DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment STYK1 and hir-1

DIOPT Version :9

Sequence 1:	NP_060893.2	Gene:	STYK1 / 55359	HGNCID:	18889	Length:	422	Species:	Homo sapiens
Sequence 2:	NP_504458.1	Gene:	hir-1 / 178936	WormBaseID:	WBGene00016059	Length:	903	Species:	Caenorhabditis elegans

Alignment Length:	412	Identity:	108/412 - (26%)
Similarity:	184/412 - (44%)	Gaps:	86/412 - (20%)

- Green bases have known domain annotations that are detailed below.

Human    27 IIVPTLLVTIFLILLGVILWLFIREQ------RTQQQRSGPQGI-----APVPPPRDLSWEAGHG 80
            |::.:|:|.:..|   |::|.:.|::      :.|.::.|...:     .|:...::..||
Worm   478 IVIGSLVVILVAI---VVIWFYFRKKSENMKFKFQMEQVGKNNMNRYIDFPIMAAKNDIWE---- 535

Human    81 GNVALPLKETSVENFLGATTPALAKLQVPREQLSEVLEQICSGSCGPIF--------RANMNTGD 137
                       :|.               |..:....:::.||:.|.::        .|:.:...
Worm   536 -----------IER---------------RNLIIHNDKKLGSGAFGAVYLGKLIGKSLAHKDANS 574

Human   138 P-------SKPKSVILKALKEPAGLHEVQDFLGRIQFHQYLGKHKNLVQLEGCCTEKLPLYMVLE 195
            |       ::...|.:|.|.|.|......:||..|...:.||.|:.||.:..|.||..||.:|:|
Worm   575 PLGINLMRAENCQVAVKMLPEYADEMSKHEFLREIALMKTLGYHERLVNMLACVTESEPLCLVVE 639

Human   196 DVAQGDLLSFLWTCRRDVMTMDGL-----------LYD----LTEKQVYHIGKQVLLALEFLQEK 245
            ....||||.||....:.:|.:|.|           .||    :|.||:.....|:...||:|.:|
Worm   640 YCDNGDLLKFLRERCKYMMKLDDLGINYHDPPENENYDTNMIVTLKQLLQFAVQISYGLEYLSQK 704

Human   246 HLFHGDVAARNILMQSDLTAKLCGLGLAYEVY-------TRGAISSTQTIPLKWLAPERLLLRPA 303
            ...|.||||||:|:......|:...||...:|       ::|.     .:||||::||.:.....
Worm   705 GFVHRDVAARNVLVHEGTACKIGDFGLCRYIYADQSQYKSKGG-----KLPLKWMSPEAIRHYEF 764

Human   304 SIRADVWSFGILLYEMVTLGAPPYPEVPPTSILEHLQRRKIMKRPSSCTHTMYSIMKSCWRWREA 368
            ||::|:|||||||:|::|||..|||.:||..:|..|:....:::|.:|....|.:|..||.....
Worm   765 SIKSDIWSFGILLFEVITLGGSPYPGMPPEDVLPFLEGGGRIEKPDNCPENFYDVMMQCWNADPD 829

Human   369 DRPSPRELRLRLEAAIKTADDE 390
            ||....::|::|...::...::
Worm   830 DRIEFSDVRMQLATQLEDITED 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
STYK1	NP_060893.2	Pkinase_Tyr	117..380	CDD:285015	93/299 (31%)
STYK1	NP_060893.2	PKc_like	118..381	CDD:304357	93/299 (31%)
hir-1	NP_504458.1	fn3	85..163	CDD:365830
hir-1	NP_504458.1	PTKc	547..842	CDD:270623	93/299 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4430
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860