVPAVRFNSSSVQCQNASYSYEGDEHGDTELDFS 764
            ..:.|..:|||:|:|....:.|.:.::..|..:||...::..|.|:...|.||.:.| :.:....
  Fly   747 IEIRLEIENLPKPKSAHAGFLCTIHIEAAQMLLPAHVESNKIVVCEKTPYFYEINTH-EYQAKVV 810

Human   765 VVWDGDFPIDKPPSFRALLYKC-----WAQRPSCGLCLKADPRFNCGWCISEHRCQLRTHCPAPK 824
            |.|:....:|   :....||||     ..:.|.|.||:..||::.|.||  .:.|.....|.|.|
  Fly   811 VTWNFQHYVD---TAIVTLYKCDVLGSHREHPDCSLCVTRDPKYKCAWC--SNSCVYNETCIADK 870

Human   825 TNWMHLSQKG--TRCSHPRITQIHPLVGPKEGGTRVTIVGENLGLLSREVGLRVAGVRCNSIPAE 887
            .:....|:..  ..|..|||..|.||.||.||||.:||.|.|||:  ||..:| ..:...|:|.|
  Fly   871 NSISSGSKSAIENECPLPRIDIIKPLSGPVEGGTLITIEGSNLGI--REEDVR-GKIFIGSVPCE 932

Human   888 ---YISAERIVCEMEESLVPSPPPGPVELCVGDCSADFRTQSEQVYSFVTPTFDQVSPSRGPASG 949
               |..:.:|.|....||.....|..|....|      .|:|...:.|.......:.|:.||.||
  Fly   933 LENYQISVKIECRTGASLYEMSAPIKVANDAG------FTESSVQFHFKNVLLTGLYPTIGPRSG 991

Human   950 GTRLTISGSSLDAGSRVTVTVRDSECQF--VRRDAKAIVCISPLSTLGPSQAPITLAIDRAN--- 1009
            ||:|::.|..|:.||.:...:.:.||..  .:..:..:.|.:..:|.......:.|.||.||
  Fly   992 GTQLSLIGKFLNIGSTMRAFLDEYECHIDVTQASSSQVSCTTSEATQPEPIRSLHLVIDGANRTL 1056

Human  1010 ---ISSPGL------------------------IYTYTQDPTVTRLEPTWSIINGSTAITVSGTH 1047
               ||:|.:                        |:.|||||.:.:::|..|..:|...:||.|.:
  Fly  1057 ECQISTPSITNTNPTRSNFGSYQLRSLPRQPCSIFNYTQDPRIMQIKPLRSFKSGGRVLTVHGIY 1121

Human  1048 LLTVQEPRVRAKYRGIETTNT-CQVINDTAMLCKAPGI------------------------FLG 1087
            |.::|:|.:...|.......| |.|||...|.|.:|.:                        |
  Fly  1122 LNSIQKPELEVFYDNERVNKTSCVVINSNQMECPSPPVNYKFETFKKTNRKMDTELHLQNSSF-- 1184

Human  1088 RPQPRAQGEHP-----DEFG---------------------------------------FLLDHV 1108
            :.:.|.:.|:.     .:||                                       |::|:|
  Fly  1185 QTETRYKNEYDRKKRRADFGDTFRLYTNAGSSANYFVNNNMDVTTFVKVHETQLNLQLSFVMDNV 1249

Human  1109 QTARSLN------RSSFTYYPDPSFEPLGPSGVLDVKPGSHVVLKGKNLIPAAAGSSRLNYTVLI 1167
            |..|:||      ||:..|..||.:.|....||...| |..:|::|: |:..||....:|.|  |
  Fly  1250 QLVRNLNKYFHDIRSTIVYLADPKYLPFPNDGVKLYK-GDSLVIEGE-LLNLAADEYDVNVT--I 1310

Human  1168 GGQPCSLT-VSDTQLLCDSPSQTGRQP----------------VMVLVG-GLEFWLGTLHISAER 1214
            |...|::| ::..||||..|.|   ||                |:|.|| .|.|.:|.|...
  Fly  1311 GTSQCNITSLALNQLLCIPPEQ---QPLPTDENGVDQSTDLPLVVVKVGRNLRFVIGYLKYD--- 1369

Human  1215 ALTLPAMMGLAAGGGLLLLAI-----TAVLVAYKRKTQDADRTLKRLQLQMDNLESRVALECKEA 1274
             |..|.:...|...|:|.:|:     ..||:.::||:..|:|..||:|:||..|||.|..|||:|
  Fly  1370 -LNKPYVFSHALLVGILTVALLVVVFVIVLIIFRRKSTQAEREYKRIQIQMITLESNVRSECKQA 1433

Human  1275 FAELQTDINELTNHMDEVQIPFLDYRTYAVRVLFPGIEAHPVL-----KELDTPPNVEKALRLFG 1334
            |||||||:.:||..::...||.||:..|.::|.|||:..||:|     :|.....|.:.|:..|.
  Fly  1434 FAELQTDMTDLTADLESTGIPTLDHVNYIMKVFFPGVSDHPILNSPKFREGSPQTNYDAAMVQFE 1498

Human  1335 QLLHSRAFVLTFIHTLEAQ-SSFSMRDRGTVASLTMVALQSRLDYATGLLKQLLADLIEKNLESK 1398
            ||:.::.|:|.||.||||| ||||:|||..||||.||.|.::::|||.:||.||..||:|:|.||
  Fly  1499 QLIGNKYFLLMFIETLEAQRSSFSIRDRVNVASLIMVVLMNKMEYATEILKSLLLRLIDKSLASK 1563

