Protein Alignment NPY4R and sNPF-R

DIOPT Version :10

• Sequence 1: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Sequence 2: NP_524176.1
• Gene: sNPF-R / 40195
• FlyBaseID: FBgn0036934
• Length: 600
• Species: Drosophila melanogaster
• Alignment Length: 355
• Identity: 112/355 - (31%)
• Similarity: 169/355 - (47%)
• Gaps: 60/355 - (16%)

Human    40 VMVFIVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLAFSDFLMCLLCQPLTAVYTIM 104
            |.:|....|:...|:||.||:.:..|.:|.:....|||:.|.|||.||.|:|:|..|.|.:||.|
  Fly    62 VQIFFYVLYATVFVLGVFGNVLVCYVVLRNRAMQTVTNIFITNLALSDILLCVLAVPFTPLYTFM 126

Human   105 DYWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTGWKPSISQAYLGIVLIWVIACV 169
            ..|.||.:||.:.:|.|..|:.:|.|:|..:|::|:.:||.|...:..:|.....||.|||||.:
  Fly   127 GRWAFGRSLCHLVSFAQGCSIYISTLTLTSIAIDRYFVIIYPFHPRMKLSTCIGIIVSIWVIALL 191

Human   170 LSLPF---------LAN-------SILENVFHKNHSKALEFLAD--------------------- 197
            .::|:         |.|       :::|.....|.|    |:|.
  Fly   192 ATVPYGMYMKMTNELVNGTQTGNETLVEATLMLNGS----FVAQGSGFIEAPDSTSATQAYMQVM 252

Human   198 ------------KVVCTESWPLAHHRTIYTTFLLLFQYCLPLGFILVCYARIYRCLQRQGRVFHK 250
                        :|.|.|:||...:|.::.......|:.||...|.:||..|...|.::.|. ..
  Fly   253 TAGSTGPEMPYVRVYCEENWPSEQYRKVFGAITTTLQFVLPFFIISICYVWISVKLNQRARA-KP 316

Human   251 GTYSLR-----AGHMKQVNVVLVVMVVAFAVLWLPLHVFNSLEDWHHEAIPICHGNLIFLVCHLL 310
            |:.|.|     ....|:.|.:|:.||..|.:.|||::|.|..:|:..::.......|.|.|.|.:
  Fly   317 GSKSSRREEADRDRKKRTNRMLIAMVAVFGLSWLPINVVNIFDDFDDKSNEWRFYILFFFVAHSI 381

Human   311 AMASTCVNPFIYGFLNTNFKKEIKALVLTC 340
            ||:|||.|||:|.:||.||:||.|. ||.|
  Fly   382 AMSSTCYNPFLYAWLNENFRKEFKH-VLPC 410

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	106/344 (31%)
		TM helix 1	43..69	CDD:320519	8/25 (32%)
		TM helix 2	76..101	CDD:320519	13/24 (54%)
		TM helix 3	114..144	CDD:320519	9/29 (31%)
		TM helix 4	155..176	CDD:320519	8/29 (28%)
		TM helix 5	211..240	CDD:320519	8/28 (29%)
		TM helix 6	258..288	CDD:320519	11/29 (38%)
		TM helix 7	301..326	CDD:320519	13/24 (54%)
sNPF-R	NP_524176.1	7tmA_NPYR-like	64..404	CDD:320331	106/344 (31%)
		TM helix 1	65..91	CDD:320331	8/25 (32%)
		TM helix 2	98..123	CDD:320331	13/24 (54%)
		TM helix 3	136..166	CDD:320331	9/29 (31%)
		TM helix 4	177..198	CDD:320331	8/20 (40%)
		TM helix 5	278..307	CDD:320331	8/28 (29%)
		TM helix 6	329..359	CDD:320331	11/29 (38%)
		TM helix 7	372..397	CDD:320331	13/24 (54%)