DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment myh10 and zip

DIOPT Version :9

Sequence 1:	XP_009300420.1	Gene:	myh10 / 555454	ZFINID:	ZDB-GENE-030616-162	Length:	2014	Species:	Danio rerio
Sequence 2:	NP_523860.2	Gene:	zip / 38001	FlyBaseID:	FBgn0265434	Length:	2056	Species:	Drosophila melanogaster

Alignment Length:	2033	Identity:	1230/2033 - (60%)
Similarity:	1566/2033 - (77%)	Gaps:	62/2033 - (3%)

- Green bases have known domain annotations that are detailed below.

Zfish     3 EMAQRSGQEDPE-RYLFVDRAVVYNPTTQADWTAKKLVWVPSERHGFEAASIREERGEEVLVELA 66
            :|::...:.||| :||.|:|....:|.|||:||.|:|||||.|..||.||||:.|.|:||.||||
  Fly    45 KMSEEVDRNDPELKYLSVERNQFNDPATQAEWTQKRLVWVPHENQGFVAASIKREHGDEVEVELA 109

Zfish    67 ENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGLFCVVINPY 131
            |.||:.|:.:|||||||||||.|||||||||||||||||||:|||||||||||||||||||:|||
  Fly   110 ETGKRVMILRDDIQKMNPPKFDKVEDMAELTCLNEASVLHNIKDRYYSGLIYTYSGLFCVVVNPY 174

Zfish   132 KNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKTENTKKVIQ 196
            |.||||:|.|:|.|:|.||||:|||::||::||||.||.||||||||||||||||||||||||||
  Fly   175 KKLPIYTEKIMERYKGIKRHEVPPHVFAITDSAYRNMLGDREDQSILCTGESGAGKTENTKKVIQ 239

Zfish   197 YLAHVASSH---KGRKDH-----NIPPESPKAVKLQ-------------NGILFY--------GE 232
            :||:||:|.   .|...|     |....:.|.:|::             ||:...        ||
  Fly   240 FLAYVAASKPKGSGAVPHPAVLINFSVNTNKYIKVKIMAQNQNQTIEVVNGLKMVEVNSNCQEGE 304

Zfish   233 LERQLLQANPILESFGNAKTVKNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDE 297
            ||:||||||||||:||||||||||||||||||||||||.:|:|.|||||||||||||||||||||
  Fly   305 LEQQLLQANPILEAFGNAKTVKNDNSSRFGKFIRINFDASGFISGANIETYLLEKSRAIRQAKDE 369

Zfish   298 RTFHVFYQLLAGAGEHLRSDLLLEGFNSYRFLSNGNIPIPGQQDKDNFQETMEAMHIMSFNHEEI 362
            ||||:||||||||....|...:|:...||.|||||::|:||..|...||.|:::|:||....|:.
  Fly   370 RTFHIFYQLLAGATPEQREKFILDDVKSYAFLSNGSLPVPGVDDYAEFQATVKSMNIMGMTSEDF 434

Zfish   363 LSMLKVVSAVLQFGNIVFKKERNTDQASMPENTAAQKLCHLLGMNVMEFTRAILSPRIKVGRDYV 427
            .|:.::|||||.||::.|::|||.|||::|:||.|||:.||||::|.:.|||.|:||||||||:|
  Fly   435 NSIFRIVSAVLLFGSMKFRQERNNDQATLPDNTVAQKIAHLLGLSVTDMTRAFLTPRIKVGRDFV 499

Zfish   428 QKAQTKEQADFAVEALAKATYERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFQLNSFEQ 492
            .|||||||.:|||||:|||.|||:|:|||:|||::||||||||||||||||:||||||:||||||
  Fly   500 TKAQTKEQVEFAVEAIAKACYERMFKWLVNRINRSLDRTKRQGASFIGILDMAGFEIFELNSFEQ 564

Zfish   493 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWSFIDFGLDLQPCIDLIERPANPPGVLALLDEE 557
            |||||||||||||||||||||||||||||||||.||||||||||.||||::|.   |::||||||
  Fly   565 LCINYTNEKLQQLFNHTMFILEQEEYQREGIEWKFIDFGLDLQPTIDLIDKPG---GIMALLDEE 626

Zfish   558 CWFPKATDKTFVDKLVQEQGTHGKFQKPRQLKDKADFCIIHYAGRVDYKADEWLMKNMDPLNDNV 622
            ||||||||||||||||.....|.||.| ...:..|||.|:||||||||.|.:||||||||||:|:
  Fly   627 CWFPKATDKTFVDKLVSAHSMHPKFMK-TDFRGVADFAIVHYAGRVDYSAAKWLMKNMDPLNENI 690

Zfish   623 ATLLHQSTDKFVAELWKDEIQNFQRASFYDVSSLHESPGEVDRIVGLDQVAGMNETAFGAAYKTK 687
            .:||..|.|.||..:|||.                       .|||:.|.| :.:|.|||  :|:
  Fly   691 VSLLQGSQDPFVVNIWKDA-----------------------EIVGMAQQA-LTDTQFGA--RTR 729

