DRSC/TRiP Functional Genomics Resources

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Protein Alignment LGR4 and rk

DIOPT Version :10

Sequence 1:NP_060960.2 Gene:LGR4 / 55366 HGNCID:13299 Length:951 Species:Homo sapiens
Sequence 2:NP_476702.1 Gene:rk / 34819 FlyBaseID:FBgn0003255 Length:1360 Species:Drosophila melanogaster


Alignment Length:881 Identity:265/881 - (30%)
Similarity:414/881 - (46%) Gaps:107/881 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    33 CSCDGD---RRVDCSGKGLTAVPEGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLS 94
            |.|.|.   .|:.|.|.|:.|||..|......||:..||:|:|..::|...|.||||.|:.|.:.
  Fly   152 CHCTGSLEVLRLSCRGIGILAVPVNLPNEVVVLDLGNNNLTKLEANSFFMAPNLEELTLSDNSII 216

Human    95 FIHPKALSGLKELKVLTLQNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLW 159
            .:.|.|..||.:||.|:|||..||::|.::.:||:.|.||:|:.|.:.|:..|....|.:||.|.
  Fly   217 NMDPNAFYGLAKLKRLSLQNCGLKSLPPQSFQGLAQLTSLQLNGNALVSLDGDCLGHLQKLRTLR 281

Human   160 LDDNSLTEVPVHPLSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGL 224
            |:.|....:|.:.|:.|.||:||.|..|.::.|.|..|..:.:|:||.|..|:|..:|......|
  Fly   282 LEGNLFYRIPTNALAGLRTLEALNLGSNLLTIINDEDFPRMPNLIVLLLKRNQIMKISAGALKNL 346

Human   225 DNLETLDLNYNNLGEFPQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYD---NPLSF 286
            ..|:.|:|:.|.:...|:.:..|..|:||...||.:..|.|     ..|.|::.:.|   ||||.
  Fly   347 TALKVLELDDNLISSLPEGLSKLSQLQELSITSNRLRWIND-----TELPRSMQMLDMRANPLST 406

Human   287 VGNSAFHNLSDLHSLVIRGASMVQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLS 351
            :...||..:|.|..|::.....::.||.|.....||.|.|....|..:|.|||::...|::|:|.
  Fly   407 ISPGAFRGMSKLRKLILSDVRTLRSFPELEACHALEILKLDRAGIQEVPANLCRQTPRLKSLELK 471

Human   352 YNNIRDLPSFNGCHALEEISLQRNQIYQIK------------------------EGTFQGLISLR 392
            .|:::.:|:.:.|..|..:.|..|||.:|:                        :..|||:..|:
  Fly   472 TNSLKRIPNLSSCRDLRLLDLSSNQIEKIQGKPFNGLKQLNDLLLSYNRIKALPQDAFQGIPKLQ 536

Human   393 ILDLSRNLIHEIHSRAFATLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGNFKLKEALAAKDFV 457
            :|||..|.|..||..||:....:.:|::..|.....|..||..|..||...|.||:|......|.
  Fly   537 LLDLEGNEISYIHKEAFSGFTALEDLNLGNNIFPELPESGLRALLHLKTFNNPKLREFPPPDTFP 601

Human   458 NLRSLSVPYAYQCCAF--------------------WGCDSYANLNTEDNSL-----QDHSVAQE 497
            .:::|.:.|||.||||                    :..|:..::...:||:     |.|:::::
  Fly   602 RIQTLILSYAYHCCAFLPLVAMSSQKKTSQVQEAVLFPSDAEFDMTLWNNSMMNIWPQMHNLSKQ 666

Human   498 KGTA------DAAN--------------VTSTLEN--EEHSQI---------------------- 518
            .|.:      .|.|              .||.:|.  |||...                      
  Fly   667 LGASMHDPWETAINFNEEQLQTQTGGQIATSYMEEYFEEHDVSGPATGYGFGTGLFSGMSTEDFQ 731

Human   519 --IIHCTPSTGAFKPCEYLLGSWMIRLTVWFIFLVALFFNLLVILTTFASCTSLPSSKLFIGLIS 581
              .:.|.|..|.|.||..|...|.:|..||.:||::|..|..|:.....|.:.:...:..:..::
  Fly   732 PGSVQCLPMPGPFLPCADLFDWWTLRCGVWVVFLLSLLGNGTVVFVLLCSRSKMDVPRFLVCNLA 796

Human   582 VSNLFMGIYTGILTFLDAVSWGRFAEFGIWWETGSGCKVAGFLAVFSSESAIFLLMLATVERSLS 646
            .::.|||||.|||..:||.:.|.|..|.|.|:....|:::|||||.|||.:::.|.:.|:||:.:
  Fly   797 AADFFMGIYLGILAIVDAATLGEFRMFAIPWQMSVLCQLSGFLAVLSSELSVYTLAVITLERNYA 861

Human   647 AKDIMKNGKSNHLKQFRVAALLAFLGATVAGCFPLFHRGEYSASPLCLPFPTGETP-SLGFTVTL 710
            ....:...|...|||......:.::.|.:....||....:|....:||||.|...| ||.:.::|
  Fly   862 ITHAIHLNKRLSLKQAGYIMSVGWVFALIMALMPLVGVSDYRKFAVCLPFETTTGPASLTYVISL 926

