|
Human 1 MESQEFIVLYTHQKMKKSKVWQDGILKITHLGNKAILYDDKGACLESLFLKCLEVKPGDDLESDR 65
||.|||||||||||||||||||||:||.|.||:|||||||||.|||||||||||||||||||:||
Rat 1 MECQEFIVLYTHQKMKKSKVWQDGVLKTTQLGSKAILYDDKGTCLESLFLKCLEVKPGDDLETDR 65
Human 66 YLITVEEVKVAGAIGIVKQNVNKEAPELNSRTFISSGRSLGCQPSGLKRKFTGFQGPRQVPKKMV 130
|||||||.|.||: ..|:.:..:||.|...||.:||.|||||||||||||.||||.|.::|||:.
Rat 66 YLITVEEAKAAGS-RAVEPDGPREALESGPRTLVSSSRSLGCQPSGLKRKATGFQRPYKMPKKVA 129
Human 131 IMESGESAAS---HEAKKTGPTIFSPFCSMPPLFPTVGKKDVNNILADPENIVTYKNRERNAMDF 192
:.|:...||| ..:...||.....|.:..|||.|||.|||....||.|:.||::|.||:.|..
Rat 130 VTENSGPAASLGDGNSGLPGPRFLPTFSNTLPLFSTVGHKDVTTTSADNESPVTFRNTERSDMSL 194
Human 193 SSVFSPSFQINPEVLCEENYFCSPVNSGNKLSDSLLTNEPVKRDSLASHYSGVSQNIRSKAQILA 257
||: |.||.||.:.|.:|:..|.||:|..|.|||||.:||::|:.|.|...||||.|||||||||
Rat 195 SSL-SSSFTINTDTLGKEDKLCFPVSSETKYSDSLLASEPMRRNGLDSFCPGVSQTIRSKAQILA 258
Human 258 LLKSESSSSCEELNSEMTEHFPQKQPQGSLKIATKPKYLIQQEECAEMKSTENLYYQHQSENTMR 322
|||| ||::.::|..|.|.|.|:.||.|.|||.:||| |:|||.:||.||:.:.||||..|
Rat 259 LLKS-SSTTRKDLPDESTGHVPKIQPHGCLKITSKPK-----EDCAETQSTGNLHCEQQSENPTR 317
Human 323 NKSRWAMYLSSQ-SSPIHSSTVDGNDTERKPKAQEDDVNSNLKDLSLQKIIQFVETYAEERKKYN 386
:.||||.||.|| ||| .|..|.|||:.||:||||....||.:|.:|:..:..||..|:.:.|:
Rat 318 STSRWARYLPSQRSSP--CSARDENDTQDKPEAQEDVNIFNLSELLVQQKSELFETCIEKGELYS 380
Human 387 VDQSVGNNDPSWNQEVKLEIPSFNESSSLQVTCSSAENDGILSESDIQEDNKIPFNQNDKGCIKG 451
.|:.: ::..||:.|..| .|||.::||:.|:|||.|:..:|||||.|..:|:|||||:|.||:|
Rat 381 EDKPI-DDCQSWSPEESL-APSFCKNSSVWVSCSSKESVDLLSESDTQYSSKVPFNQNEKVCIQG 443
Human 452 SVLIKENAQEVNTCGTLEKEYEQSESSLPELKHLQIE----SSNNSRISDDITDMISESKMDNES 512
| |..:..|..: ..|||.|| :..|.|.|::|.||| .|.:|||||||.||:|:|..:.|:
Rat 444 S-LSTQGIQGAD-ADTLEPEY-RPLSPLSEIEHKQIEVESSLSTSSRISDDIVDMVSKSSAEREN 505
Human 513 LNSIHESLSNVTQPFLEVTFNLNNFETSDTEEESQESNKISQDSESWVKDILVNDGNSCFQKRSE 577
|:::.:: .||||||:|||:|||.|||:|.|||.:::|||||.|.|::::.| :||.||.|.
