DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment kdr and btl

DIOPT Version :9

Sequence 1:	NP_001019824.2	Gene:	kdr / 554230	ZFINID:	ZDB-GENE-041001-112	Length:	1357	Species:	Danio rerio
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	1173	Identity:	299/1173 - (25%)
Similarity:	452/1173 - (38%)	Gaps:	358/1173 - (30%)

- Green bases have known domain annotations that are detailed below.

Zfish   218 IVAVVG-----------YKIY-DLTL--SPQHERLTVGERLILNCTAHTERNVGIDFQWTFPHEK 268
            |:|:|.           ::.| |:|:  ||:...|.....:.|.|.....:       | |..:|
  Fly    11 IIAIVSAAADLGCDYGHHRCYIDVTVENSPRQRHLLSDMDITLQCVRPMAK-------W-FYEDK 67

Zfish   269 RSVNGSMSTSRYKTSSNKKKLWNSLELSNTLTVENVTLNDTGEYICTASSGQMQKIAQASLIV-Y 332
            ..:..::                       |.:|.....::|.|.|..|..:...|   ||:| :
  Fly    68 FQLRATL-----------------------LRLERAQSGNSGNYGCLDSQNRWYNI---SLVVGH 106

Zfish   333 EKP-------FIALSD------------------------QLWQTVEAKAG----------DAEA 356
            ::|       |:.|.|                        .|.:||:..||          |.:|
  Fly   107 KEPVGNDIASFVKLEDAPALPESDLFFQPLNESRSLKLLQPLPKTVQRTAGGLFQLNCSPMDPDA 171

Zfish   357 KILVKYYAYPEPAVRWYKNDQLIVLRDGYRMKFYRGVHLTIYGVTEKDAGNYTVVM--------T 413
            |.:         .:.|..||..|:...| |:|..|. .||:..:..:|||:|...:        :
  Fly   172 KGV---------NISWLHNDTQILGGRG-RIKLKRW-SLTVGQLQPEDAGSYHCELCVEQDCQRS 225

Zfish   414 NKITKE--EQRRTFQLVVNDLPRIFEKDVSLDRDVHMYGSSPTLTCTGSGGSSPVTIKWQWMPRE 476
            |....|  .::.|..::....||  ...::|       |.:.::.|.....:....|.|......
  Fly   226 NPTQLEVISRKHTVPMLKPGYPR--NTSIAL-------GDNVSIECLLEDSALEPKITWLHKGNA 281

Zfish   477 DCPVRFLPK-SDPSMAKCDKWREMSNNTGKNPLISQTSVDERTLKTISTLKIQKAVDHALYRCIA 540
            |.....|.: .:.|....|..|          ||  |.:||..:..:..:.::   |...|.|||
  Fly   282 DNIDDLLQRLREQSQLPVDVTR----------LI--TRMDEPQVLRLGNVLME---DGGWYICIA 331

Zfish   541 TNKMGQ------------DQRVIVFQVTRFLNLSVLPSSSPIEGQDVIMRCVADRLLYYNLRWYR 593
            .|::|:            .....|...|.....|.:|::|..|..|                 ..
  Fly   332 ENQVGRTVAASYVDLYSPSDTTTVRTTTTTTVASPIPTASTGEDND-----------------DD 379

Zfish   594 VANVANHDPPPAAVPCDTLTLSHLHQPNVTVSGLQGTNVTLDMPI-------------------- 638
            |.|.|.........|.....|..|..      .|.|..|.|..|:
  Fly   380 VENPAAEASGGVGPPVFRKELKRLQH------SLSGNTVNLACPVYGKANITWTKDKKPLNRELG 438

Zfish   639 -----------PNATMMDQGLYACQVEIVGTNEKTCLLHNLRLRALEMSR---IVTNLTDQRVNV 689
                       ..||..|.|||.|:|    .|...|:..:..::..:.:|   |:....:|.|.|
  Fly   439 VYVQKNWTLRFVEATSEDSGLYNCKV----CNAWGCIQFDFSVQINDRTRSAPIIVVPQNQTVKV 499

Zfish   690 SDSTTLVCEVSGTPTPTIVWTKDNQTVMEGSGVILKRSNR--------------------VLTIQ 734
            :.|..:.|.|.....||:.|.:          |:||.::.                    |||::
  Fly   500 NGSLVMKCTVYSDLHPTVSWKR----------VVLKNASLDGLKSVEIQNLNFTVTNDSVVLTLR 554