Human   711 VLLNSLAFLLMAVIYTKLYCNLEKEDLSENSQSSMIKHVAWLIFTNCIFFCPVAFFSFAPLITAI 775
            :.:|..|||.:...|.|:|..:........:.|.:.|.:|.|:||:.:.:.|:||||...:....
  Fly   927 MFINGCAFLTLMGCYLKMYWAIRGSQAWNTNDSRIAKRMALLVFTDFLCWSPIAFFSITAIFGLQ 991

Human   776 SISPEIMKSVTLIFFPLPACLNPVLYVFFNPKFKED 811
            .||.|..|..|:...||.:|.||.||.....:||:|
  Fly   992 LISLEQAKIFTVFVLPLNSCCNPFLYAIMTKQFKKD 1027

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LGR4NP_060960.2 PLN00113 34..>443 CDD:215061 142/438 (32%)
LRR 1 58..79 7/20 (35%)
leucine-rich repeat 59..82 CDD:275380 7/22 (32%)
LRR <75..>261 CDD:443914 67/185 (36%)
LRR 2 82..103 8/20 (40%)
leucine-rich repeat 83..106 CDD:275380 10/22 (45%)
LRR 3 106..127 9/20 (45%)
leucine-rich repeat 107..130 CDD:275380 11/22 (50%)
LRR 4 130..151 7/20 (35%)
leucine-rich repeat 131..154 CDD:275380 8/22 (36%)
LRR 5 154..177 7/22 (32%)
leucine-rich repeat 155..178 CDD:275380 8/22 (36%)
LRR 6 178..199 9/20 (45%)
leucine-rich repeat 179..202 CDD:275380 8/22 (36%)
LRR 7 202..223 7/20 (35%)
leucine-rich repeat 203..226 CDD:275380 8/22 (36%)
LRR 8 226..247 5/20 (25%)
leucine-rich repeat 227..249 CDD:275380 6/21 (29%)
LRR 9 249..270 7/20 (35%)
leucine-rich repeat 250..273 CDD:275380 7/22 (32%)
LRR 10 273..294 9/23 (39%)
leucine-rich repeat 274..295 CDD:275380 8/23 (35%)
LRR 11 320..341 9/20 (45%)
LRR 12 344..365 5/20 (25%)
leucine-rich repeat 345..366 CDD:275380 6/20 (30%)
LRR 13 366..387 7/44 (16%)
leucine-rich repeat 367..390 CDD:275380 9/46 (20%)
LRR 14 390..411 10/20 (50%)
leucine-rich repeat 391..414 CDD:275380 10/22 (45%)
LRR 15 414..435 5/20 (25%)
leucine-rich repeat 415..438 CDD:275380 6/22 (27%)
leucine-rich repeat 439..461 CDD:275380 7/21 (33%)
7tmA_LGR4 539..812 CDD:320483 88/274 (32%)
TM helix 1 540..566 CDD:320483 8/25 (32%)
TM helix 2 573..598 CDD:320483 8/24 (33%)
TM helix 3 618..648 CDD:320483 13/29 (45%)
TM helix 4 660..682 CDD:320483 4/21 (19%)
TM helix 5 702..731 CDD:320483 11/29 (38%)
TM helix 6 740..770 CDD:320483 11/29 (38%)
TM helix 7 780..805 CDD:320483 10/24 (42%)
rkNP_476702.1 LRR <157..390 CDD:443914 83/237 (35%)
leucine-rich repeat 158..179 CDD:275380 8/20 (40%)
leucine-rich repeat 183..204 CDD:275380 7/20 (35%)
leucine-rich repeat 205..228 CDD:275380 10/22 (45%)
leucine-rich repeat 229..252 CDD:275380 11/22 (50%)
leucine-rich repeat 253..276 CDD:275380 8/22 (36%)
leucine-rich repeat 277..300 CDD:275380 8/22 (36%)
LRR 292..612 CDD:443914 96/324 (30%)
leucine-rich repeat 301..324 CDD:275380 8/22 (36%)
leucine-rich repeat 325..348 CDD:275380 8/22 (36%)
leucine-rich repeat 349..371 CDD:275380 6/21 (29%)
leucine-rich repeat 372..393 CDD:275380 8/25 (32%)
leucine-rich repeat 394..415 CDD:275380 7/20 (35%)
leucine-rich repeat 418..486 CDD:275380 20/67 (30%)
leucine-rich repeat 441..464 CDD:275378 9/22 (41%)
leucine-rich repeat 487..510 CDD:275380 6/22 (27%)
leucine-rich repeat 511..534 CDD:275380 3/22 (14%)
leucine-rich repeat 535..558 CDD:275380 10/22 (45%)
leucine-rich repeat 559..580 CDD:275380 5/20 (25%)
7tmA_Glyco_hormone_R 754..1028 CDD:320264 88/274 (32%)
TM helix 1 755..781 CDD:320264 8/25 (32%)
TM helix 2 788..813 CDD:320264 8/24 (33%)
TM helix 3 833..863 CDD:320264 13/29 (45%)
TM helix 4 875..897 CDD:320264 4/21 (19%)
TM helix 5 918..947 CDD:320264 10/28 (36%)
TM helix 6 956..986 CDD:320264 11/29 (38%)
TM helix 7 996..1021 CDD:320264 10/24 (42%)

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