Rat 506 LDTVQKA----AQPFLEVSFNLSNFEASDTDEMSQEDSRLSQDSERWEKEVVLID-DSCVQKSSG 565
Human 578 NTNCEEIEGEHLPFLTSVSDKPTVTFPVKETLPSQFCDKTYVGFDMGICKTENTGKEIEE--YSD 640
:..|.||.|:|||.|:|...||........||.|:|||:|.|||:.|..:..||||.:|. |.|
Rat 566 DIGCREIAGKHLPLLSSADGKPKEALTATVTLLSEFCDRTCVGFNSGPHEDANTGKALEGQCYGD 630
Human 641 TLSNFE-SFKWTDAVYGDNKEDANKPIQEVRINYDFALPPNKSKGINMNLHIPHIQNQIA----E 700
|.|:.: |..|::.|.||:||||::.||...|||....|.||.:|||.:||||::.|.|| |
Rat 631 TGSSLDSSLGWSEEVPGDSKEDASESIQGNAINYGSVSPSNKLEGINTSLHIPYLLNTIANPTPE 695
Human 701 NSNLFSEDAQPQPFILGSDLDKNDEHVLPSTSSSDNSVQLLNTNQNHYECIALDKSNTHISNSLF 765
||:|.||...|. :|.|.:|:|||.||...||||.|.|||:|.|:|.|...||:.||.:|:|||
Rat 696 NSDLISEGTPPS--VLQSHIDRNDEWVLSPISSSDISGQLLSTTQDHSEHHELDEFNTQVSSSLF 758
Human 766 YPLGKKHLISKDTEAHISEPEDLGKIRSPPPDHVEVETAREGKQYW-NPRNSSELSGLVNTISIL 829
||:|.||.|.:|:|..|||.::||:|||...:|.:|||.:..:|.| ..:|||||..::|.||.|
Rat 759 YPVGIKHPIYRDSEEDISESKELGRIRSLSCNHFKVETTQRNEQSWATYKNSSELLEVINNISFL 823
Human 830 KSLCEHSTALDSLEILKKKNTVFQQGTQQTYEPDSPPEVRKPFITVVSP---KSPHLHKDSQQIL 891
||..||.|||::|.::|:|: ||....|.:..||..|:.|:...||||. ..||.|:.|||
Rat 824 KSRPEHGTALENLAVVKEKH-VFPHEVQHSRGPDVSPKARRSPATVVSHALLDCPHEHRASQQ-- 885
Human 892 KEDEVELSEPLQSVQFSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGHQVKGSATSGVMVRGH 956
||||||||||||||||||||||
Rat 886 -------------------------------------------PVEFQGHQVKGSATSGVMVRGH 907
Human 957 SSQLGCSQFPDSTEYENFMTE----TPELPSTCMQIDFLQVTSPEENISTLSPVSTFSLNSRDED 1017
|.||||||||||.||::|:|: ||||||||:|.|||||.|||: ||..||..|||.|:|.||
Rat 908 SLQLGCSQFPDSIEYDSFLTDPCVWTPELPSTCVQSDFLQVISPEK-ISAFSPAPTFSFNTRSED 971
Human 1018 FMVEFSETSLKARTLPDDLHFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDLDS 1082
..:||||.|||.||.| |:|.....:|:|.||...||...||.:|||..|||..|||
Rat 972 SELEFSEESLKTRTFP---------GLKNIGFQDNKNFQRFPFLSGASVPFVTLPPDDGPAVLDS 1027
Human 1083 HSYMINSNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGDV-SLNNISTQSKW 1146
.|:||:.:|.|.|||..|||||:|. |||.:..|||:.. |.|| .|...||||||
Rat 1028 CSFMIDDDTREPSGSSRLNLCEESG-LSFDLGLEDQDGI----------PRDVLLLPKSSTQSKW 1081
Human 1147 LKYQNTSQCNVATPNRVDKRITDGFFAEAVSGMHFRDTSERQSDAVNESSLDSVHLQMIKGMLYQ 1211
|||||.|.||.|..||:...:|:...||||||:||..||| :|||:|.||||||||||||
Rat 1082 LKYQNPSHCNSAALNRIASEVTEDLSAEAVSGLHFSHTSE------SESSVDPVHLQMIKGMLYQ 1140
Human 1212 QRQDFSSQDSVSRKKVLSLNLKQTSKTEEIKNVLGGSTCYNYSVKDLQEISGSELCFPSGQKIKS 1276
|:|||:|||.|||:|.|||||.|||:|.|::..||.|...|..|:|.|||:.|:||||:||||.|
Rat 1141 QQQDFTSQDLVSRQKALSLNLNQTSRTGELRTALGSSASSNCRVRDGQEINNSDLCFPNGQKILS 1205
Human 1277 AYLPQRQIHIPAVFQSPAHYKQTFTSCLIEHLNILLFGLAQNLQKALSKVDISFYTSLKGEKLKN 1341
|||||||:||||||||||||:|.|||.:|||||||||||||.|.|||||||||||||.|||.:|:
Rat 1206 AYLPQRQVHIPAVFQSPAHYRQIFTSSIIEHLNILLFGLAQRLYKALSKVDISFYTSSKGEMMKS 1270
Human 1342 AENNVPSCHHSQPAKLVMVKKEGPNKGRLFYTCDGPKADRCKFFKWLEDVTPGYSTQEGARPGMV 1406
