DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment PARL and PCP1

DIOPT Version :9

Sequence 1:	XP_005247639.1	Gene:	PARL / 55486	HGNCID:	18253	Length:	394	Species:	Homo sapiens
Sequence 2:	NP_011615.1	Gene:	PCP1 / 852993	SGDID:	S000003333	Length:	346	Species:	Saccharomyces cerevisiae

Alignment Length:	355	Identity:	91/355 - (25%)
Similarity:	141/355 - (39%)	Gaps:	90/355 - (25%)

- Green bases have known domain annotations that are detailed below.

Human    52 GFRKAPR-------KVEPRRSDPGTSGEAYKRSAL--IPPVEETVFYPSPYPIRSLIKPLFFTVG 107
            |.|.|.|       .|.|.|:.....|.:...|.|  .|.:|:.|     ..::.:|...||:
Yeast    10 GLRPATRIFFRSNISVSPSRTFVSYIGRSQSTSILKNAPNLEDNV-----TNLQKIIPKRFFS-- 67

Human   108 FTGCAFGSAAIWQYESLKSRVQSYFDG------IKADWLDSIRPQKEGDFRKEINKWWNNLSDGQ 166
                        |...||||.:..|:.      ::.:.....:.|:.|.         |.|  |.
Yeast    68 ------------QTSILKSRWKPIFNEETTNRYVRLNRFQQYQQQRSGG---------NPL--GS 109

Human   167 RTVTG----------------------------------IIAANVLVFCLWRVPSLQRTMIRYFT 197
            .|:.|                                  ::..||.||.||::|...|.:.:|..
Yeast   110 MTILGLSLMAGIYFGSPYLFEHVPPFTYFKTHPKNLVYALLGINVAVFGLWQLPKCWRFLQKYML 174

Human   198 SNP---ASKVLCSPMLLSTFSHFSLFHMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFV 259
            ...   .||:   .::.|.|||...:|:..||..||||.:|:..:||...|.::|:::.:..:..
Yeast   175 LQKDYVTSKI---SIIGSAFSHQEFWHLGMNMLALWSFGTSLATMLGASNFFSLYMNSAIAGSLF 236

Human   260 S--YVGKVATGRYGPSLGASGAIMTVLAAVCTKIPEGRLAIIFLPMFTFTAGNALKAIIAMDTAG 322
            |  |.........|||||||||:..||.......|..::.:...|: ...|..|..|.:|.:.||
Yeast   237 SLWYPKLARLAIVGPSLGASGALFGVLGCFSYLFPHAKILLFVFPV-PGGAWVAFLASVAWNAAG 300

Human   323 MILGWKFFDHAAHLGGALFGMISLYTWRLA 352
            ..|.|..||:||||||::.|:  ||.|.::
Yeast   301 CALRWGSFDYAAHLGGSMMGV--LYGWYIS 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PARL	XP_005247639.1	Rhomboid	209..351	CDD:279958	51/143 (36%)
PCP1	NP_011615.1	Rhomboid	186..329	CDD:396315	51/146 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C159046884
Domainoid	1	1.000	93	1.000	Domainoid score	I1920
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	107	1.000	Inparanoid score	I1573
Isobase	1	0.950	-	0	Normalized mean entropy	S2377
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005057
OrthoInspector	1	1.000	-	-		oto145069
orthoMCL	1	0.900	-	-		OOG6_101864
Panther	1	1.100	-	-	LDO	PTHR43731
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3580
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.700