DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment PPP6C and PpV

DIOPT Version :9

Sequence 1:	NP_001116827.1	Gene:	PPP6C / 5537	HGNCID:	9323	Length:	342	Species:	Homo sapiens
Sequence 2:	NP_001259272.1	Gene:	PpV / 31582	FlyBaseID:	FBgn0003139	Length:	303	Species:	Drosophila melanogaster

Alignment Length:	338	Identity:	227/338 - (67%)
Similarity:	267/338 - (78%)	Gaps:	37/338 - (10%)

- Green bases have known domain annotations that are detailed below.

Human     5 DLDKYVEIARLCKYLPENDLKVSPICGLAPSGCGAPAGRPFLSPGPPPVFHFLRFLKERLCDYVC 69
            |:||::|..:.|||||||:||                                     :||:.||
  Fly     3 DVDKWIEDVKKCKYLPENELK-------------------------------------KLCEMVC 30

Human    70 DLLLEESNVQPVSTPVTVCGDIHGQFYDLCELFRTGGQVPDTNYIFMGDFVDRGYYSLETFTYLL 134
            |:||||:|:.|||||||||||||||||||.:|||||||||.|||||||||||||||||||||.||
  Fly    31 DILLEETNILPVSTPVTVCGDIHGQFYDLEQLFRTGGQVPHTNYIFMGDFVDRGYYSLETFTRLL 95

Human   135 ALKAKWPDRITLLRGNHESRQITQVYGFYDECQTKYGNANAWRYCTKVFDMLTVAALIDEQILCV 199
            .|||::|.||||||||||:||||:||||:|||.:||||||.|:||.||||:||:||:|||::|||
  Fly    96 TLKARYPSRITLLRGNHETRQITKVYGFFDECFSKYGNANGWKYCCKVFDLLTIAAIIDEEVLCV 160

Human   200 HGGLSPDIKTLDQIRTIERNQEIPHKGAFCDLVWSDPEDVDTWAISPRGAGWLFGAKVTNEFVHI 264
            ||||||:|.||||||||:||.|||:||||||||||||||::.|..||||||||||..||.:|:.|
  Fly   161 HGGLSPEIITLDQIRTIDRNGEIPYKGAFCDLVWSDPEDMEYWGQSPRGAGWLFGHNVTKDFMAI 225

Human   265 NNLKLICRAHQLVHEGYKFMFDEKLVTVWSAPNYCYRCGNIASIMVFKDVNTREPKLFRAVPDSE 329
            |||.|||||||||:||.|:|||.|||||||||||||||||:|:|:.|:....|:.|:|.||||:|
  Fly   226 NNLNLICRAHQLVNEGIKYMFDGKLVTVWSAPNYCYRCGNVAAILSFETAEKRQTKIFLAVPDAE 290

Human   330 RVIPPRTTTPYFL 342
            ||||.:.||||||
  Fly   291 RVIPKQNTTPYFL 303

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
PPP6C	NP_001116827.1	MPP_PP2A_PP4_PP6	5..326	CDD:277360	213/320 (67%)
PpV	NP_001259272.1	PTZ00239	3..303	CDD:173488	225/336 (67%)
PpV	NP_001259272.1	MPP_PP2A_PP4_PP6	3..287	CDD:277360	213/320 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159364
Domainoid	1	1.000	339	1.000	Domainoid score	I1102
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H68273
Inparanoid	1	1.050	501	1.000	Inparanoid score	I1371
Isobase	1	0.950	-	0	Normalized mean entropy	S176
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D349967at33208
OrthoFinder	1	1.000	-	-		FOG0000018
OrthoInspector	1	1.000	-	-		oto90193
orthoMCL	1	0.900	-	-		OOG6_103044
Panther	1	1.100	-	-	LDO	PTHR45619
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R960
SonicParanoid	1	1.000	-	-		X2805
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750