Zfish   735 RVKKEDSGLYICTACNQQGCESSEARISVDGAEEKMNVELIM---PIG-----AVVIAMFLW--L 789
            .|..:..|.|.|.|.:..|..:|...:.|......:.:..::   |:|     ..::|:||.  .
  Fly   555 NVTFDQEGWYTCLASSGLGRSNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIVALFLLGSA 619

Zfish   790 LIVFVIRNRKRP------------------------------NDGDLKTGYLSII---------- 814
            .|.|::|..:|.                              :.|||:...:.|.
  Fly   620 FITFMLRRLRREKLLKLRIETVHQWTKKVIIYRPGGEEGSGCSSGDLQMPVIRIEKQRTTVSTTG 684

Zfish   815 ---------LDSDDMPMDEHCERLTYDASKWEFPRDRLKLGEPLGRGAFGQVVEATAYGIEKATT 870
                     .:..:.|:|          |.||.||.:|.||..||.||||:||.|.|.|:.::..
  Fly   685 TGGTDPAQGFNEYEFPLD----------SNWEIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQ 739

Zfish   871 C--TTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTKQGGPLMVIVEYCKHGNL 933
            .  |.|||||:||..|.::..:|:.|::::..||.|:|::||||.|: |||||.|||||..||||
  Fly   740 LAETIVAVKMVKEEHTDTDMASLVREMEVMKMIGKHINIINLLGCCS-QGGPLWVIVEYAPHGNL 803

Zfish   934 SSYLKSKRGEYSPYKKRTPRMPNRREVQQDEDPREGDLGLGTSTRLDICTGTAVCTRTGEQTSTT 998
            ..:||..|          |..|.||   .|.|   |.|
  Fly   804 KDFLKQNR----------PGAPQRR---SDSD---GYL--------------------------- 825

Zfish   999 LQDEQESSDWDHLTMEDLISYSFQVAKGMEFLASRKCIHRDLAARNILLSENSVVKICDFGLARD 1063
              |::......||..::|..::||:|:|||:||||:||||||||||:|:|:..|:||.|||||||
  Fly   826 --DDKPLISTQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARD 888

Zfish  1064 VYKDPDYVRKG-DARLPLKWMAPETIFDRVYTTQSDVWSFGVLLWEIFSLGASPYPGVCIDESFC 1127
            : :|.:|.||. :.|||:||||||::.::.|.:||||||:|||||||.:.|..|||.:...|...
  Fly   889 I-QDTEYYRKNTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELY 952

Zfish  1128 RRLKEGTRMRAPDYATPEIYQTMLDCWLDRPLDRPTFTQLVEHLGNLLQASAQQDGKDYIPLTNG 1192
            ..|..|.||..|...:..||..|..||......||||.:|||....:||.::......|:.|:..
  Fly   953 SYLITGQRMEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMP 1017

Zfish  1193 EME 1195
            .:|
  Fly  1018 MLE 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
kdr	NP_001019824.2	Ig_2	143..221	CDD:290606	1/2 (50%)
		IG_like	233..331	CDD:214653	16/97 (16%)
		Ig	241..335	CDD:299845	15/94 (16%)
		IG_like	345..429	CDD:214653	24/103 (23%)
		Ig2_VEGFR-2	356..429	CDD:143272	19/82 (23%)
		IG	571..654	CDD:214652	20/113 (18%)
		Ig	571..654	CDD:299845	20/113 (18%)
		I-set	677..763	CDD:254352	24/108 (22%)
		IGc2	691..753	CDD:197706	17/81 (21%)
		PKc_like	835..1178	CDD:304357	150/345 (43%)
		Pkinase_Tyr	843..1171	CDD:285015	144/330 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	944..975		8/30 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1296..1357
btl	NP_001014583.1	IG_like	149..232	CDD:214653	22/93 (24%)
		IGc2	157..215	CDD:197706	18/68 (26%)
		IG	247..336	CDD:214652	23/112 (21%)
		Ig	258..340	CDD:143165	20/96 (21%)
		I-set	394..479	CDD:254352	18/94 (19%)
		IGc2	408..469	CDD:197706	13/64 (20%)
		IG_like	492..583	CDD:214653	22/100 (22%)
		Ig	507..583	CDD:299845	18/85 (21%)
		PKc_like	700..1000	CDD:304357	151/356 (42%)
		TyrKc	712..996	CDD:197581	144/330 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810