Protein Alignment PARL and stet

DIOPT Version :10

• Sequence 1: XP_005247639.1
• Gene: PARL / 55486
• HGNCID: 18253
• Length: 394
• Species: Homo sapiens
• Sequence 2: NP_788450.1
• Gene: stet / 38169
• FlyBaseID: FBgn0020248
• Length: 485
• Species: Drosophila melanogaster
• Alignment Length: 346
• Identity: 71/346 - (20%)
• Similarity: 110/346 - (31%)
• Gaps: 125/346 - (36%)

Human    40 GRRFNFFIQQKCGFRKAPRKV-----------EP---RRSDPGTSGEAYKRSALIPPVEETVFYP 90
            |:|...|   ||......|:|           ||   |:.....:.|      ::|...:..:|.
  Fly   158 GKRTRSF---KCAVHHRDREVCSENDFQLVLNEPPLFRKMVHAVAME------ILPEERDRKYYA 213

Human    91 SPYPIRSLIKPLFFTVGFTGCAFGSAAIWQYESLKSRVQSYFDGIKADWLDSIRPQKEGDFRKEI 155
            ..|   :...|.||.:..|....|   .:.|.|:.:...:....|.:|.:...||.|    |.||
  Fly   214 DRY---TCCPPPFFIILVTLVELG---FFVYHSVVTGEAAPRGPIPSDSMFIYRPDK----RHEI 268

Human   156 NKWWNNLSDGQRTVTGIIAANVLVFCLWRVPSLQRTMIRYFTSNPASKVLCSPMLLSTFSHFSLF 220
                                       ||                        .|.....|....
  Fly   269 ---------------------------WR------------------------FLFYMVLHAGWL 282

Human   221 HMAANMYVLWSFSSSIVNILGQEQFMAVYLSAGVISNFVSYVGKVATGRYGPS---LGASGAIMT 282
            |:..|:.|...|...:..:.|..:...:|.| ||::      |.:.|..:.|.   :||||.:..
  Fly   283 HLGFNVAVQLVFGLPLEMVHGSTRIACIYFS-GVLA------GSLGTSIFDPDVFLVGASGGVYA 340

Human   283 VLAA----VCTKIPEGRLAII-FLPMFTFT------------AGNALK--------AIIAMDTAG 322
            :|||    |.....:.|..:| .|.:..|.            ||:.|:        ||...:|||
  Fly   341 LLAAHLANVLLNYHQMRYGVIKLLHILVFVSFDFGFAIYARYAGDELQLGSSSEFLAIDQAETAG 405

Human   323 MILGWKFFDHAAHLGGALFGM 343
            .:      .:.|||.||:.|:
  Fly   406 AV------SYVAHLAGAIAGL 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PARL	XP_005247639.1	Rhomboid	209..350	CDD:426384	40/163 (25%)
stet	NP_788450.1	EF-hand_7	87..157	CDD:463900
		Rhomboid	262..428	CDD:426384	47/227 (21%)