DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LGR4 and Lrt

DIOPT Version :10

Sequence 1:NP_060960.2 Gene:LGR4 / 55366 HGNCID:13299 Length:951 Species:Homo sapiens
Sequence 2:NP_001286640.1 Gene:Lrt / 37342 FlyBaseID:FBgn0034540 Length:830 Species:Drosophila melanogaster


Alignment Length:591 Identity:146/591 - (24%)
Similarity:228/591 - (38%) Gaps:152/591 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    33 CSCDGDRRVDCS----GKGLTAVPEGLSAFT-QALDISMNNITQLPEDAFKNFPFLEELQLAGND 92
            |.||....:.|:    |..|.|.....|.:: ..||.|:.|:|           ||.:.::..| 
  Fly   145 CGCDLPHTLRCNIDLHGMMLLADRLRTSPYSISLLDCSLRNVT-----------FLSDAKIFDN- 197

Human    93 LSFIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGL-SALQSLRLDANHITSVPEDSFEGLVQLR 156
                  .:|.|      |.:.:.::|.|...|..|: ..||:|.|..|.:.|||           
  Fly   198 ------VSLHG------LVISSGEIKRVHKSAFLGIRGPLQALGLPGNALMSVP----------- 239

Human   157 HLWLDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCF 221
              |           :.||.|..|:.|.||.|||.::....|..|:|||.|.|.||:|.|:||..|
  Fly   240 --W-----------NALSTLSALERLDLANNKIKALGTADFVGLTSLVYLELSNNQISSISQRTF 291

Human   222 DGLDNLETLDLNYNNLGEFPQAIKALP---SLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNP 283
            ..|..||.|.|..|.||::.|::::|.   ||::|...:|::                    :.|
  Fly   292 VNLRKLEVLKLGGNRLGDYAQSLRSLSQCLSLRQLDLQANNL--------------------NGP 336

Human   284 LSFVGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTL 348
            ||                        :|  .|.|..:||||.|....|.||.|........|.:|
  Fly   337 LS------------------------EQ--TLPGMRNLESLNLNRNLIKSIQNKALANFSRLVSL 375

Human   349 DLSYNNIRDLP--SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
            .|.:|.|..|.  :|.|..||:.:.|..|.|..|...:.|.|..|.:|||:.|.:..:.|...|.
  Fly   376 SLRHNQIDVLQDHAFFGLGALDSLDLSYNGIVAISSASLQHLSRLTVLDLTHNFLRALTSDLIAP 440

Human   412 LGPITNLDVSFNELTSFPTEGLNG---LNQLKLVGN-----------------FKLKEALAAKDF 456
            |..:..|.::.|:::......::|   |..|::..|                 .:|..:|:|...
  Fly   441 LPSLRELRLAGNDISIVARNAMDGARELESLQMQENPLSCDCSIRPFAEWLQESQLHSSLSASCV 505

Human   457 VNLRSLSVPYAYQCCAFWGCDSYANLNTEDNSLQDH-SVAQEKGTADAANVTSTLENEEHSQII- 519
            ...|....|..........||.       ||..:|: ::.|...|....|.||.:::.....|: 
  Fly   506 TPPRLEGAPLLQVPVETLSCDM-------DNVEKDNANIMQHLETLAKPNQTSPIKDLSEEIILH 563

Human   520 -IHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALF------FNLLVILTTFASCTSLPSSKLFI 577
             :|.:...|       |:.:|::.|:.......|:|      .|.::|..:...|    .||:..
  Fly   564 ELHFSTDYG-------LILTWLLNLSKKDYMCDAIFVYKEEHINEILIDNSPIHC----ESKVVN 617

Human   578 GLISVS 583
            |..:||
  Fly   618 GQNTVS 623

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR4NP_060960.2 PLN00113 34..>443 CDD:215061 113/422 (27%)
LRR 1 58..79 5/21 (24%)
leucine-rich repeat 59..82 CDD:275380 5/23 (22%)
LRR <75..>261 CDD:443914 57/189 (30%)
LRR 2 82..103 4/20 (20%)
leucine-rich repeat 83..106 CDD:275380 4/22 (18%)
LRR 3 106..127 4/20 (20%)
leucine-rich repeat 107..130 CDD:275380 5/23 (22%)
LRR 4 130..151 8/20 (40%)
leucine-rich repeat 131..154 CDD:275380 8/22 (36%)
LRR 5 154..177 3/22 (14%)
leucine-rich repeat 155..178 CDD:275380 4/22 (18%)
LRR 6 178..199 8/20 (40%)
leucine-rich repeat 179..202 CDD:275380 9/22 (41%)
LRR 7 202..223 12/20 (60%)
leucine-rich repeat 203..226 CDD:275380 12/22 (55%)
LRR 8 226..247 8/20 (40%)
leucine-rich repeat 227..249 CDD:275380 9/24 (38%)
LRR 9 249..270 4/20 (20%)
leucine-rich repeat 250..273 CDD:275380 3/22 (14%)
LRR 10 273..294 3/20 (15%)
leucine-rich repeat 274..295 CDD:275380 3/20 (15%)
LRR 11 320..341 9/20 (45%)
LRR 12 344..365 8/22 (36%)
leucine-rich repeat 345..366 CDD:275380 8/22 (36%)
LRR 13 366..387 6/20 (30%)
leucine-rich repeat 367..390 CDD:275380 7/22 (32%)
LRR 14 390..411 6/20 (30%)
leucine-rich repeat 391..414 CDD:275380 8/22 (36%)
LRR 15 414..435 2/20 (10%)
leucine-rich repeat 415..438 CDD:275380 4/25 (16%)
leucine-rich repeat 439..461 CDD:275380 5/38 (13%)
7tmA_LGR4 539..812 CDD:320483 12/51 (24%)
TM helix 1 540..566 CDD:320483 5/31 (16%)
TM helix 2 573..598 CDD:320483 5/11 (45%)
TM helix 3 618..648 CDD:320483
TM helix 4 660..682 CDD:320483
TM helix 5 702..731 CDD:320483
TM helix 6 740..770 CDD:320483
TM helix 7 780..805 CDD:320483
LrtNP_001286640.1 LRR 175..582 CDD:443914 127/514 (25%)
leucine-rich repeat 179..199 CDD:275378 8/37 (22%)
leucine-rich repeat 200..223 CDD:275380 7/28 (25%)
leucine-rich repeat 225..248 CDD:275380 12/46 (26%)
leucine-rich repeat 249..272 CDD:275380 9/22 (41%)
leucine-rich repeat 273..296 CDD:275380 12/22 (55%)
leucine-rich repeat 297..322 CDD:275380 9/24 (38%)
leucine-rich repeat 323..347 CDD:275380 9/69 (13%)
leucine-rich repeat 348..371 CDD:275380 9/22 (41%)
leucine-rich repeat 372..395 CDD:275380 8/22 (36%)
leucine-rich repeat 396..419 CDD:275380 7/22 (32%)
leucine-rich repeat 420..443 CDD:275380 8/22 (36%)
leucine-rich repeat 444..467 CDD:275380 3/22 (14%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.