Zfish   688 KGMFRTVGQLYKESLTKLMATLRNTNPNFVRCIIPNHEKRAGKLEPHLVLDQLRCNGVLEGIRIC 752
            |||||||..||||.|.|||.|||||||||||||||||||||||::..||||||||||||||||||
  Fly   730 KGMFRTVSHLYKEQLAKLMDTLRNTNPNFVRCIIPNHEKRAGKIDAPLVLDQLRCNGVLEGIRIC 794

Zfish   753 RQGFPNRIVFQEFRQRYEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRTGVLA 817
            ||||||||.|||||||||:||||.|||||||||:|||:||:|||||.||||:||||||||.||||
  Fly   795 RQGFPNRIPFQEFRQRYELLTPNVIPKGFMDGKKACEKMIQALELDSNLYRVGQSKIFFRAGVLA 859

Zfish   818 HLEEERDLKITDIIIYFQSVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRLFTKV 882
            |||||||.||:|:|:.||:.|||:|||:.:.|:.|||:|::::|||||||||||:||||||:|||
  Fly   860 HLEEERDFKISDLIVNFQAFCRGFLARRNYQKRLQQLNAIRIIQRNCAAYLKLRNWQWWRLYTKV 924

Zfish   883 KPLLQVTRQEEEMQAKDEELIKVKERQVKVENELVEMERKHQQLLEEKNILAEQLQAETELFAEA 947
            ||||:||:|||::..|::||.:|:|:...:.....|.|||:||.|.||..||||||||.||.|||
  Fly   925 KPLLEVTKQEEKLVQKEDELKQVREKLDTLAKNTQEYERKYQQALVEKTTLAEQLQAEIELCAEA 989

Zfish   948 EEMRARLVAKKQELEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQDLEEQLDEEEAARQKLQL 1012
            ||.|:||:|:|||||:::.:||:|:||||||..:|..||||::.:||||||||:|||||||||||
  Fly   990 EESRSRLMARKQELEDMMQELETRIEEEEERVLALGGEKKKLELNIQDLEEQLEEEEAARQKLQL 1054

Zfish  1013 EKVTAEAKIKKMEEDILLLEDQNSKFLKEKKLLEDRVGEMTSQLAEEEEKAKNLGKVKNKQEMMM 1077
            |||..:|||||.|||:.|.:|||.|.||||||||:|..:::..|||||||||:|.|:|.|.|..:
  Fly  1055 EKVQLDAKIKKYEEDLALTDDQNQKLLKEKKLLEERANDLSQTLAEEEEKAKHLAKLKAKHEATI 1119

Zfish  1078 VDLEERLKKEEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDE 1142
            .:|||||.|:::.|||.:::|||::.|..||::|:.|.:.|:||::.||||:||||...|.|.||
  Fly  1120 SELEERLHKDQQQRQESDRSKRKIETEVADLKEQLNERRVQVDEMQAQLAKREEELTQTLLRIDE 1184

Zfish  1143 EVAQKNNALKQLRELQAQLAELQEDLESEKAARNKAEKLKRDLSEELEALKTELEDTLDTTAAQQ 1207
            |.|.|..|.|..|||::||||:|||||:|||||.||||::|||||||||||.||.|:||||||||
  Fly  1185 ESATKATAQKAQRELESQLAEIQEDLEAEKAARAKAEKVRRDLSEELEALKNELLDSLDTTAAQQ 1249

Zfish  1208 ELRSKREQEVAELKKAIDDETRNHESQIQEMRQRHGTALEEISEQLEQAKRVKGNLEKNKQTLES 1272
            |||||||||:|.|||::::||.|||..:.:||.:|...|..|::|||..::.|..|||.|.|||:
  Fly  1250 ELRSKREQELATLKKSLEEETVNHEGVLADMRHKHSQELNSINDQLENLRKAKTVLEKAKGTLEA 1314

Zfish  1273 DNKELTNEVKSLQQAKSESEHKRKKLEAQLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLL 1337
            :|.:|..|::|:..::.|::.:||:.|:|:.|:..:.:|.|:.:.||.::..|:|.|.:|::..|
  Fly  1315 ENADLATELRSVNSSRQENDRRRKQAESQIAELQVKLAEIERARSELQEKCTKLQQEAENITNQL 1379

Zfish  1338 EDAEKKGIKLTKDVSSLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQEEEEESRKN 1402
            |:||.|.....|..|::||||.:.|:||:|||||||.|||::||:|.||..|.||.||::|:::|
  Fly  1380 EEAELKASAAVKSASNMESQLTEAQQLLEEETRQKLGLSSKLRQIESEKEALQEQLEEDDEAKRN 1444

Zfish  1403 LEKQLATLQAQLVETKKKLEDDVGALEGLEEVKRKLQKDMEVTSQKLEEKAIAFDKLEKTKNRLQ 1467
            .|::||.:..|:.|.|||.|:|....:.|||.|::|.||:|...::::|.....|:|:|:|.::|
  Fly  1445 YERKLAEVTTQMQEIKKKAEEDADLAKELEEGKKRLNKDIEALERQVKELIAQNDRLDKSKKKIQ 1509

