DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIRPG and side

DIOPT Version :9

Sequence 1:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_001247334.1	Gene:	side / 43300	FlyBaseID:	FBgn0016061	Length:	986	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	95/407 - (23%)
Similarity:	161/407 - (39%)	Gaps:	84/407 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    15 LLLTLLLGLTEVAGEEELQMIQ---PEKLLLVTVGKTATLHCTV---TSLLPVGPVLWFRGVGPG 73
            :|||.|..|..|:.:||.|..|   |.:|:...:|||..|.|.:   ||...|..:|||:.. .|
  Fly    71 VLLTCLQQLKSVSADEESQDFQKNIPARLVWAALGKTVELPCDLTPPTSQDSVKLLLWFKDT-TG 134

Human    74 RELIYNQKEGH----FPRVTTVSDLTKR-------NNMDFSIRISSITPADVGTYYCVKFRKGSP 127
            ..|......|.    .|.....|||.:|       |..|..::|:.:.|.|.|.|.|
  Fly   135 IPLYSLDSRGGNVKLAPHAAIASDLGQRLFFSIGDNPKDSRLQINDVKPEDGGVYRC-------- 191

Human   128 ENVEFKSGPGT----EMALGAKPSAPVVLGPAARTTPE--------HTVSFTCESHGFSPRDITL 180
             .|:|.:.|..    .:.|...|..|.:.....:...:        :.:...|:..|..|.. .:
  Fly   192 -RVDFFNSPTRNFRHNLTLVVPPEEPRIFDAQGKEISQMAGPFREGYELFLCCQVRGGRPPP-KV 254

Human   181 KWFKNGNEL-SDFQTNVDPTGQSVAYS---IRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGT 241
            .|:::..|| ....|:|: .|.:|..:   |.:|.|   |.:.:|  :.|..          :||
  Fly   255 TWWRDDTELIGTSHTSVE-EGATVMVNQLLIGTTTR---DFYGIR--IECRA----------QGT 303

Human   242 ANLSEAIRVPPTLEVTQQPMRV-----------GNQVNVTCQVRKFYPQSLQLTWSENGNVCQRE 295
             .|.:.:|...|::|..:|:||           |..:.:.|:....|| :.::||..:|...:..
  Fly   304 -RLVDPVRKDVTVQVYLKPVRVKIATPNELLTAGQPMPIRCESWGSYP-AAKITWLLDGEPIRNA 366

Human   296 TASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKH---DGQLAVSKRLAL-----EVTVH-- 350
            ..:..::.:||... ||...:.::.:.|:..|||:..:   .|.....||:..     .|:||
  Fly   367 EVTVHSDKEDGNIT-TSILTLKVTSENDNAELTCRATNPWFSGGAIEDKRIIRVAYPPTVSVHLA 430

Human   351 QKDQSSDATPGPASSLT 367
            .:|.|...|.....::|
  Fly   431 NEDPSRLVTRAEGQNVT 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346	34/130 (26%)
		IgC_SIRP_domain_2	145..248	CDD:319314	21/114 (18%)
		IgC_SIRP_domain_3	250..353	CDD:319334	26/123 (21%)
side	NP_001247334.1	V-set	95..211	CDD:284989	33/125 (26%)
		IG_like	100..211	CDD:214653	31/120 (26%)
		Ig	235..301	CDD:299845	16/82 (20%)
		Ig	326..408	CDD:299845	15/83 (18%)
		IG_like	329..407	CDD:214653	15/79 (19%)
		IG_like	435..511	CDD:214653	3/13 (23%)
		Ig_2	442..511	CDD:290606	1/6 (17%)
		FN3	<700..735	CDD:238020
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910