DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment STRADB and fray

DIOPT Version :10

Sequence 1:NP_061041.2 Gene:STRADB / 55437 HGNCID:13205 Length:418 Species:Homo sapiens
Sequence 2:NP_001303449.2 Gene:fray / 44233 FlyBaseID:FBgn0023083 Length:707 Species:Drosophila melanogaster


Alignment Length:404 Identity:119/404 - (29%)
Similarity:172/404 - (42%) Gaps:101/404 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    19 PEKQSETSI-----------HQYLVDEPTLSWSRPSTRASEVLCSTNVS---------------- 56
            |..||:.:|           |.......|.| ||..|.....|.|.||:                
  Fly   122 PRSQSQPAINNRRRPGTPPPHTVAPGNGTAS-SRSMTSIPANLSSNNVAGAATLPGAAAPPEKYT 185

Human    57 ------HYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCN---EERLKALQKAVILSH 112
                  .|||:..||.|...:  ||.|...|......||..|||..|   :|.||.:|   .:|.
  Fly   186 WPNSKDDYELRDVIGVGATAV--VHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQ---AMSS 245

Human   113 FFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQL----LRT------YFPEGMSETLIRNILFG 167
            .| |.|:.||.|.|.|...||::...:..||...:    :||      .|.|....|:::.:|  
  Fly   246 CF-HENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVL-- 307

Human   168 AVRGLNYLHQNGCIHRSIKASHILISGDGLVTLS--GLSHLHSLVKHGQRHRAVYDFPQFSTSVQ 230
              :||.|.|.||.|||.|||.:|||..||.:.::  |:|...:..:...|.:..:.|    ....
  Fly   308 --KGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTF----VGTP 366

Human   231 PWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFP 295
            .|::||::.|| |||:.|:||:|.||||.|:|:|..|:.            |.||...|.::   
  Fly   367 CWMAPEVMEQD-HGYDFKADIWSFGITAIEMATGTAPYH------------KYPPMKVLMLT--- 415

Human   296 QSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA 360
                 ::|....:|:|..:.                 ...|.:...|..::..|||::|.|||:|
  Fly   416 -----LQNDPPTLDTGADDK-----------------DQYKAYGKTFRKMIVECLQKEPSKRPTA 458

Human   361 SSLLSHVFFKQMKE 374
            |.||.|.|||:.|:
  Fly   459 SELLKHAFFKKAKD 472

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
STRADBNP_061041.2 PK_STRAD_beta 59..386 CDD:270864 104/331 (31%)
frayNP_001303449.2 STKc_OSR1_SPAK 191..467 CDD:270787 101/327 (31%)
OSR1_C 613..670 CDD:463491
Blue background indicates that the domain is not in the aligned region.

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