DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR4 and Lgr4

DIOPT Version :10

Sequence 1:NP_060960.2 Gene:LGR4 / 55366 HGNCID:13299 Length:951 Species:Homo sapiens
Sequence 2:NP_001285192.1 Gene:Lgr4 / 5740505 FlyBaseID:FBgn0085440 Length:809 Species:Drosophila melanogaster


Alignment Length:846 Identity:190/846 - (22%)
Similarity:293/846 - (34%) Gaps:260/846 - (30%)


- Green bases have known domain annotations that are detailed below.


Human    33 CSCDGDRRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIH 97
            |.|.|| .:.|..:.||.:||                 :||:..      |..|.|.||:...||
  Fly   162 CPCRGD-EILCRFQQLTDIPE-----------------RLPQHD------LATLDLTGNNFETIH 202

Human    98 PKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDD 162
            ....|.|.::..|.|:...::.:.|.|..        ||..|              .||.|::||
  Fly   203 ETFFSELPDVDSLVLKFCSIREIASHAFD--------RLADN--------------PLRTLYMDD 245

Human   163 NSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNL 227
            |.|..:|.|.......|..|.||.|.:..:....|.||..|..|.|..|:|.:.....|..|.||
  Fly   246 NKLPHLPEHFFPEGNQLSILILARNHLHHLKRSDFLNLQKLQELDLRGNRIGNFEAEVFARLPNL 310

Human   228 ETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAF 292
            |.|.||.|:             ||.|.         ||                           
  Fly   311 EVLYLNENH-------------LKRLD---------PD--------------------------- 326

Human   293 HNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRD 357
                              :||.....:|                          ||.|:||.|.|
  Fly   327 ------------------RFPRTLLNLH--------------------------TLSLAYNQIED 347

Human   358 LPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLDVSF 422
                                  |...||. ...||.|.|:.|.:..|....|..|..:..|.::.
  Fly   348 ----------------------IAANTFP-FPRLRYLFLAGNRLSHIRDETFCNLSNLQGLHLNE 389

Human   423 NELTSFPTEG---LNGLNQLKLVGN-FKLKEALAAKDFVNLRSLSVPYAYQCCAFWGCDSYANLN 483
            |.:..|..|.   |..|:.|.|.|| |:..::...|:..:|..:...:.:.|.|           
  Fly   390 NRIEGFDLEAFACLKNLSSLLLTGNRFQTLDSRVLKNLTSLDYIYFSWFHLCSA----------- 443

Human   484 TEDNSLQDHSVAQEKGTADAANVTSTLENEEHSQIIIHCTPSTGAFKPCEYLLGSWMIRLTVWFI 548
                               |.||..             |.|.........:||.:.::|.:||.:
  Fly   444 -------------------AMNVRV-------------CDPHGDGISSKLHLLDNQILRGSVWVM 476

Human   549 FLVALFFNLLVIL-TTFASCTSLPSSKLFIGLISVSNLFMGIYTGILTFLDAVSWGRFAEFGIWW 612
            ..:|:..||||:| ..|....|.....|::..::.|:..||||..::...|....|.:.::...|
  Fly   477 ASIAVVGNLLVLLGRYFYKSRSNVEHSLYLRHLAASDFLMGIYLTLIACADISFRGEYIKYEETW 541

Human   613 ETGSGCKVAGFLAVFSSESAIFLLMLATVERSLSAKDIMKNGKSNHLKQFRVAALLAFL-----G 672
            .....|..||||:.||.:|:..||.|.|.:|.:|   :.:..|....::.|:...|..|     |
  Fly   542 RHSGVCAFAGFLSTFSCQSSTLLLTLVTWDRLMS---VTRPLKPRDTEKVRIVLRLLLLWGISFG 603

Human   673 ATVAGCFPLFHRGE--YSASPLCL------PFPTG-ETPSLGFTVTLVLLNSLAFLLMAVIYTKL 728
            ...|...|..:.|.  |..:.:||      |:..| |..:|.|    :|:|:|:.:.:...|.::
  Fly   604 LAAAPLLPNPYFGSHFYGNNGVCLSLHIHDPYAKGWEYSALLF----ILVNTLSLIFILFSYIRM 664

Human   729 YCNLEKEDLSENSQSSMIKHV-----AWLIFTNCIFFCPVAFFSFAPLITAISISPEIMKSVTLI 788
            ...:........|..|..::|     |.::.|:|..:.|:.....|.| :...|||::...:.::
  Fly   665 LQAIRDSGGGMRSTHSGRENVVATRFAIIVTTDCACWLPIIVVKLAAL-SGCEISPDLYAWLAVL 728

