DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf130 and APE3

DIOPT Version :9

Sequence 1:	XP_009289393.1	Gene:	rnf130 / 553950	ZFINID:	ZDB-GENE-050522-525	Length:	428	Species:	Danio rerio
Sequence 2:	NP_009845.2	Gene:	APE3 / 852589	SGDID:	S000000490	Length:	537	Species:	Saccharomyces cerevisiae

Alignment Length:	207	Identity:	50/207 - (24%)
Similarity:	88/207 - (42%)	Gaps:	46/207 - (22%)

- Green bases have known domain annotations that are detailed below.

Zfish    30 SIGADKTMV-------NKEDYYSAIVNATVLDHKGNPQQMVTKN--DGRYGQNSPKTEAKGIVVA 85
            |.|.:|||.       :.:|||    :.::.:.:....::::.|  |...|::...|.|  ..::
Yeast   111 SKGHNKTMEYILNVFDDMQDYY----DVSLQEFEALSGKIISFNLSDAETGKSFANTTA--FALS 169

Zfish    86 PAA---VNGAVDLQGC-CPHTRF--IVPPK-TTHWVAIMQRGKCTFKEKILKAAAFNASAVIIYN 143
            |..   |...|::... |....:  :|||: ....:|:::||||.|.:|...|..|..:||:||:
Yeast   170 PPVDGFVGKLVEIPNLGCEEKDYASVVPPRHNEKQIALIERGKCPFGDKSNLAGKFGFTAVVIYD 234

Zfish   144 N--NTKEDTVTMAHEGTGDIVA-VMITESFGKEIL----------------GFLE--KNQTVLVS 187
            |  .:||.......|.|...|| |.:....||:::                .::|  |.|.::..
Yeast   235 NEPKSKEGLHGTLGEPTKHTVATVGVPYKVGKKLIANIALNIDYSLYFAMDSYVEFIKTQNIIAD 299

Zfish   188 VIVGSRGMPKNI 199
            .   ..|.|.||
Yeast   300 T---KHGDPDNI 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf130	XP_009289393.1	PA_GRAIL_like	49..188	CDD:239037	38/168 (23%)
rnf130	XP_009289393.1	zf-RING_2	271..314	CDD:290367
APE3	NP_009845.2	M28_SGAP_like	78..506	CDD:349873	50/207 (24%)
APE3	NP_009845.2	PA_ScAPY_like	155..284	CDD:239045	33/130 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910