Zfish  1468 QELDDLMVDLDHQRQIVSNLEKKQKKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSMARA 1532
            .||:|..::|:.||..|..||||||.||::|||||.||.:.|:|||.||.|||||:||.||::|.
  Fly  1510 SELEDATIELEAQRTKVLELEKKQKNFDKILAEEKAISEQIAQERDTAEREAREKETKVLSVSRE 1574

Zfish  1533 LDEALEAKEEFERLNKQLRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVEEMRTQLEELEDELQ 1597
            ||||.:..|:.|...|.|:.|::||.:::....||||||||:||.||.|:.|::.|.|||||:||
  Fly  1575 LDEAFDKIEDLENKRKTLQNELDDLANTQGTADKNVHELEKAKRALESQLAELKAQNEELEDDLQ 1639

Zfish  1598 ATEDAKLRLEVNMQAMKAQFDRDLQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKK 1662
            .||||||||||||||:::||:|||.|::|..|||:|.||||:|::|.||::|||||..|||:|||
  Fly  1640 LTEDAKLRLEVNMQALRSQFERDLLAKEEGAEEKRRGLVKQLRDLETELDEERKQRTAAVASKKK 1704

Zfish  1663 LEMDLKDVEAQIEAANKARDEAIKQLRKLQAQMKDYQRELEEARTSRDEIFTQSKENEKKLKSLE 1727
            ||.|||::|..:|..||.:::|:|..:|||||:||..|:.|||:.:::|:...|||.|:|:|:||
  Fly  1705 LEGDLKEIETTMEMHNKVKEDALKHAKKLQAQVKDALRDAEEAKAAKEELQALSKEAERKVKALE 1769

Zfish  1728 AEILQLQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRLEARIAQLEEELEEEQSN 1792
            ||:|||.|||||||||||.||.||||||:||:|:|:..:.::|||||||||||.|||||||||||
  Fly  1770 AEVLQLTEDLASSERARRAAETERDELAEEIANNANKGSLMIDEKRRLEARIATLEEELEEEQSN 1834

Zfish  1793 MELLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKSKLQELEGSVKSKFKASI 1857
            .|:|.||.||..:|::.|.||||.|:|.:||:||.|..||||||:||:||.|:|.:.::|.||:|
  Fly  1835 SEVLLDRSRKAQLQIEQLTTELANEKSNSQKNENGRALLERQNKELKAKLAEIETAQRTKVKATI 1899

Zfish  1858 AALEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVEDERRHADQYKEQMEKANSRMKQ 1922
            |.|||||..||||||.|.|||....|..|:.:||:||:.|.:||||||.||:||||:|.|||:|.
  Fly  1900 ATLEAKIANLEEQLENEGKERLLQQKANRKMDKKIKELTMNIEDERRHVDQHKEQMDKLNSRIKL 1964

Zfish  1923 LKRQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTLKNRLRRGGPVSFSSSR-SGRRQ 1986
            |||.|:|.|||..:....:||.|||.:|..|:.|.::||:|:||.:|||.|.:..|||| :|...
  Fly  1965 LKRNLDETEEELQKEKTQKRKYQRECEDMIESQEAMNREINSLKTKLRRTGGIGLSSSRLTGTPS 2029

Zfish  1987 LQMEGDFSDDDADSKASD 2004
            .:..|.....| ||...|
  Fly  2030 SKRAGGGGGGD-DSSVQD 2046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
myh10	XP_009300420.1	Myosin_N	37..75	CDD:280832	24/37 (65%)
		Myosin_head	90..812	CDD:278492	512/750 (68%)
		MYSc_Myh10	102..812	CDD:276952	500/738 (68%)
		Myosin_tail_1	889..1969	CDD:279860	598/1079 (55%)
		DUF342	<1085..1170	CDD:302792	43/84 (51%)
		RILP-like	<1528..1637	CDD:304877	61/108 (56%)
		GBP_C	<1641..1734	CDD:303769	49/92 (53%)
		coiled coil	1705..1714	CDD:293879	2/8 (25%)
		coiled coil	1723..1734	CDD:293879	7/10 (70%)
zip	NP_523860.2	Myosin_N	80..117	CDD:280832	23/36 (64%)
		Myosin_head	133..854	CDD:278492	512/750 (68%)
		MYSc_Myh2_insects_mollusks	145..854	CDD:276876	500/738 (68%)
		Myosin_tail_1	931..2011	CDD:279860	598/1079 (55%)
		Prefoldin	1431..1515	CDD:298833	33/83 (40%)
		FAM76	<1847..1926	CDD:292665	45/78 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	1148	1.000	Domainoid score	I16
eggNOG	1	0.900	-	-		E2759_KOG0161
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55941
Inparanoid	1	1.050	2314	1.000	Inparanoid score	I32
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D40305at33208
OrthoFinder	1	1.000	-	-		FOG0000014
OrthoInspector	1	1.000	-	-		otm24342
orthoMCL	1	0.900	-	-		OOG6_100110
Panther	1	1.100	-	-	O	PTHR45615
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R786
SonicParanoid	1	1.000	-	-		X58
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.860