DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR4 and Lgr4

DIOPT Version :9

Sequence 1:NP_060960.2 Gene:LGR4 / 55366 HGNCID:13299 Length:951 Species:Homo sapiens
Sequence 2:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster


Alignment Length:846 Identity:190/846 - (22%)
Similarity:293/846 - (34%) Gaps:260/846 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIH 97
            |.|.|| .:.|..:.||.:||                 :||:..      |..|.|.||:...||
  Fly   162 CPCRGD-EILCRFQQLTDIPE-----------------RLPQHD------LATLDLTGNNFETIH 202

Human    98 PKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDD 162
            ....|.|.::..|.|:...::.:.|.|..        ||..|              .||.|::||
  Fly   203 ETFFSELPDVDSLVLKFCSIREIASHAFD--------RLADN--------------PLRTLYMDD 245

Human   163 NSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNL 227
            |.|..:|.|.......|..|.||.|.:..:....|.||..|..|.|..|:|.:.....|..|.||
  Fly   246 NKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNL 310

Human   228 ETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292
            |.|.||.|:             ||.|.         ||                           
  Fly   311 EVLYLNENH-------------LKRLD---------PD--------------------------- 326

Human   293 HNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
                              :||.....:|                          ||.|:||.|.|
  Fly   327 ------------------RFPRTLLNLH--------------------------TLSLAYNQIED 347

Human   358 LPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSF 422
                                  |...||. ...||.|.|:.|.:..|....|..|..:..|.::.
  Fly   348 ----------------------IAANTFP-FPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNE 389

Human   423 NELTSFPTEG---LNGLNQLKLVGN-FKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLN 483
            |.:..|..|.   |..|:.|.|.|| |:..::...|:..:|..:...:.:.|.|           
  Fly   390 NRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSA----------- 443

Human   484 TEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFI 548
                               |.||..             |.|.........:||.:.::|.:||.:
  Fly   444 -------------------AMNVRV-------------CDPHGDGISSKLHLLDNQILRGSVWVM 476

Human   549 FLVALFFNLLVIL-TTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWW 612
            ..:|:..||||:| ..|....|.....|::..::.|:..||||..::...|....|.:.::...|
  Fly   477 ASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETW 541

Human   613 ETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFL-----G 672
            .....|..||||:.||.:|:..||.|.|.:|.:|   :.:..|....::.|:...|..|     |
  Fly   542 RHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMS---VTRPLKPRDTEKVRIVLRLLLLWGISFG 603

Human   673 ATVAGCFPLFHRGE--YSASPLCL------PFPTG-ETPSLGFTVTLVLLNSLAFLLMAVIYTKL 728
            ...|...|..:.|.  |..:.:||      |:..| |..:|.|    :|:|:|:.:.:...|.::
  Fly   604 LAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLF----ILVNTLSLIFILFSYIRM 664

Human   729 YCNLEKEDLSENSQSSMIKHV-----AWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLI 788
            ...:........|..|..::|     |.::.|:|..:.|:.....|.| :...|||::...:.::
  Fly   665 LQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAAL-SGCEISPDLYAWLAVL 728

Human   789 FFPLPACLNPVLYVFFNPKFKEDWKLLKR-------------------RVTKKSGSVSVSISSQG 834
            ..|:.:.||||||......||:.   |:|                   :...:|| :|||::..|
  Fly   729 VLPVNSALNPVLYTLTTAAFKQQ---LRRYCHTLPSCSLVNNETRSQTQTAYESG-LSVSLAHLG 789

Human   835 G 835
            |
  Fly   790 G 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR4NP_060960.2 LRRNT 29..56 CDD:279764 9/22 (41%)
LRR_RI <44..239 CDD:238064 53/194 (27%)
LRR 1 58..79 2/20 (10%)
leucine-rich repeat 59..82 CDD:275380 2/22 (9%)
LRR 2 82..103 7/20 (35%)
LRR_8 83..141 CDD:290566 16/57 (28%)
leucine-rich repeat 83..106 CDD:275380 9/22 (41%)
LRR 3 106..127 4/20 (20%)
leucine-rich repeat 107..130 CDD:275380 4/22 (18%)
LRR 4 130..151 3/20 (15%)
LRR_8 131..189 CDD:290566 17/57 (30%)
leucine-rich repeat 131..154 CDD:275380 3/22 (14%)
LRR 5 154..177 9/22 (41%)
leucine-rich repeat 155..178 CDD:275380 9/22 (41%)
LRR_8 177..237 CDD:290566 22/59 (37%)
LRR 6 178..199 6/20 (30%)
leucine-rich repeat 179..202 CDD:275380 8/22 (36%)
LRR 7 202..223 6/20 (30%)
leucine-rich repeat 203..226 CDD:275380 7/22 (32%)
LRR_RI 221..426 CDD:238064 37/204 (18%)
LRR 8 226..247 7/20 (35%)
leucine-rich repeat 227..249 CDD:275380 6/21 (29%)
LRR_8 248..305 CDD:290566 5/56 (9%)
LRR 9 249..270 5/20 (25%)
leucine-rich repeat 250..273 CDD:275380 5/22 (23%)
LRR 10 273..294 0/20 (0%)
leucine-rich repeat 274..295 CDD:275380 0/20 (0%)
LRR 11 320..341 1/20 (5%)
LRR 12 344..365 7/20 (35%)
LRR_8 345..401 CDD:290566 15/55 (27%)
leucine-rich repeat 345..366 CDD:275380 7/20 (35%)
LRR 13 366..387 3/20 (15%)
leucine-rich repeat 367..390 CDD:275380 3/22 (14%)
LRR_8 390..444 CDD:290566 16/56 (29%)
LRR 14 390..411 7/20 (35%)
leucine-rich repeat 391..414 CDD:275380 8/22 (36%)
LRR 15 414..435 5/23 (22%)
leucine-rich repeat 415..438 CDD:275380 6/25 (24%)
leucine-rich repeat 439..461 CDD:275380 7/22 (32%)
7tm_1 556..801 CDD:278431 67/264 (25%)
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:278486
LRR_RI <184..397 CDD:238064 77/356 (22%)
LRR_8 188..248 CDD:290566 22/81 (27%)
leucine-rich repeat 188..211 CDD:275380 9/22 (41%)
leucine-rich repeat 212..235 CDD:275380 6/30 (20%)
leucine-rich repeat 238..261 CDD:275380 9/22 (41%)
LRR_8 261..320 CDD:290566 22/71 (31%)
leucine-rich repeat 262..285 CDD:275380 8/22 (36%)
LRR_4 284..325 CDD:289563 17/62 (27%)
leucine-rich repeat 286..309 CDD:275380 7/22 (32%)
LRR_4 308..348 CDD:289563 22/154 (14%)
leucine-rich repeat 310..334 CDD:275380 13/90 (14%)
leucine-rich repeat 335..357 CDD:275380 11/70 (16%)
LRR_8 356..416 CDD:290566 18/59 (31%)
leucine-rich repeat 358..381 CDD:275380 8/22 (36%)
LRR_4 381..421 CDD:289563 11/39 (28%)
leucine-rich repeat 382..405 CDD:275380 5/22 (23%)
leucine-rich repeat 406..427 CDD:275380 7/20 (35%)
7tm_1 483..741 CDD:278431 67/265 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2087
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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