Human  1399 NHPKLLLRRTESVAEKMLTNWFTFLLHKFLKECAGEPLFLLYCAIKQQMEKGPIDAITGEARYSL 1463
             ||:|:|||||||.||||||:....::.:|||.||..||||:.|||.|:|||.:||||.:|||||
  Fly  1564 -HPQLMLRRTESVVEKMLTNYLAICMYDYLKEYAGSNLFLLFKAIKHQIEKGLVDAITNDARYSL 1627

Human  1464 SEDKLIRQQIDYKTLTLHCVCPENEGSAQVPVKVLNCDSITQAKDKLLDTVYKGIPYSQRPKAED 1528
            ||::|:.:|:.:..:.||.:  :::...:|..:|.:.|:|:|.|.|:||.::|..|:|.||...:
  Fly  1628 SEERLLHEQVTHSVVILHIL--QDDLDEKVQCRVNDWDTISQVKLKILDAIFKNTPFSMRPSVNE 1690

Human  1529 MDLEWRQGRMTRIILQDEDVTTKIECDWKRLNSLAHYQVTDGSLVALVPKQVSAYNMANSFTFTR 1593
            :|||||.||...:.|||||:|||....|||||:||||.|.:.::::|:.:|...|::  .::..:
  Fly  1691 VDLEWRHGRGGHLTLQDEDLTTKTVNGWKRLNTLAHYGVKESAVMSLIARQNDNYHI--PYSKNQ 1753

Human  1594 SLSRYESLLRTASSPDSLRSRAPMITPDQETG---TKLWHLVK----NH---------------- 1635
            :.:.|.:.....:|...:     :|..|.|:|   .:::||||    :|
  Fly  1754 NSAPYHNFYFINNSQSHI-----IINNDIESGLQQPRVYHLVKPNIPDHYMNIKNSVLSGGSPAF 1813

Human  1636 -DHADHREGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETVFSTAHRGSALPLAIKYMFDFLDE 1699
             .|..:...||.:|.:.|:|||||||||||:||||||.|..:.:.   ...||.|:|::||.|||
  Fly  1814 QSHVVNNCNDRVNKTIPEVYLTRLLATKGTIQKFVDDFFSIILTV---NEELPPAVKWLFDLLDE 1875

Human  1700 QADQRQISDPDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKNSITDACLSVVAQTFMDSCSTSEH 1764
            .|.:..|:|.|:.|.|||||||||||||.||||.|:||::|....|:||||:||||||:||||||
  Fly  1876 AARRHDIADTDIVHAWKSNCLPLRFWVNFIKNPDFIFDVNKTYSVDSCLSVIAQTFMDACSTSEH 1940

Human  1765 RLGKDSPSNKLLYAKDIPNYKSWVERYYRDIAKMASISDQDMDAYLVEQSRLHASDFSVLSALNE 1829
            ||||||||||||:|||||||:..|:.:|||::::..||||:|...:.:.|.....:|..:|||.|
  Fly  1941 RLGKDSPSNKLLFAKDIPNYRIMVKEFYRDVSRLPQISDQEMSTAMQQLSVRQNEEFDTISALKE 2005

Human  1830 LYFYVTKYRQEILTALDRDASCRKHKLRQKLEQIISLVSSD 1870
            ||.|:|||:.:|:.:|:.|.:|||..|.:||..:.:.:..|
  Fly  2006 LYIYITKYKDQIMESLETDINCRKMHLSRKLGNVAATLDGD 2046

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PLXNA3	NP_059984.3	Sema_plexin_A3	21..489	CDD:200534	136/489 (28%)
		PSI	490..>527	CDD:396154	19/47 (40%)
		TIG_plexin	546..636	CDD:465588	23/90 (26%)
		PSI	637..684	CDD:396154	12/46 (26%)
		TIG_2	690..784	CDD:465619	23/93 (25%)
		PSI	788..837	CDD:396154	14/50 (28%)
		IPT_plexin_repeat1	840..934	CDD:238585	35/96 (36%)
		IPT_plexin_repeat2	935..1021	CDD:238584	26/117 (22%)
		IPT_plexin_repeat3	1023..1123	CDD:238586	34/174 (20%)
		IPT_PCSR	1125..1208	CDD:238337	32/100 (32%)
		Plexin_cytopl	1293..1836	CDD:462434	266/572 (47%)
PlexB	NP_524616.2	Sema_plexin_like	86..534	CDD:200497	136/489 (28%)
		PSI	535..586	CDD:396154	19/59 (32%)
		TIG_plexin	594..682	CDD:465588	23/90 (26%)
		PSI	683..730	CDD:214655	12/46 (26%)
		TIG_2	738..827	CDD:465619	23/92 (25%)
		PSI	836..877	CDD:214655	13/42 (31%)
		IPT_plexin_repeat1	888..976	CDD:238585	35/96 (36%)
		IPT_plexin_repeat2	977..1095	CDD:238584	26/117 (22%)
		IPT_plexin_repeat3	1097..1211	CDD:238586	24/115 (21%)
		TIG	1277..>1334	CDD:460355	21/63 (33%)
		Plexin_cytopl	1452..2012	CDD:462434	266/572 (47%)