DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment myh10 and Mhc

DIOPT Version :9

Sequence 1:XP_009300420.1 Gene:myh10 / 555454 ZFINID:ZDB-GENE-030616-162 Length:2014 Species:Danio rerio
Sequence 2:NP_001162991.1 Gene:Mhc / 35007 FlyBaseID:FBgn0264695 Length:1962 Species:Drosophila melanogaster


Alignment Length:1998 Identity:779/1998 - (38%)
Similarity:1198/1998 - (59%) Gaps:98/1998 - (4%)


- Green bases have known domain annotations that are detailed below.


Zfish     1 MPEMAQRSGQEDPERYLFV-------DRAVVYNPTTQADWTAKKLVWVPSERHGFEAASIREERG 58
            ||:.......|||..||||       |::..|:        :||..|:|.|:.|:....|:..:|
  Fly     1 MPKPVANQEDEDPTPYLFVSLEQRRIDQSKPYD--------SKKSCWIPDEKEGYLLGEIKATKG 57

Zfish    59 EEVLVELAENGKKAMVNKDDIQKMNPPKFSKVEDMAELTCLNEASVLHNLKDRYYSGLIYTYSGL 123
            :.|.|.| :.|:...:..:.::|:|||||.|:||||::|.||...|||||:.|||:.||||||||
  Fly    58 DIVSVGL-QGGEVRDIKSEKVEKVNPPKFEKIEDMADMTVLNTPCVLHNLRQRYYAKLIYTYSGL 121

Zfish   124 FCVVINPYKNLPIYSENIIEMYRGKKRHEMPPHIYAISESAYRCMLQDREDQSILCTGESGAGKT 188
            |||.|||||..|:|:....:|||||:|:|:||||:|||:.||..||.:..:||:|.|||||||||
  Fly   122 FCVAINPYKRYPVYTNRCAKMYRGKRRNEVPPHIFAISDGAYVDMLTNHVNQSMLITGESGAGKT 186

Zfish   189 ENTKKVIQYLAHVASSHKGRKDHNIPPESPKAVKLQNGILFYGELERQLLQANPILESFGNAKTV 253
            |||||||.|.|.|.:|.|          :.:|.|.:      |.||.|::|.||:||:|||||||
  Fly   187 ENTKKVIAYFATVGASKK----------TDEAAKSK------GSLEDQVVQTNPVLEAFGNAKTV 235

Zfish   254 KNDNSSRFGKFIRINFDVTGYIVGANIETYLLEKSRAIRQAKDERTFHVFYQLLAGAGEHLRS-D 317
            :|||||||||||||:|..||.:.||:||||||||:|.|.|...||::|:|||:::|:...::. .
  Fly   236 RNDNSSRFGKFIRIHFGPTGKLAGADIETYLLEKARVISQQSLERSYHIFYQIMSGSVPGVKDIC 300

Zfish   318 LLLEGFNSYRFLSNGNIPIPGQQDKDNFQETMEAMHIMSFNHEEILSMLKVVSAVLQFGNIVFKK 382
            ||.:....|..:|.|.:.:....|.:.|..|.:|..|:.|..:|...:.::.:||:..|.:.||:
  Fly   301 LLTDNIYDYHIVSQGKVTVASIDDAEEFSLTDQAFDILGFTKQEKEDVYRITAAVMHMGGMKFKQ 365

Zfish   383 ERNTDQASMPENTAAQKLCHLLGMNVMEFTRAILSPRIKVGRDYVQKAQTKEQADFAVEALAKAT 447
            ....:||.........::..|.|.:..|..:.:|.||||||.::|.:.:..:|...::.||.|..
  Fly   366 RGREEQAEQDGEEEGGRVSKLFGCDTAELYKNLLKPRIKVGNEFVTQGRNVQQVTNSIGALCKGV 430

