DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SIRPG and beat-Vb

DIOPT Version :9

Sequence 1:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_001262511.1	Gene:	beat-Vb / 41583	FlyBaseID:	FBgn0038092	Length:	328	Species:	Drosophila melanogaster

Alignment Length:	272	Identity:	63/272 - (23%)
Similarity:	98/272 - (36%)	Gaps:	75/272 - (27%)

- Green bases have known domain annotations that are detailed below.

Human   164 VSFTCESHGFSPRDI-TLKWFKNGNELSDFQTNVDPTGQSVAYSI-------------RSTARVV 214
            |:.:| |:..|...: ::||:|||.|...:.....||  .:.:::             .|:.||.
  Fly    41 VTLSC-SYDISGHTLNSVKWYKNGKEFFRYSPLTPPT--YIPFAVEGVQLIDDGNECNESSCRVE 102

Human   215 LDPWDVRSQVI--CEVA----HVTLQGDPLRGTANLS-EAI-RVPPTLEVTQQPMRVGNQVNVTC 271
            |:...|:|..:  |||:    |..|..    ..||:: ||: :..|.:.......|..:.|.|.|
  Fly   103 LNLLGVKSSGVYRCEVSGDAPHFQLTA----RDANMTVEALPQNNPLISSFHSTYRFNDFVEVNC 163

Human   272 QVRKFYPQSLQLTWSENG-------------------NVCQRETASTLT--ENKDGTYNWTSWFL 315
            .. .|.....::||..||                   ....|...|.|.  .|:...:......|
  Fly   164 ST-DFSSLFTRITWYVNGIKVSLVDLLPSFETTIVAHGYSMRRIVSQLNFYANEPRFHQLQLQKL 227

Human   316 V----NISDQRDDVVLTCQVKHDGQLAVSKRLALEVT---------VHQKDQS-----SDATPGP 362
            :    .||..|..:.|.|..:.|..    ..|..|.|         :.||:|.     |.|||.
  Fly   228 IQQKRTISPARLGLELRCVAEIDRY----PHLQREGTMFAQLFRDDIDQKNQKLINSRSGATPN- 287

Human   363 ASSLTALLLIAV 374
             |.:..|||:|:
  Fly   288 -SQVQHLLLVAI 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346
		IgC_SIRP_domain_2	145..248	CDD:319314	26/104 (25%)
		IgC_SIRP_domain_3	250..353	CDD:319334	25/136 (18%)
beat-Vb	NP_001262511.1	IG_like	39..121	CDD:214653	21/82 (26%)
beat-Vb	NP_001262511.1	Ig	41..130	CDD:143165	23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910