DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment AVPR2 and avpr2

DIOPT Version :9

Sequence 1:	NP_000045.1	Gene:	AVPR2 / 554	HGNCID:	897	Length:	371	Species:	Homo sapiens
Sequence 2:	XP_004916778.1	Gene:	avpr2 / 100487051	XenbaseID:	XB-GENE-482287	Length:	361	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	193/345 - (55%)
Similarity:	243/345 - (70%)	Gaps:	12/345 - (3%)

- Green bases have known domain annotations that are detailed below.

Human    30 DTRDPLLARAELALLSIVFVAVALSNGLVLAALARRGRRGHWAPIHVFIGHLCLADLAVALFQVL 94
            |.|||::|:..:|:|:::|......|.|||..|.|  ||.|.|.:|.|:.|||||||.|:.||||
Frog    20 DKRDPIVAQWNIAMLAVIFSFATFGNCLVLFTLLR--RRKHNALMHTFMIHLCLADLVVSFFQVL 82

Human    95 PQLAWKATDRFRGPDALCRAVKYLQMVGMYASSYMILAMTLDRHRAICRPMLAYRHGSGAHWNRP 159
            |||.|..||||||||.|||.|:|||:||||||||||:|||.|||:||||||:.::.|| |.||.|
Frog    83 PQLVWDITDRFRGPDVLCRGVRYLQVVGMYASSYMIVAMTFDRHQAICRPMMTFKKGS-ARWNIP 146

Human   160 VLVAWAFSLLLSLPQLFIFAQRNVEGGSGVTDCWACFAEPWGRRTYVTWIALMVFVAPTLGIAAC 224
            |.:||..|.:.||||.|||::  :|...||.||||.|.||||.:.|||||.|.||:.|.|.||.|
Frog   147 VSLAWLASAIFSLPQGFIFSR--IEVHPGVFDCWATFIEPWGLKAYVTWITLAVFILPALFIATC 209

Human   225 QVLIFREIHASLVPGPSERPGGRRRGR----RTGSPGEG-AHVSAAVAKTVRMTLVIVVVYVLCW 284
            |||||||||.|:..||...|..||:.:    |.|:..:. ..||:|:|||||||||||:|||:||
Frog   210 QVLIFREIHNSINMGPGHSPRPRRKAKLINTRNGARSQSDTGVSSAMAKTVRMTLVIVLVYVVCW 274

Human   285 APFFLVQLWAAWDPEAPLEGAPFVLLMLLASLNSCTNPWIYASFSSSVSSELRSLLCCA-RGRTP 348
            ||||:.|||..|:.|:....:...:||:|||||||||||||..||||||.:::.:||.| |.|..
Frog   275 APFFIAQLWNVWNQESAAGSSAIKVLMILASLNSCTNPWIYTIFSSSVSKDVKEILCFACRPRQR 339

Human   349 PSLGPQDESCTTASSSLAKD 368
            .:..|:| ||.|.|:::.|:
Frog   340 KNSLPED-SCFTGSTTVPKE 358

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
AVPR2	NP_000045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		193/345 (56%)
		7tmA_V2R	45..326	CDD:320510	167/285 (59%)
		TM helix 2	74..101	CDD:320510	18/26 (69%)
		TM helix 3	112..142	CDD:320510	23/29 (79%)
		TM helix 4	155..176	CDD:320510	11/20 (55%)
		TM helix 5	202..231	CDD:320510	18/28 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	240..259		6/22 (27%)
		TM helix 6	264..294	CDD:320510	23/29 (79%)
		TM helix 7	304..326	CDD:320510	14/21 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	349..371		7/20 (35%)
avpr2	XP_004916778.1	7tmA_V2R	31..325	CDD:320510	176/298 (59%)
		TM helix 1	31..55	CDD:320510	9/25 (36%)
		TM helix 2	62..89	CDD:320510	18/26 (69%)
		TM helix 3	100..130	CDD:320510	23/29 (79%)
		TM helix 4	142..163	CDD:320510	11/20 (55%)
		TM helix 5	187..216	CDD:320510	18/28 (64%)
		TM helix 6	254..284	CDD:320510	23/29 (79%)
		TM helix 7	294..319	CDD:320510	15/24 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	327	1.000	Domainoid score	I8233
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H20064
Inparanoid	1	1.050	371	1.000	Inparanoid score	I9524
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG40236
OrthoDB	1	1.010	-	-		D205853at32523
OrthoFinder	1	1.000	-	-		FOG0000774
OrthoInspector	1	1.000	-	-		oto155398
Panther	1	1.100	-	-	LDO	PTHR24241
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3458
SonicParanoid	1	1.000	-	-		X456
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	13	13.110