DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIRPG and nitr1i

DIOPT Version :9

Sequence 1:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_571721.1	Gene:	nitr1i / 60644	ZFINID:	ZDB-GENE-001106-3	Length:	335	Species:	Danio rerio

Alignment Length:	234	Identity:	58/234 - (24%)
Similarity:	87/234 - (37%)	Gaps:	57/234 - (24%)

- Green bases have known domain annotations that are detailed below.

Human    12 GPFLLLT----LLLGLTEVAGEEELQMIQPEKLLLVTVGKTATLHCTV---TSLLPVGPVLWFRG 69
            |..|::|    |||..| :....:..::|.:.:.:|..|......||.   |.|..|    ||:.
Zfish    11 GRRLIVTCYFILLLSST-IFCSTDFDVVQEDNVKIVKAGWDVKFTCTFSWHTQLKKV----WFKQ 70

Human    70 VGPGREL----IY-NQKEGHFPRV--TTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSP 127
            ...|:.|    :| :||....|:.  |...:..|.:|. |::.|...|.:|..|||||
Zfish    71 TNNGKSLQIVSLYGSQKPSWNPKFEKTNRFNAAKGDNF-FNLTILKTTLSDSATYYCV------- 127

Human   128 ENVEFKSGPGTEMALGAKPSAPVVLGPAARTT-----------PEHTVSFTCESHGFS-PRDITL 180
                ..|...|.|..|.:  ..|....|.|.|           |..:|:..|.....| ..|.::
Zfish   128 ----VSSYQATGMGSGTR--LLVRDADADRNTTLHQSLIDAVDPGDSVNLQCSIFTESCAGDHSI 186

Human   181 KWFK--NGNELSDFQTNVDPTG----------QSVAYSI 207
            .|||  :|:.:....|..:..|          ||..||:
Zfish   187 YWFKQISGDSVGLIYTKGERNGRCKNSTESQTQSCVYSL 225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346	31/119 (26%)
		IgC_SIRP_domain_2	145..248	CDD:319314	19/87 (22%)
		IgC_SIRP_domain_3	250..353	CDD:319334
nitr1i	NP_571721.1	V-set	45..145	CDD:284989	31/117 (26%)
		IG_like	45..144	CDD:214653	31/116 (27%)
		IG_like	163..242	CDD:214653	15/63 (24%)
		V-set	165..259	CDD:284989	15/61 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm28671
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910