Protein Alignment TMCO6 and Pen

DIOPT Version :10

• Sequence 1: NP_001287909.1
• Gene: TMCO6 / 55374
• HGNCID: 28814
• Length: 499
• Species: Homo sapiens
• Sequence 2: NP_477041.1
• Gene: Pen / 34338
• FlyBaseID: FBgn0287720
• Length: 522
• Species: Drosophila melanogaster
• Alignment Length: 561
• Identity: 109/561 - (19%)
• Similarity: 216/561 - (38%)
• Gaps: 155/561 - (27%)

Human     5 RQGRLRPTVCGVEELRRRRREREAALRKARREQQLVSKRLLRND------------APEEAG-EG 56
            |||..:......::.|.||.|....|||:::|.|:..:|.:.::            :|.:.. :.
  Fly     9 RQGSYKANSINTQDSRMRRHEVTIELRKSKKEDQMFKRRNINDEDLTSPLKELNGQSPVQLSVDE 73

Human    57 CVAAILGETEVQQFL-RQAQRGTEEKEREGAL-VSLRRGLQHPETQQTFIRLEGSMRTLVGLLTS 119
            .|||:..|.:.:||| .|:.|....:||...: :.:..|:     ....||.         |..:
  Fly    74 IVAAMNSEDQERQFLGMQSARKMLSRERNPPIDLMIGHGI-----VPICIRF---------LQNT 124

Human   120 NQALLQLEAARCLHELSH--SEQSTVAEACL---PATSYLLTYLSSHSSDFIELCLYTLGNLIVE 179
            |.::||.|||..|..::.  |:|:    .|:   .|..:.:..|.|.|.:..|..::.|||:..:
  Fly   125 NNSMLQFEAAWALTNIASGTSDQT----RCVIEHNAVPHFVALLQSKSMNLAEQAVWALGNIAGD 185

Human   180 SEAVRRQLLPQGIVPALAACI--QSPHVAVLEALGYALSQLLQAE------EAPEKIIPPASASS 236
            ..|.|..::...::..:...|  ::| ::.|..:.:.:|.|.:.:      :..::::|
  Fly   186 GAAARDIVIHHNVIDGILPLINNETP-LSFLRNIVWLMSNLCRNKNPSPPFDQVKRLLP------ 243

Human   237 SILASTLPQHMLQMLQPGPKLNPGVAVEFAWCLHYIICSQVSN-PLLIGHGALSTLGLLLLDLAG 300
             :|:..|....:|:|           .:..|.|.|:.....:. ..::...|:..|..||
  Fly   244 -VLSQLLLSQDIQVL-----------ADACWALSYVTDDDNTKIQAVVDSDAVPRLVKLL----- 291

Human   301 AVQKTEDAGLELLACPVLRCLSNLLTEAAVETVGGQMQLRDERVVAA-----LFILLQFFFQKQP 360
              |..|.:    :..|.||.:.|::|....:|         :.|:|:     |.:|||   ..:.
  Fly   292 --QMDEPS----IIVPALRSVGNIVTGTDQQT---------DVVIASGGLPRLGLLLQ---HNKS 338

Human   361 SLLPEGLWLLNNLTANSPSFCTSLLSLDLIEPLLQLLPVSNVVSVMVLTVLCNVAEKGPAYCQR- 424
            :::.|..|.::|:||.:..                  .:..|:...:...|..|.|||....|:
  Fly   339 NIVKEAAWTVSNITAGNQK------------------QIQAVIQAGIFQQLRTVLEKGDFKAQKE 385

Human   425 -LWPGPLLPALLHTLAFSDTEVVGQSLE-------LLHLLFLYQPEAVQV--------------- 466
             .|      |:.:|......|.:...:|       .:.||....|..::|
  Fly   386 AAW------AVTNTTTSGTPEQIVDLIEKYKILKPFIDLLDTKDPRTIKVVQTGLSNLFALAEKL 444

Human   467 --------FLQQSG----LQALERHQEEAQLQDRVYALQQT 495
                    .:::.|    |:.|::|:.| ::..:.||:..|
  Fly   445 GGTENLCLMVEEMGGLDKLETLQQHENE-EVYKKAYAIIDT 484

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMCO6	NP_001287909.1	SRP1	23..>399	CDD:227396	80/409 (20%)
		armadillo repeat	104..135	CDD:293788	10/30 (33%)
		armadillo repeat	143..178	CDD:293788	9/37 (24%)
		armadillo repeat	184..218	CDD:293788	5/35 (14%)
Pen	NP_477041.1	SRP1	2..517	CDD:227396	109/561 (19%)
		HEAT repeat	70..102	CDD:293787	10/31 (32%)
		armadillo repeat	108..140	CDD:293788	11/45 (24%)
		armadillo repeat	148..184	CDD:293788	9/39 (23%)
		armadillo repeat	190..225	CDD:293788	5/35 (14%)
		armadillo repeat	359..396	CDD:293788	10/42 (24%)
		armadillo repeat	402..437	CDD:293788	5/34 (15%)