DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIRPG and side-VII

DIOPT Version :9

Sequence 1:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens
Sequence 2:	NP_001262432.1	Gene:	side-VII / 41184	FlyBaseID:	FBgn0037736	Length:	939	Species:	Drosophila melanogaster

Alignment Length:	372	Identity:	81/372 - (21%)
Similarity:	135/372 - (36%)	Gaps:	112/372 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    15 LLLTLLLGLTEVA-GEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGP--VLWFR-------- 68
            ||..|.|.|.|.: |.:::.:.|.|.:    ||:...|.|.||:.....|  |||:|
  Fly     5 LLFMLALQLIESSIGSKDVPIHQIESI----VGENIYLPCNVTTYDGDEPVLVLWYRDDKGTPIY 65

Human    69 ------GV-------------GPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADV 114
                  ||             |.....|::::.|                   .:.|.:...:|.
  Fly    66 SIDIRAGVSKAPKRWSDDSVFGDRAYFIFDKEPG-------------------KLSIQNTQASDS 111

Human   115 GTYYC-VKFRKGS-------------PENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVS 165
            |||.| |.|.|..             |:.|..:.....|.:        .|:||.:.   ...||
  Fly   112 GTYRCRVDFLKAQTINSRIRLNVISPPKQVIIRDSSNVERS--------TVVGPYSE---GDIVS 165

Human   166 FTCESHGFSPRDITLKWFKNGNELS------------DFQTNVDPTGQSVAYSIRSTARVVLDPW 218
            ..|:..|..|.. |:.|:::|.|:.            :.:..:...|:....| |.|.|.:..|
  Fly   166 LKCQVIGGYPTP-TISWYRDGIEIPCELSHLAGGKIIECEITLPSLGREDLNS-RLTCRALSHP- 227

Human   219 DVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFYPQSLQL 283
              |:.::..|..:.:...||.        ||    |....||:..|.:.::.||.....|.:: :
  Fly   228 --RAPIVEAVVQIDMNFAPLN--------IR----LLGAHQPLSAGRRYDLLCQSAGSRPPAV-I 277

Human   284 TWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQ 330
            ||.:||...::.|.:|   :.||... ||...:::|.......|:|:
  Fly   278 TWWQNGIRLEKTTETT---SSDGNQT-TSTLSISLSKSDAGKYLSCK 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346	30/152 (20%)
		IgC_SIRP_domain_2	145..248	CDD:319314	22/114 (19%)
		IgC_SIRP_domain_3	250..353	CDD:319334	20/81 (25%)
side-VII	NP_001262432.1	IG_like	32..134	CDD:214653	25/120 (21%)
		V-set	32..134	CDD:284989	25/120 (21%)
		IGc2	160..>214	CDD:197706	10/57 (18%)
		Ig	262..328	CDD:299845	16/64 (25%)
		IG_like	264..323	CDD:214653	16/62 (26%)
		IGc2	360..425	CDD:197706
		Ig_3	456..519	CDD:290638
		FN3	538..620	CDD:238020
		FAM176	643..741	CDD:291517
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910