DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIRPG and Sirpb1b

DIOPT Version :9

Sequence 1:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens
Sequence 2:	XP_006530146.1	Gene:	Sirpb1b / 668101	MGIID:	3779828	Length:	408	Species:	Mus musculus

Alignment Length:	402	Identity:	220/402 - (54%)
Similarity:	282/402 - (70%)	Gaps:	23/402 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     6 SWPHPPGPFLLLTLLLGLTEVAGEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGV 70
            :|.|.|...|||.||||| :.|...||::|||.|...|..|.:|||:|||||||||||:.|:|||
Mouse     6 AWTHIPHSVLLLILLLGL-KGAAMRELKVIQPVKSFFVGAGGSATLNCTVTSLLPVGPIRWYRGV 69

Human    71 GPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPE-NVEFKS 134
            |..|.||.:....||||:|:|||:|||||:|||||||::||||.||||||||::||.| :.|.:|
Mouse    70 GQSRLLIQSFTGEHFPRITSVSDVTKRNNLDFSIRISNVTPADSGTYYCVKFQRGSSESDREIQS 134

Human   135 GPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPT 199
            |.|||:::.||||:|:|.|||||..|:.||:|||.||||.||::||||||||||:|..:|:|:|.
Mouse   135 GGGTELSVLAKPSSPMVSGPAARAVPKQTVTFTCRSHGFFPRNLTLKWFKNGNEISHLETSVEPE 199

Human   200 GQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVG 264
            ..||:|.:.||.:|||:|.|||||:||||.||||...||||.|::||.|:||||||::|||..|.
Mouse   200 ETSVSYRVSSTVQVVLEPRDVRSQIICEVDHVTLDRAPLRGIAHISEFIQVPPTLEISQQPTMVW 264

Human   265 NQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTC 329
            |.:.||||::||||...|:||.||||:.:||...||..||||||||.|..|||||...:::|:||
Mouse   265 NVIIVTCQIQKFYPPRFQVTWLENGNISRREVPFTLIVNKDGTYNWISCLLVNISALEENMVVTC 329

Human   330 QVKHDGQLAVSKRLALEVTVHQKDQSSDATPGPASSLTALLL-----------IAVLLGP----- 378
            ||:||||..|.:...:.||.||:.:.:..|.....:|..:|.           :|||||.
Mouse   330 QVEHDGQAEVIETHTVVVTEHQRVKGTLQTTITEENLKNVLYELKTAGIAKIPVAVLLGSKILLL 394

Human   379 -----IYVPWKQ 385
                 ||:..||
Mouse   395 IAATVIYMHKKQ 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346	69/110 (63%)
		IgC_SIRP_domain_2	145..248	CDD:319314	65/102 (64%)
		IgC_SIRP_domain_3	250..353	CDD:319334	58/102 (57%)
Sirpb1b	XP_006530146.1	Ig	32..143	CDD:386229	69/110 (63%)
		IgC_SIRP_domain_2	145..248	CDD:319314	65/102 (64%)
		IgC_SIRP_domain_3	250..352	CDD:319334	57/101 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83971945
Domainoid	1	1.000	146	1.000	Domainoid score	I34754
eggNOG	1	0.900	-	-		E1_2BRY5
HGNC	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	449	1.000	Inparanoid score	I12964
Isobase	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG36121
OrthoDB	1	1.010	-	-		D114611at9347
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19971
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1115
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.870