DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rnf130 and H10E21.5

DIOPT Version :9

Sequence 1:	XP_009289393.1	Gene:	rnf130 / 553950	ZFINID:	ZDB-GENE-050522-525	Length:	428	Species:	Danio rerio
Sequence 2:	NP_497129.1	Gene:	H10E21.5 / 175169	WormBaseID:	WBGene00019185	Length:	473	Species:	Caenorhabditis elegans

Alignment Length:	189	Identity:	78/189 - (41%)
Similarity:	121/189 - (64%)	Gaps:	21/189 - (11%)

- Green bases have known domain annotations that are detailed below.

Zfish   197 KNINRGSLVFVSISFIVLMIISSAWLIFYFIQKIRDTSARDRSQRRLGDAAKKAISKLTTRTVKR 261
            ::.::.|::|||||||:||:||.|||:||::|:.|...|:||.||||.:||:||::::.|.|:..
Worm   153 RSFSKTSVLFVSISFIILMVISLAWLVFYYVQRFRYAHAKDRLQRRLFNAARKALTRIPTMTITP 217

Zfish   262 G-DKETEPDFNHCAVCIEGYQLNDVVRILPCKHVFHKMCVDPWLNEHCTCPMCKLNILKALGVMP 325
            | .:|.:.|   ||||::.|||.||:|:|||||::||.|:||||.||.||||||.:|||..|..
Worm   218 GMTQELQSD---CAVCLDPYQLQDVIRLLPCKHIYHKSCIDPWLLEHRTCPMCKNDILKHFGYW- 278

Zfish   326 NLPCVDNMAFDMDRMSRSQTSSQRTALVDLSSETSISLEPLRHSSSSQLPSDEELIPRS 384
                 :::..|:...:.|:         .::.:.:|.||  ......|.||.:.:.|.:
Worm   279 -----NDIRNDIQMPTNSR---------GIADDFTIRLE--LGEQEHQAPSADVISPEA 321

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rnf130	XP_009289393.1	PA_GRAIL_like	49..188	CDD:239037
rnf130	XP_009289393.1	zf-RING_2	271..314	CDD:290367	28/42 (67%)
H10E21.5	NP_497129.1	HRD1	<150..325	CDD:227568	78/189 (41%)
H10E21.5	NP_497129.1	RING-H2_GRAIL	226..273	CDD:319582	32/49 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5903
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000832
OrthoInspector	1	1.000	-	-		otm12529
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR22765
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X295
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.010