Protein Alignment NPY4R and npr-12

DIOPT Version :10

• Sequence 1: NP_005963.4
• Gene: NPY4R / 5540
• HGNCID: 9329
• Length: 375
• Species: Homo sapiens
• Sequence 2: NP_001293732.1
• Gene: npr-12 / 188742
• WormBaseID: WBGene00020689
• Length: 397
• Species: Caenorhabditis elegans
• Alignment Length: 338
• Identity: 100/338 - (29%)
• Similarity: 175/338 - (51%)
• Gaps: 41/338 - (12%)

Human    33 HC---------QDSVDVMVF----IVTSYSIETVVGVLGNLCLMCVTVRQKEKANVTNLLIANLA 84
            ||         |:|:..:.|    ||..|.:....|.|.|..::...||.....|:.|..|.|||
 Worm    20 HCDWFAEMQNYQNSLYKINFDGSPIVPMYGLVCSFGALANFIVLLAFVRTANLRNLRNSFIVNLA 84

Human    85 FSDFLMCLLCQPLTAVYTIMD-YWIFGETLCKMSAFIQCMSVTVSILSLVLVALERHQLIINPTG 148
            |||.::|::..|:| :||.:: :|.||:..||..|.:|.::..||.|:|..:|::|..|.:.|..
 Worm    85 FSDLILCVVTAPVT-LYTSLNLFWPFGDWSCKFLAGVQAVNTFVSSLTLAFIAMDRVLLTLCPVR 148

Human   149 WKPSISQAYLGIVLIWVIACVLSLPF-LANSILENVF----HKNHSKALEFLADKV--VCT---E 203
            |:.:.:...|...::|:|:.:::||: ||.|.....|    .:...|.|.:...:|  :|.   |
 Worm   149 WRLAATAPLLCYGVVWIISIIVALPYALAVSSKLAPFDPWSDRATPKMLTYCNRQVPEICAEMQE 213

Human   204 SWPLA-HHRTIYTTFLLLFQYCLPLGFILVCYARIYRCLQRQGRVFHKGTYSLRAGHMKQVN--- 264
            :|..| ..:|.||..:|..||.|||..:...|.:|...:|::.:| .:...:.|...|:..|
 Worm   214 AWDNAIVSKTTYTFVVLGIQYILPLAALAYAYFQIGSTIQKRSKV-SRTVDTTRRMQMQNRNRRA 277

Human   265 -VVLVVMVVAFAVLWLPL---HVFNSLEDWHHEAIPICHGNLIFLVCHLLAMASTCVNPFIYGFL 325
             ::|.::|:.:||.|.|:   ||.|.||       .|.:...:::.|||:.::||||||.:|..:
 Worm   278 LLLLFLLVLTYAVCWAPMNIYHVLNGLE-------IINYSQNMYIFCHLVGISSTCVNPIVYALV 335

Human   326 NTNFKKEIKALVL 338
            |.:|:..:::::|
 Worm   336 NESFRNALQSMIL 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
NPY4R	NP_005963.4	7tmA_NPY4R	42..333	CDD:320519	95/313 (30%)
		TM helix 1	43..69	CDD:320519	8/29 (28%)
		TM helix 2	76..101	CDD:320519	11/24 (46%)
		TM helix 3	114..144	CDD:320519	11/29 (38%)
		TM helix 4	155..176	CDD:320519	5/21 (24%)
		TM helix 5	211..240	CDD:320519	11/28 (39%)
		TM helix 6	258..288	CDD:320519	11/36 (31%)
		TM helix 7	301..326	CDD:320519	10/24 (42%)
npr-12	NP_001293732.1	7tmA_NPYR-like	42..343	CDD:320331	94/309 (30%)
		TM helix 1	43..69	CDD:320331	7/25 (28%)
		TM helix 2	76..101	CDD:320331	11/25 (44%)
		TM helix 3	114..144	CDD:320331	11/29 (38%)
		TM helix 4	155..176	CDD:320331	5/20 (25%)
		TM helix 5	222..251	CDD:320331	11/28 (39%)
		TM helix 6	272..302	CDD:320331	9/29 (31%)
		TM helix 7	311..336	CDD:320331	10/24 (42%)