.:||.|||||:|||||||||||||||||||||||.||.::||||||||||||...:|..::|.|:
Rat 1271 GKNNSPSCHHNQPAKLVMVKKEGPNKGRLFYTCDKPKGNQCKFFKWLEDVTPEQLSQNESQPNMI 1335
Human 1407 LSDIKSIGLYLRSQKIPLYEECQLLVRKGFDFQRKQYGKLKKFTTVNPEFYNEPKTKLYLKLSRK 1471
.:||||||.|||||||.:|||||||:|||||||:||:|||||..|||||||:|.|:|||||||||
Rat 1336 FNDIKSIGSYLRSQKIAVYEECQLLLRKGFDFQKKQHGKLKKLATVNPEFYSETKSKLYLKLSRK 1400
Human 1472 ERSSAYSKNDLWVVSKTLDFELDTFIACSAFFGPSSINEIEILPLKGYFPSNWPTNMVVHALLVC 1536
|.||.|||.||||:||||||||||||||||||||||:||:|:||||||||||||||:.|||||||
Rat 1401 ESSSVYSKGDLWVISKTLDFELDTFIACSAFFGPSSVNEVELLPLKGYFPSNWPTNITVHALLVC 1465
Human 1537 NASTELTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRVSKRKFIPPAFTNVSTKFELLSLGA 1601
|.|||||.|:|||||||||||||..|||..|....||:|.||||||||||.|::.||||||.|||
Rat 1466 NVSTELTMLQNIQDYFNPATLPLMPYLLAMSQSATVSSKNVSKRKFIPPAITSIKTKFELLHLGA 1530
Human 1602 TLKLASELIQVHKLNKDQATALIQIAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAV 1666
||:||.|||.||:||.|||:||:||||||||..|.|:..|..:|:.|||:|||||||||||||||
Rat 1531 TLQLARELINVHRLNNDQASALMQIAQMMASRGSDEDALEPFSHSLPITVIHGVFGAGKSYLLAV 1595
Human 1667 VILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILP 1731
||||.|:||||.::..:|.|||||||||||||||||||||||||||||.|||||||||||||:||
Rat 1596 VILFLVELFEKCDSEAVGRARPWKLLISSSTNVAVDRVLLGLLSLGFEKFIRVGSVRKIAKPVLP 1660
Human 1732 YSLHAGSENESEQLKELHALMKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFP 1796
|||||.|:|||||||||||||:|:|||.||||||||||||||||||.||||.||||:||||||||
Rat 1661 YSLHASSDNESEQLKELHALMREELTPIERVYVRKSIEQHKLGTNRVLLKQARVVGITCAACPFP 1725
Human 1797 CMNDLKFPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFD 1861
|||||||||||||||||:|||||||||||||||||||||||||||||||||||||.|||||||||
Rat 1726 CMNDLKFPVVVLDECSQMTEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHGNGLEQTLFD 1790
Human 1862 RLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTEIERSPLLEWLPTLCFYNVKGLEQI 1926
||||||||||.|||||||||.||||||||||:|.|:||::|.||||:||||||||||||.|.||:
Rat 1791 RLCLMGHKPIQLRTQYRCHPVISAIANDLFYEGNLVNGISERERSPVLEWLPTLCFYNVTGTEQV 1855
Human 1927 ERDNSFHNVAEATFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQVS 1991
||:|||.|||||.||||||:||||||:.||||||||||||||||:|.||||||..|||:|.|:||
Rat 1856 ERENSFVNVAEAAFTLKLIRSLIASGLEGSMIGVITLYKSQMYKICSLLSAVDVDHPDVKAVEVS 1920
Human 1992 TVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGKRHLLIVGNLACLRKNQLWGRVIQHC 2056
|||||||||||||||||||||||||||||||||||||||:|||||:|:|:|||||||||||||||
Rat 1921 TVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGRRHLLIIGSLSCLRKNQLWGRVIQHC 1985
Human 2057 EGREDGLQHANQYEPQLNHLLKDYFEKQVEEKQKKKSEKEKSKDKSH 2103
:|||||||||:|.||||:.|||:|.|||.|||| ||:||||.|||||
Rat 1986 KGREDGLQHASQCEPQLDRLLKEYLEKQAEEKQ-KKTEKEKLKDKSH 2031
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