Protein Alignment TMEM63B and Tmem63b

DIOPT Version :10

• Sequence 1: XP_016866488.1
• Gene: TMEM63B / 55362
• HGNCID: 17735
• Length: 841
• Species: Homo sapiens
• Sequence 2: NP_937810.2
• Gene: Tmem63b / 224807
• MGIID: 2387609
• Length: 832
• Species: Mus musculus
• Alignment Length: 832
• Identity: 817/832 - (98%)
• Similarity: 823/832 - (98%)
• Gaps: 0/832 - (0%)

Human    10 MLPFLLATLGTTALNNSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKV 74
            |||||||||||.|||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse     1 MLPFLLATLGTAALNSSNPKDYCYSARIRSTVLQGLPFGGVPTVLALDFMCFLALLFLFSILRKV 65

Human    75 AWDYGRLALVTDADRLRRQERDRVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLT 139
            |||||||||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||
Mouse    66 AWDYGRLALVTDADRLRRQERERVEQEYVASAMHGDSHDRYERLTSVSSSVDFDQRDNGFCSWLT 130

Human   140 AIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTI 204
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   131 AIFRIKDDEIRDKCGGDAVHYLSFQRHIIGLLVVVGVLSVGIVLPVNFSGDLLENNAYSFGRTTI 195

Human   205 ANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHF 269
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 ANLKSGNNLLWLHTSFAFLYLLLTVYSMRRHTSKMRYKEDDLVKRTLFINGISKYAESEKIKKHF 260

Human   270 EEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPTMINPKPCGHLCCCVVR 334
            ||||||||||||||||||||||||||||||||||||||||||||||||.||||||||||||||||
Mouse   261 EEAYPNCTVLEARPCYNVARLMFLDAERKKAERGKLYFTNLQSKENVPAMINPKPCGHLCCCVVR 325

Human   335 GCEQVEAIEYYTKLEQKLKEDYKREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCR 399
            ||||||||||||||||:|||||:||||||||||||||||||||||||||||||||||||||||||
Mouse   326 GCEQVEAIEYYTKLEQRLKEDYRREKEKVNEKPLGMAFVTFHNETITAIILKDFNVCKCQGCTCR 390

Human   400 GEPRPSSCSESLHISNWTVSYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIII 464
            ||||.|||||:||||||||:|||||||||||||||||||||||||||||||||||||||||||||
Mouse   391 GEPRASSCSEALHISNWTVTYAPDPQNIYWEHLSIRGFIWWLRCLVINVVLFILLFFLTTPAIII 455

Human   465 TTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYT 529
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   456 TTMDKFNVTKPVEYLNNPIITQFFPTLLLWCFSALLPTIVYYSAFFEAHWTRSGENRTTMHKCYT 520

Human   530 FLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDL 594
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   521 FLIFMVLLLPSLGLSSLDLFFRWLFDKKFLAEAAIRFECVFLPDNGAFFVNYVIASAFIGNAMDL 585

Human   595 LRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLM 659
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 LRIPGLLMYMIRLCLARSAAERRNVKRHQAYEFQFGAAYAWMMCVFTVVMTYSITCPIIVPFGLM 650

Human   660 YMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFV 724
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   651 YMLLKHLVDRYNLYYAYLPAKLDKKIHSGAVNQVVAAPILCLFWLLFFSTMRTGFLAPTSMFTFV 715

Human   725 VLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDTVDPRSNGRPPTAAAVPKSAKYIAQVLQDSE 789
            ||||||||||||||||||||||||||||||||||.|..|||||||||.|||||||||||||||||
Mouse   716 VLVITIVICLCHVCFGHFKYLSAHNYKIEHTETDAVSSRSNGRPPTAGAVPKSAKYIAQVLQDSE 780

Human   790 VDGDGDGAPGSSGDEPPSSSSQDEELLMPPDALTDTDFQSCEDSLIENEIHQ 841
            .||||||||||||||||||||||||||||||.||||||||||||||||||||
Mouse   781 GDGDGDGAPGSSGDEPPSSSSQDEELLMPPDGLTDTDFQSCEDSLIENEIHQ 832

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
TMEM63B	XP_016866488.1	RSN1_TM	61..230	CDD:433613	167/168 (99%)
		PHM7_cyt	249..431	CDD:464272	175/181 (97%)
		RSN1_7TM	442..713	CDD:460661	270/270 (100%)
Tmem63b	NP_937810.2	RSN1_TM	52..221	CDD:433613	167/168 (99%)
		Mediates endoplasmic reticulum retention. /evidence=ECO:0000269|PubMed:36496074	86..88		1/1 (100%)
		Intracellular linker IL2, confers mechanosensitivity. /evidence=ECO:0000250|UniProtKB:Q5T3F8	231..426		188/194 (97%)
		PHM7_cyt	240..422	CDD:464272	175/181 (97%)
		RSN1_7TM	433..704	CDD:460661	270/270 (100%)
		Gating helix. /evidence=ECO:0000250|UniProtKB:Q5T3F8	567..599		31/31 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..767		14/18 (78%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	776..818		39/41 (95%)