DRSC/TRiP Functional Genomics Resources

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Protein Alignment lrit1a and DIP-epsilon

DIOPT Version :9

Sequence 1:NP_001018174.2 Gene:lrit1a / 553943 ZFINID:ZDB-GENE-040924-5 Length:643 Species:Danio rerio
Sequence 2:NP_001137799.1 Gene:DIP-epsilon / 7354433 FlyBaseID:FBgn0259714 Length:467 Species:Drosophila melanogaster


Alignment Length:622 Identity:120/622 - (19%)
Similarity:186/622 - (29%) Gaps:226/622 - (36%)


- Green bases have known domain annotations that are detailed below.


Zfish     3 LTVFLGLLLASGGFPLVRSTCPTQCSCFYHNLSDGSRARSVICNDPEIS------LVPASFPGDT 61
            |.|.||.|:||.    |..:..|.......|:. ||...:||..|||.:      .|||   |..
  Fly    12 LYVGLGCLIASS----VALSTDTGSEGNAGNVG-GSTLNNVISEDPEFTDVIENITVPA---GRN 68

Zfish    62 SKLRIEKTAIKRIPSEAFSYLSNLEFLWMSFNVLSSLNSDSFRGLYSLEELRLDGNSLSSFPWES 126
            .||   ..::|.        |.:.:..||.|.                                 
  Fly    69 VKL---ACSVKN--------LGSYKVAWMHFE--------------------------------- 89

Zfish   127 LMDMPSLRLLDIHNNQLSSLPSEAALYMKNITYLDLSSNNLLTVPAEVLNTWLTIKPTLGAESSK 191
                 ...:|.:||:.::..|..:..:.|:..:                .||.            
  Fly    90 -----QSAILTVHNHVITRNPRISVTHDKHDKH----------------RTWF------------ 121

Zfish   192 LILGLHDN--------PWLCDCRL------YDLVQFQKSPSLSVAFIDTRLRCADPESLSGVLFS 242
                ||.|        .::|....      |..|:....|::..|...                |
  Fly   122 ----LHINNVQEEDRGRYMCQINTVTAKTQYGFVKVVVPPNIDDALTS----------------S 166

Zfish   243 DAELRRCQGPRVHTAVARVRSAVGNNVLLRCGTVGVPIPELAWRRADGKP--LNGTVLLENSKEG 305
            |..:|.                 |:||.|||...|.|.|.:.|:|.||..  :|.|:.:.:    
  Fly   167 DIIVRE-----------------GDNVTLRCKAKGSPEPTIKWKRDDGNKIVINKTLEVHD---- 210

Zfish   306 IVWSILSVPAVSYRDTGKYICKATN-YAGSAEAVISLIINDAPKMENP------------TLDPK 357
            :....|.:..:|....|.|:|.|:| ...|....|.:.::.:|.:..|            ||:  
  Fly   211 LETDSLELERISRLHMGAYLCIASNGVPPSVSKRIKVSVDFSPMVWIPHQLVGIPIGFNITLE-- 273

Zfish   358 PKLKSKKPNTMVKAAYQEKHIATYVSPTPKNGLPLSGTVSY-TGPYPGMESDNAANSRMNTQTAS 421
                          .:.|.:..:....|.:|...::.:..| |...||..|..|......|...|
  Fly   274 --------------CFIEANPTSLNYWTRENDQMITESSKYKTETIPGHPSYKATMRLTITNVQS 324

Zfish   422 PDGFLETNLSNLAANTSSLQQDPDRVVRSVKVIGDTDYTVCLNWRAP----------TAKNTTAF 476
            .|          ..|...:.::|.         ||.|..:.|...:|          |.:.||..
  Fly   325 SD----------YGNYKCVAKNPR---------GDMDGNIKLYMSSPPTTQPPPTTTTLRRTTTT 370

Zfish   477 SVLYAVFGERDMRRINVSPGNNRIVIEGLVPKTKYIAC--VCVKGL-----IPKKEQCVI----- 529
            :...|:.|     .||.....|.|.|.|..|....||.  ..:|.|     |.|.:|.:.     
  Fly   371 AAEIALDG-----YINTPLNGNGIGIVGEGPTNSVIASGKSSIKYLSNLNEIDKSKQKLTGSSPK 430

Zfish   530 -FSTDAAASANGTQKLINVVVITVACVIAVPLTVIVC 565
             |......|:.....|:......:.|::|: ||...|
  Fly   431 GFDWSKGKSSGSHGNLMASSWPLICCILAL-LTTHSC 466

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lrit1aNP_001018174.2 leucine-rich repeat 61..84 CDD:275378 4/22 (18%)
LRR_8 63..119 CDD:290566 7/55 (13%)
LRR_RI <77..175 CDD:238064 9/97 (9%)
leucine-rich repeat 85..108 CDD:275378 3/22 (14%)
LRR_8 108..167 CDD:290566 5/58 (9%)
leucine-rich repeat 109..132 CDD:275378 0/22 (0%)
leucine-rich repeat 133..156 CDD:275378 4/22 (18%)
leucine-rich repeat 157..170 CDD:275378 0/12 (0%)
LRRCT 199..243 CDD:214507 6/57 (11%)
I-set 252..343 CDD:254352 24/93 (26%)
Ig 259..333 CDD:299845 22/76 (29%)
fn3 448..515 CDD:278470 19/78 (24%)
DIP-epsilonNP_001137799.1 IG_like 59..155 CDD:214653 24/179 (13%)
Ig 69..139 CDD:143165 18/150 (12%)
IG_like 165..249 CDD:214653 27/120 (23%)
IGc2 172..237 CDD:197706 22/85 (26%)
IG_like 267..348 CDD:214653 19/115 (17%)
Ig 270..339 CDD:299845 16/103 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3510
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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