Human   789 FFPLPACLNPVLYVFFNPKFKEDWKLLKR-------------------RVTKKSGSVSVSISSQG 834
            ..|:.:.||||||......||:.   |:|                   :...:|| :|||::..|
  Fly   729 VLPVNSALNPVLYTLTTAAFKQQ---LRRYCHTLPSCSLVNNETRSQTQTAYESG-LSVSLAHLG 789

Human   835 G 835
            |
  Fly   790 G 790

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR4NP_060960.2 PLN00113 34..>443 CDD:215061 91/411 (22%)
LRR 1 58..79 2/20 (10%)
leucine-rich repeat 59..82 CDD:275380 2/22 (9%)
LRR <75..>261 CDD:443914 50/185 (27%)
LRR 2 82..103 7/20 (35%)
leucine-rich repeat 83..106 CDD:275380 9/22 (41%)
LRR 3 106..127 4/20 (20%)
leucine-rich repeat 107..130 CDD:275380 4/22 (18%)
LRR 4 130..151 3/20 (15%)
leucine-rich repeat 131..154 CDD:275380 3/22 (14%)
LRR 5 154..177 9/22 (41%)
leucine-rich repeat 155..178 CDD:275380 9/22 (41%)
LRR 6 178..199 6/20 (30%)
leucine-rich repeat 179..202 CDD:275380 8/22 (36%)
LRR 7 202..223 6/20 (30%)
leucine-rich repeat 203..226 CDD:275380 7/22 (32%)
LRR 8 226..247 7/20 (35%)
leucine-rich repeat 227..249 CDD:275380 6/21 (29%)
LRR 9 249..270 5/20 (25%)
leucine-rich repeat 250..273 CDD:275380 5/22 (23%)
LRR 10 273..294 0/20 (0%)
leucine-rich repeat 274..295 CDD:275380 0/20 (0%)
LRR 11 320..341 1/20 (5%)
LRR 12 344..365 7/20 (35%)
leucine-rich repeat 345..366 CDD:275380 7/20 (35%)
LRR 13 366..387 3/20 (15%)
leucine-rich repeat 367..390 CDD:275380 3/22 (14%)
LRR 14 390..411 7/20 (35%)
leucine-rich repeat 391..414 CDD:275380 8/22 (36%)
LRR 15 414..435 5/23 (22%)
leucine-rich repeat 415..438 CDD:275380 6/25 (24%)
leucine-rich repeat 439..461 CDD:275380 7/22 (32%)
7tmA_LGR4 539..812 CDD:320483 75/292 (26%)
TM helix 1 540..566 CDD:320483 10/26 (38%)
TM helix 2 573..598 CDD:320483 6/24 (25%)
TM helix 3 618..648 CDD:320483 14/29 (48%)
TM helix 4 660..682 CDD:320483 6/26 (23%)
TM helix 5 702..731 CDD:320483 6/28 (21%)
TM helix 6 740..770 CDD:320483 7/34 (21%)
TM helix 7 780..805 CDD:320483 7/24 (29%)
Lgr4NP_001285192.1 Ldl_recept_a 87..124 CDD:395011
LRR 167..>430 CDD:443914 93/424 (22%)
leucine-rich repeat 188..211 CDD:275380 9/22 (41%)
leucine-rich repeat 212..235 CDD:275380 6/30 (20%)
leucine-rich repeat 238..261 CDD:275380 9/22 (41%)
leucine-rich repeat 262..285 CDD:275380 8/22 (36%)
leucine-rich repeat 286..309 CDD:275380 7/22 (32%)
leucine-rich repeat 310..334 CDD:275380 13/90 (14%)
leucine-rich repeat 335..357 CDD:275380 11/70 (16%)
leucine-rich repeat 358..381 CDD:275380 8/22 (36%)
leucine-rich repeat 382..405 CDD:275380 5/22 (23%)
leucine-rich repeat 406..427 CDD:275380 7/20 (35%)
7tmA_Relaxin_R 467..752 CDD:320265 75/295 (25%)
TM helix 1 468..494 CDD:320265 9/25 (36%)
TM helix 2 502..527 CDD:320265 6/24 (25%)
TM helix 3 547..577 CDD:320265 14/32 (44%)
TM helix 4 588..610 CDD:320265 5/21 (24%)
TM helix 5 638..667 CDD:320265 8/32 (25%)
TM helix 6 681..711 CDD:320265 5/29 (17%)
TM helix 7 720..745 CDD:320265 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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