Zfish   448 YERLFRWLVHRINKALDRTKRQGASFIGILDIAGFEIFQLNSFEQLCINYTNEKLQQLFNHTMFI 512
            ::|||:|||.:.|:.|| |:::...|||:|||||||||:.|.|||||||:|||||||.|||.||:
  Fly   431 FDRLFKWLVKKCNETLD-TQQKRQHFIGVLDIAGFEIFEYNGFEQLCINFTNEKLQQFFNHHMFV 494

Zfish   513 LEQEEYQREGIEWSFIDFGLDLQPCIDLIERPANPPGVLALLDEECWFPKATDKTFVDKLVQEQ- 576
            ||||||:||||:|:|||||:||..||||||:|.   |:|::|:||..||||||:||.:||.... 
  Fly   495 LEQEEYKREGIDWAFIDFGMDLLACIDLIEKPM---GILSILEEESMFPKATDQTFSEKLTNTHL 556

Zfish   577 GTHGKFQKPRQLK---DKADFCIIHYAGRVDYKADEWLMKNMDPLNDNVATLLHQSTDKFVAELW 638
            |....||||:..|   ..|.|.|.||||.|.|....||.||.|||||.|.....:|.:|.:.|::
  Fly   557 GKSAPFQKPKPPKPGQQAAHFAIAHYAGCVSYNITGWLEKNKDPLNDTVVDQFKKSQNKLLIEIF 621

Zfish   639 KDEIQNFQRASFYDVSSLHESPGEVDRIVGLDQVAGMNETAFGAAYKTKKGMFRTVGQLYKESLT 703
            .|.                  .|:          :|..|.|.|...| |.|.|.||...|||.|.
  Fly   622 ADH------------------AGQ----------SGGGEQAKGGRGK-KGGGFATVSSAYKEQLN 657

Zfish   704 KLMATLRNTNPNFVRCIIPNHEKRAGKLEPHLVLDQLRCNGVLEGIRICRQGFPNRIVFQEFRQR 768
            .||.|||:|.|:||||||||..|:.|.::.|||:.||.||||||||||||:|||||:::.:|:.|
  Fly   658 SLMTTLRSTQPHFVRCIIPNEMKQPGVVDAHLVMHQLTCNGVLEGIRICRKGFPNRMMYPDFKMR 722

Zfish   769 YEILTPNAIPKGFMDGKQACERMIRALELDPNLYRIGQSKIFFRTGVLAHLEEERDLKITDIIIY 833
            |:|:.|..: :|....|:|.|.:|:.::|..:.||:|.:|:|||.|||..:||.||.::..|:.:
  Fly   723 YKIMCPKLL-QGVEKDKKATEIIIKFIDLPEDQYRLGNTKVFFRAGVLGQMEEFRDERLGKIMSW 786

Zfish   834 FQSVCRGYLARKAFAKKQQQLSALKVLQRNCAAYLKLRHWQWWRLFTKVKPLLQVTRQEEEMQAK 898
            .|:..||||:||.|.|.|:|..||||:|||...||:||.|.|::|:.||||||.|:|.|:|:...
  Fly   787 MQAWARGYLSRKGFKKLQEQRVALKVVQRNLRKYLQLRTWPWYKLWQKVKPLLNVSRIEDEIARL 851

Zfish   899 DEELIKVKE---RQVKVENELVEMERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLVAKKQE 960
            :|:..|.:|   .:|||..||   |..:.:||.||..|.:.|..|.....:.:|..|:|.|:|.:
  Fly   852 EEKAKKAEELHAAEVKVRKEL---EALNAKLLAEKTALLDSLSGEKGALQDYQERNAKLTAQKND 913

Zfish   961 LEEILHDLESRVEEEEERNQSLQNEKKKMQSHIQDLEEQLDEEEAARQKLQLEKVTAEAKIKKME 1025
            ||..|.|::.|:.:||:....|..:|||....|..|::.:::.|...||.:.:|.|.:.:|:.:.
  Fly   914 LENQLRDIQERLTQEEDARNQLFQQKKKADQEISGLKKDIEDLELNVQKAEQDKATKDHQIRNLN 978

