DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SIRPG and Sirpa

DIOPT Version :9

Sequence 1:	NP_061026.2	Gene:	SIRPG / 55423	HGNCID:	15757	Length:	387	Species:	Homo sapiens
Sequence 2:	XP_006235013.1	Gene:	Sirpa / 25528	RGDID:	3449	Length:	513	Species:	Rattus norvegicus

Alignment Length:	391	Identity:	201/391 - (51%)
Similarity:	259/391 - (66%)	Gaps:	22/391 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     4 PASWPHPPGPFLLLTLLLGLTEVAGE--EELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLW 66
            ||  |...||.|...||......||.  :||::.|.:|.:.|..|.:|||:|||:||.||||:.|
  Rat     6 PA--PGRLGPLLFCLLLSASCFCAGASGKELKVTQADKSVSVAAGDSATLNCTVSSLTPVGPIKW 68

Human    67 FRGVGPGRELIYNQKEG-HFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPE-N 129
            |:|.|..|..||:...| ||||:|.|||.||||||||||.||::||.|.||||||||:||..| :
  Rat    69 FKGEGQNRSPIYSFIGGEHFPRITNVSDATKRNNMDFSICISNVTPEDAGTYYCVKFQKGIVEPD 133

Human   130 VEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQT 194
            .|.|||.||.:.:.||||:|.|.||.:|.:|..||:|||:|:|||||:|||||.|:|.|||..:|
  Rat   134 TEIKSGGGTTLYVLAKPSSPEVSGPDSRGSPGQTVNFTCKSYGFSPRNITLKWLKDGKELSHLET 198

Human   195 NVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQ 259
            .:. :..:|:|:|.||..|.|.|.|:.|:||||||||||:|.||.||||.|..|||.|||::|||
  Rat   199 TIS-SKSNVSYNISSTVSVKLSPEDIHSRVICEVAHVTLEGRPLNGTANFSNIIRVSPTLKITQQ 262

Human   260 PMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDD 324
            |:...:|||:||||:||||::|||.|.||||:.:.:.....|:|:|||||:||.||||.|..|:|
  Rat   263 PLTPASQVNLTCQVQKFYPKALQLNWLENGNLSRTDKPEHFTDNRDGTYNYTSLFLVNSSAHRED 327

Human   325 VVLTCQVKHDGQLAVSKRLALEVTVHQKDQSSDAT---------------PGPASSLTALLLIAV 374
            ||.||||:||.|.|:::...:....|.....|..|               .|.|.:|..:||:|.
  Rat   328 VVFTCQVEHDSQPAITENHTVRAFAHSSSGGSMETIPDNNAYYNWNVFIGVGVACALLVVLLMAA 392

Human   375 L 375
            |
  Rat   393 L 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SIRPG	NP_061026.2	IgV_SIRP	33..143	CDD:319346	64/111 (58%)
		IgC_SIRP_domain_2	145..248	CDD:319314	59/102 (58%)
		IgC_SIRP_domain_3	250..353	CDD:319334	54/102 (53%)
Sirpa	XP_006235013.1	V-set	38..147	CDD:284989	64/108 (59%)
		IG_like	41..146	CDD:214653	63/104 (61%)
		Ig	146..255	CDD:299845	63/109 (58%)
		IG_like	158..>222	CDD:214653	33/64 (52%)
		IgC	266..344	CDD:143166	45/77 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83695254
Domainoid	1	1.000	142	1.000	Domainoid score	I33677
eggNOG	1	0.900	-	-		E1_2BRY5
HGNC	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG36121
OrthoDB	1	1.010	-	-		D114611at9347
OrthoFinder	1	1.000	-	-		FOG0012483
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR19971
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1115
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.820