DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf130 and Rnf130

DIOPT Version :9

Sequence 1:	XP_009289393.1	Gene:	rnf130 / 553950	ZFINID:	ZDB-GENE-050522-525	Length:	428	Species:	Danio rerio
Sequence 2:	NP_001277679.1	Gene:	Rnf130 / 59044	MGIID:	1891717	Length:	419	Species:	Mus musculus

Alignment Length:	426	Identity:	258/426 - (60%)
Similarity:	316/426 - (74%)	Gaps:	23/426 - (5%)

- Green bases have known domain annotations that are detailed below.

Zfish     6 AAPASCSSCLLALLLAFVSPRCSL-SIGADKTMVNKEDYYSAIVNATVLD-HKGNPQQMVTKND- 67
            |.||..::  ||||      .||| ...||..   .::||:|::|.||.: .:|.|  :..:.|
Mouse     7 AGPARLAA--LALL------TCSLWPTRADNA---SQEYYTALINVTVQEPGRGTP--LTFRIDR 58

Zfish    68 GRYGQNSPKTEAKGIVVAPAAVNGAVDLQGCCPHTRFIVPPKTTHWVAIMQRGKCTFKEKILKAA 132
            ||||.:|||.|.:|.|:||..::|..|..||.|.|||.|||....|:|::|||.|||||||.:||
Mouse    59 GRYGLDSPKAEVRGQVLAPLPIHGVADHLGCDPQTRFFVPPNIKQWIALLQRGNCTFKEKISRAA 123

Zfish   133 AFNASAVIIYNNNTKEDTVTMAHEGTGDIVAVMITESFGKEILGFLEKNQTVLVSVIVGSRGMPK 197
            ..||.||:||||.:||:.|||.|.|||||:||||||..||:||.:||||.:|.:::.||:|..||
Mouse   124 FHNAVAVVIYNNKSKEEPVTMTHPGTGDIIAVMITELRGKDILSYLEKNISVQMTIAVGTRMPPK 188

Zfish   198 NINRGSLVFVSISFIVLMIISSAWLIFYFIQKIRDTSARDRSQRRLGDAAKKAISKLTTRTVKRG 262
            |.:|||||||||||||||||||||||||||||||.|:||||:|||||||||||||||||||||:|
Mouse   189 NFSRGSLVFVSISFIVLMIISSAWLIFYFIQKIRYTNARDRNQRRLGDAAKKAISKLTTRTVKKG 253

Zfish   263 DKETEPDFNHCAVCIEGYQLNDVVRILPCKHVFHKMCVDPWLNEHCTCPMCKLNILKALGVMPNL 327
            ||||:|||:|||||||.|:.|||||:|||||||||.||||||:|||||||||||||||||::|||
Mouse   254 DKETDPDFDHCAVCIESYKQNDVVRVLPCKHVFHKSCVDPWLSEHCTCPMCKLNILKALGIVPNL 318

Zfish   328 PCVDNMAFDMDRMSRSQTSSQRTALVDLSSETSISLEPLRHSSSSQLPSDEELIPRSGEINIAVT 392
            ||.||:||||:|::|:|..::|.||.||:.::|:.|||||.|..|.||.|.||.||:||||||||
Mouse   319 PCTDNVAFDMERLTRTQAVNRRAALGDLAGDSSLGLEPLRTSGISPLPQDGELTPRTGEINIAVT 383

Zfish   393 KEWFIVASFGVLSALTLCYMIIRATASTTNYEPMLE 428
            ...  |.....||..:|.|     .:..:..||.|:
Mouse   384 SGH--VFHQNSLSPRSLVY-----ESEFSTIEPSLD 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf130	XP_009289393.1	PA_GRAIL_like	49..188	CDD:239037	77/140 (55%)
rnf130	XP_009289393.1	zf-RING_2	271..314	CDD:290367	35/42 (83%)
Rnf130	NP_001277679.1	PA_GRAIL_like	40..179	CDD:239037	77/140 (55%)
		HRD1	<197..>306	CDD:227568	96/108 (89%)
		RING-H2_RNF130	262..310	CDD:319717	40/47 (85%)
		RING-H2 finger (C3H2C3-type)	264..304	CDD:319717	33/39 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C193135324
Domainoid	1	1.000	153	1.000	Domainoid score	I17227
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41267
Inparanoid	1	1.050	490	1.000	Inparanoid score	I6570
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1487241at2759
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		oto55900
orthoMCL	1	0.900	-	-		OOG6_110755
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	14	14.400