Zfish  1026 EDILLLEDQNSKFLKEKKLLEDRVGEMTSQLAEE----EEKAKNLGKVKNKQEMMMVDLEERLKK 1086
            ::|...::..:|..||||:    .||...:..||    |:|..:|.|||.|.|..:.:||:.|::
  Fly   979 DEIAHQDELINKLNKEKKM----QGETNQKTGEELQAAEDKINHLNKVKAKLEQTLDELEDSLER 1039

Zfish  1087 EEKTRQELEKAKRKLDAETTDLQDQIAELQAQIDELKIQLAKKEEELQAVLARGDEEVAQKNNAL 1151
            |:|.|.::||:|||::.:....|:.:|:|:....||:..:.:|::||.::.|:.::|........
  Fly  1040 EKKVRGDVEKSKRKVEGDLKLTQEAVADLERNKKELEQTIQRKDKELSSITAKLEDEQVVVLKHQ 1104

Zfish  1152 KQLRELQAQLAELQEDLESEKAARNKAEKLKRDLSEELEALKTELEDTLDTTAAQQELRSKREQE 1216
            :|::||||::.||:|::|:|:.||.||||.:.||:.|||.|...||:....|:||.||..|||.|
  Fly  1105 RQIKELQARIEELEEEVEAERQARAKAEKQRADLARELEELGERLEEAGGATSAQIELNKKREAE 1169

Zfish  1217 VAELKKAIDDETRNHESQIQEMRQRHGTALEEISEQLEQAKRVKGNLEKNKQTLESDNKELTNEV 1281
            :::|::.:::....|||.:..:|::|..|:.|::||::|..::|...||.|........:|...|
  Fly  1170 LSKLRRDLEEANIQHESTLANLRKKHNDAVAEMAEQVDQLNKLKAKAEKEKNEYYGQLNDLRAGV 1234

Zfish  1282 KSLQQAKSESEHKRKKLEAQLQEVMARFSEGEKVKGELADRTHKIQTELDNVSCLLEDAEKKGIK 1346
            ..:...|:..|...|:|:..|.||.::..|..:...:......|:..|..::...||:||.:..:
  Fly  1235 DHITNEKAAQEKIAKQLQHTLNEVQSKLDETNRTLNDFDASKKKLSIENSDLLRQLEEAESQVSQ 1299

Zfish  1347 LTKDVSSLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNNLLEQQEEEEESRKNLEKQLATLQ 1411
            |:|...||.:||:||:.|..||:|::..|..:.|.||.:.:||.||.|||.|.:.:|::||:...
  Fly  1300 LSKIKISLTTQLEDTKRLADEESRERATLLGKFRNLEHDLDNLREQVEEEAEGKADLQRQLSKAN 1364

Zfish  1412 AQLVETKKKLEDD-VGALEGLEEVKRKLQ---KDMEVTSQKLEEKAIAFDKLEKTKNRLQQELDD 1472
            |:....:.|.|.| |...|.|||.|||||   .:.|.|.:.|.:|.|.   |||||.||..|::|
  Fly  1365 AEAQVWRSKYESDGVARSEELEEAKRKLQARLAEAEETIESLNQKCIG---LEKTKQRLSTEVED 1426

Zfish  1473 LMVDLDHQRQIVSNLEKKQKKFDQMLAEEKTISARYAEERDRAEAEAREKDTKALSMARALDEAL 1537
            |.:::|....|.:..|||||.||:::.|.|......|.|.|.::.|.|...|:...:..|.:|..
  Fly  1427 LQLEVDRANAIANAAEKKQKAFDKIIGEWKLKVDDLAAELDASQKECRNYSTELFRLKGAYEEGQ 1491

Zfish  1538 EAKEEFERLNKQLRAEMEDLISSKDDVGKNVHELEKSKRTLEQQVEEMRTQLEELEDELQATEDA 1602
            |..|...|.||.|..|::||:....:.|:|:||:||:::.||.:.:|::..|||.|..|:..|:.
  Fly  1492 EQLEAVRRENKNLADEVKDLLDQIGEGGRNIHEIEKARKRLEAEKDELQAALEEAEAALEQEENK 1556

