DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment STYK1 and btl

DIOPT Version :9

Sequence 1:	NP_060893.2	Gene:	STYK1 / 55359	HGNCID:	18889	Length:	422	Species:	Homo sapiens
Sequence 2:	NP_001014583.1	Gene:	btl / 39564	FlyBaseID:	FBgn0285896	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	387	Identity:	104/387 - (26%)
Similarity:	174/387 - (44%)	Gaps:	71/387 - (18%)

- Green bases have known domain annotations that are detailed below.

Human    49 IREQRTQQQRSGPQGIAPVPP------PRDLSWEAGHGGNVALPLKETSVENFLGATTPALAKLQ 107
            |.:|||....:|..|..|...      |.|.:||
  Fly   673 IEKQRTTVSTTGTGGTDPAQGFNEYEFPLDSNWE------------------------------- 706

Human   108 VPREQLS--EVLEQICSGSCGPIFRANMNTGDPSKPK----SVILKALKEPAGLHEVQDFLGRIQ 166
            :||:|||  .:|.:   |:.|.:..|... |.|..|:    .|.:|.:||.....::...:..::
  Fly   707 IPRQQLSLGSILGE---GAFGRVVMAEAE-GLPRSPQLAETIVAVKMVKEEHTDTDMASLVREME 767

Human   167 FHQYLGKHKNLVQLEGCCTEKLPLYMVLEDVAQGDLLSFLWTCRRDV----MTMDGLLYD----- 222
            ..:.:|||.|::.|.|||::..||::::|....|:|..||...|...    ...||.|.|
  Fly   768 VMKMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLIS 832

Human   223 ---LTEKQVYHIGKQVLLALEFLQEKHLFHGDVAARNILMQSDLTAKLCGLGLAYEV----YTRG 280
               |.||::.....|:...:|:|..:...|.|:||||:|:......|:...|||.::    |.|.
  Fly   833 TQHLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRK 897

Human   281 AISSTQTIPLKWLAPERLLLRPASIRADVWSFGILLYEMVTLGAPPYPEV-PPTSILEHLQRRKI 344
              ::...:|:||:|||.|..:....::||||:|:||:|::|.|..|||.: ....:..:|...:.
  Fly   898 --NTNGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQR 960

Human   345 MKRPSSCTHTMYSIMKSCWRWREADRPSPRELRLRLEAAIKTA-----DDEAVLQVPELVVP 401
            |::|:.|:..:|.:|:.||.:....||:..||....:..::.|     |....|.:|.|..|
  Fly   961 MEKPAKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQASSNPNDAYLDLSMPMLETP 1022

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STYK1	NP_060893.2	Pkinase_Tyr	117..380	CDD:285015	82/283 (29%)
STYK1	NP_060893.2	PKc_like	118..381	CDD:304357	81/283 (29%)
btl	NP_001014583.1	IG_like	149..232	CDD:214653
		IGc2	157..215	CDD:197706
		IG	247..336	CDD:214652
		Ig	258..340	CDD:143165
		I-set	394..479	CDD:254352
		IGc2	408..469	CDD:197706
		IG_like	492..583	CDD:214653
		Ig	507..583	CDD:299845
		PKc_like	700..1000	CDD:304357	91/336 (27%)
		TyrKc	712..996	CDD:197581	84/289 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0200
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810