DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment AVPR2 and CCAP-R

DIOPT Version :9

Sequence 1:	NP_000045.1	Gene:	AVPR2 / 554	HGNCID:	897	Length:	371	Species:	Homo sapiens
Sequence 2:	NP_001368957.1	Gene:	CCAP-R / 2768688	FlyBaseID:	FBgn0039396	Length:	521	Species:	Drosophila melanogaster

Alignment Length:	381	Identity:	117/381 - (30%)
Similarity:	175/381 - (45%)	Gaps:	33/381 - (8%)

- Green bases have known domain annotations that are detailed below.

Human     7 TSAVPGHPSLPSLPSNSSQERPLDTRDP--LLARAELALLSIVFVAVALSNGLVLAAL-ARRGRR 68
            |:|.|.|.......|.||.....|..:.  .....:.|:|.|:|..:.|.|..||..: ..:.|:
  Fly    91 TTAAPSHDLETGGNSTSSDPGEFDNLNSFYFYETEQFAVLWILFTVIVLGNSAVLFVMFINKNRK 155

Human    69 GHWAPIHVFIGHLCLADLAVALFQVLPQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAM 133
            ..   ::.||..|.||||.|.|..||..:.|:.|..:|..:..|:|:::.|:...|:|:|:::||
  Fly   156 SR---MNYFIKQLALADLCVGLLNVLTDIIWRITISWRAGNLACKAIRFSQVCVTYSSTYVLVAM 217

Human   134 TLDRHRAICRPMLAYRHGSGAHWNRP---VLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWAC 195
            ::||:.||..||     .....|.|.   |..||..|.|.|||.|.::.::.::|.   ..||..
  Fly   218 SIDRYDAITHPM-----NFSKSWKRARHLVAGAWLISALFSLPILVLYEEKLIQGH---PQCWIE 274

Human   196 FAEPWGRRTYVTWIALMVFVAPTLGIAACQVLIFREIHA-SLVPGPSERPG-GRRRGRRTGSPGE 258
            ...|...:.|::.::..:|..|.|.|:||..:|.:.|.| ..:..|:||.| |....||..|.|
  Fly   275 LGSPIAWQVYMSLVSATLFAIPALIISACYAIIVKTIWAKGSIFVPTERAGFGAAPARRASSRG- 338

Human   259 GAHVSAAVAKTVRMTLVIVVVYVLCWAPFFLVQLWAAWD--PEAPLEGAPFVLLMLLASLNSCTN 321
              .:..|..|||:|||.||.|:::||:|:.:..|...:.  |.:....|....:..||.|||..|
  Fly   339 --IIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIPHSQTNIAIATFIQSLAPLNSAAN 401

Human   322 PWIYASFSSSVSSEL------RSLLCCARGRTPPSLGPQDESCTTASSSLAKDTSS 371
            |.||..|||.|...|      :...||.:.....|   |...|.|....|.....|
  Fly   402 PLIYCLFSSQVFRTLSRFPPFKWFTCCCKSYRNNS---QQNRCHTVGRRLHNSCDS 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AVPR2	NP_000045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		7/22 (32%)
		7tmA_V2R	45..326	CDD:320510	93/288 (32%)
		TM helix 2	74..101	CDD:320510	12/26 (46%)
		TM helix 3	112..142	CDD:320510	11/29 (38%)
		TM helix 4	155..176	CDD:320510	10/23 (43%)
		TM helix 5	202..231	CDD:320510	8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		9/19 (47%)
		TM helix 6	264..294	CDD:320510	14/29 (48%)
		TM helix 7	304..326	CDD:320510	9/21 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..371		5/21 (24%)
CCAP-R	NP_001368957.1	7tmA_NPSR	124..416	CDD:320325	100/305 (33%)
		TM helix 1	126..150	CDD:320325	8/23 (35%)
		TM helix 2	159..182	CDD:320325	11/22 (50%)
		TM helix 3	197..219	CDD:320325	7/21 (33%)
		TM helix 4	240..256	CDD:320325	7/15 (47%)
		TM helix 5	282..305	CDD:320325	7/22 (32%)
		TM helix 6	348..370	CDD:320325	10/21 (48%)
		TM helix 7	384..409	CDD:320325	10/24 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6043
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3458
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.980