Zfish  1603 KLRLEVNMQAMKAQFDRDLQARDEQNEEKKRALVKQVREMEAELEDERKQRALAVAAKKKLEMDL 1667
            .||.::.:..::.:.||.:|.::|:.|..::...:.:..|:|.||.|.|.:|.|:..|||||.|:
  Fly  1557 VLRAQLELSQVRQEIDRRIQEKEEEFENTRKNHQRALDSMQASLEAEAKGKAEALRMKKKLEADI 1621

Zfish  1668 KDVEAQIEAANKARDEAIKQLRKLQAQMKDYQRELEEARTSRDEIFTQSKENEKKLKSLEAEILQ 1732
            .::|..::.||||..||.|.:::.|.|:||.|..|||.:.:||:...|...:|::..:|:.|:.:
  Fly  1622 NELEIALDHANKANAEAQKNIKRYQQQLKDIQTALEEEQRARDDAREQLGISERRANALQNELEE 1686

Zfish  1733 LQEDLASSERARRHAEQERDELADEISNSASGKAALLDEKRRLEARIAQLEEELEE---EQSNME 1794
            .:..|..::|.||.||||..:..::::..::..|::...||:||:.:..|..:|:|   |..|.|
  Fly  1687 SRTLLEQADRGRRQAEQELADAHEQLNEVSAQNASISAAKRKLESELQTLHSDLDELLNEAKNSE 1751

Zfish  1795 LLNDRFRKTTMQVDTLNTELAGERSAAQKSENARQQLERQNKDLKSKLQELEGSVKSKFKASIAA 1859
               ::.:|..:....|..||..|:..||..|..|:.||:|.|:|:.:|.|.|.:.....|.:|..
  Fly  1752 ---EKAKKAMVDAARLADELRAEQDHAQTQEKLRKALEQQIKELQVRLDEAEANALKGGKKAIQK 1813

Zfish  1860 LEAKILQLEEQLEQEAKERAAANKIVRRTEKKLKEVFMQVEDERRHADQYKEQMEKANSRMKQLK 1924
            ||.::.:||.:|:.|.:..|.|.|.:|::|:::||:..|.|::|::.::.::.::|...::|..|
  Fly  1814 LEQRVRELENELDGEQRRHADAQKNLRKSERRVKELSFQSEEDRKNHERMQDLVDKLQQKIKTYK 1878

Zfish  1925 RQLEEAEEEATRANASRRKLQRELDDATEASEGLSREVNTLKNRLRRG 1972
            ||:|||||.|....|..||.|:||::|.|.::...:.::..:.:.|.|
  Fly  1879 RQIEEAEEIAALNLAKFRKAQQELEEAEERADLAEQAISKFRAKGRAG 1926

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
myh10XP_009300420.1 Myosin_N 37..75 CDD:280832 11/37 (30%)
Myosin_head 90..812 CDD:278492 344/726 (47%)
MYSc_Myh10 102..812 CDD:276952 337/714 (47%)
Myosin_tail_1 889..1969 CDD:279860 361/1093 (33%)
DUF342 <1085..1170 CDD:302792 26/84 (31%)
RILP-like <1528..1637 CDD:304877 33/108 (31%)
GBP_C <1641..1734 CDD:303769 36/92 (39%)
coiled coil 1705..1714 CDD:293879 2/8 (25%)
coiled coil 1723..1734 CDD:293879 2/10 (20%)
MhcNP_001162991.1 Myosin_N 36..73 CDD:280832 11/37 (30%)
MYSc 81..777 CDD:214580 357/745 (48%)
MYSc_Myh1_insects_crustaceans 100..765 CDD:276874 337/714 (47%)
Myosin_tail_1 842..1897 CDD:279860 354/1067 (33%)
V_Alix_like 1557..1877 CDD:187408 99/322 (31%)
ATP-synt_B <1671..1771 CDD:304375 26/102 (25%)
TMPIT 1739..>1825 CDD:285135 28/88 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0161
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D47111at2759
OrthoFinder 1 1.000 - - FOG0000014
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100110
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X58
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
65.720

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