DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ZGRF1 and Zgrf1

DIOPT Version :9

Sequence 1:	NP_060862.3	Gene:	ZGRF1 / 55345	HGNCID:	25654	Length:	2104	Species:	Homo sapiens
Sequence 2:	XP_006233356.1	Gene:	Zgrf1 / 310880	RGDID:	1305834	Length:	2031	Species:	Rattus norvegicus

Alignment Length:	2127	Identity:	1346/2127 - (63%)
Similarity:	1588/2127 - (74%)	Gaps:	120/2127 - (5%)

- Green bases have known domain annotations that are detailed below.

Human     1 MESQEFIVLYTHQKMKKSKVWQDGILKITHLGNKAILYDDKGACLESLFLKCLEVKPGDDLESDR 65
            ||.|||||||||||||||||||||:||.|.||:|||||||||.|||||||||||||||||||:||
  Rat     1 MECQEFIVLYTHQKMKKSKVWQDGVLKTTQLGSKAILYDDKGTCLESLFLKCLEVKPGDDLETDR 65

Human    66 YLITVEEVKVAGAIGIVKQNVNKEAPELNSRTFISSGRSLGCQPSGLKRKFTGFQGPRQVPKKMV 130
            |||||||.|.||: ..|:.:..:||.|...||.:||.|||||||||||||.||||.|.::|||:.
  Rat    66 YLITVEEAKAAGS-RAVEPDGPREALESGPRTLVSSSRSLGCQPSGLKRKATGFQRPYKMPKKVA 129

Human   131 IMESGESAAS---HEAKKTGPTIFSPFCSMPPLFPTVGKKDVNNILADPENIVTYKNRERNAMDF 192
            :.|:...|||   ..:...||.....|.:..|||.|||.|||....||.|:.||::|.||:.|..
  Rat   130 VTENSGPAASLGDGNSGLPGPRFLPTFSNTLPLFSTVGHKDVTTTSADNESPVTFRNTERSDMSL 194

Human   193 SSVFSPSFQINPEVLCEENYFCSPVNSGNKLSDSLLTNEPVKRDSLASHYSGVSQNIRSKAQILA 257
            ||: |.||.||.:.|.:|:..|.||:|..|.|||||.:||::|:.|.|...||||.|||||||||
  Rat   195 SSL-SSSFTINTDTLGKEDKLCFPVSSETKYSDSLLASEPMRRNGLDSFCPGVSQTIRSKAQILA 258

Human   258 LLKSESSSSCEELNSEMTEHFPQKQPQGSLKIATKPKYLIQQEECAEMKSTENLYYQHQSENTMR 322
            |||| ||::.::|..|.|.|.|:.||.|.|||.:|||     |:|||.:||.||:.:.||||..|
  Rat   259 LLKS-SSTTRKDLPDESTGHVPKIQPHGCLKITSKPK-----EDCAETQSTGNLHCEQQSENPTR 317

Human   323 NKSRWAMYLSSQ-SSPIHSSTVDGNDTERKPKAQEDDVNSNLKDLSLQKIIQFVETYAEERKKYN 386
            :.||||.||.|| |||  .|..|.|||:.||:||||....||.:|.:|:..:..||..|:.:.|:
  Rat   318 STSRWARYLPSQRSSP--CSARDENDTQDKPEAQEDVNIFNLSELLVQQKSELFETCIEKGELYS 380

Human   387 VDQSVGNNDPSWNQEVKLEIPSFNESSSLQVTCSSAENDGILSESDIQEDNKIPFNQNDKGCIKG 451
            .|:.: ::..||:.|..| .|||.::||:.|:|||.|:..:|||||.|..:|:|||||:|.||:|
  Rat   381 EDKPI-DDCQSWSPEESL-APSFCKNSSVWVSCSSKESVDLLSESDTQYSSKVPFNQNEKVCIQG 443

Human   452 SVLIKENAQEVNTCGTLEKEYEQSESSLPELKHLQIE----SSNNSRISDDITDMISESKMDNES 512
            | |..:..|..: ..|||.|| :..|.|.|::|.|||    .|.:|||||||.||:|:|..:.|:
  Rat   444 S-LSTQGIQGAD-ADTLEPEY-RPLSPLSEIEHKQIEVESSLSTSSRISDDIVDMVSKSSAEREN 505

Human   513 LNSIHESLSNVTQPFLEVTFNLNNFETSDTEEESQESNKISQDSESWVKDILVNDGNSCFQKRSE 577
            |:::.::    .||||||:|||:|||.|||:|.|||.:::|||||.|.|::::.| :||.||.|.
  Rat   506 LDTVQKA----AQPFLEVSFNLSNFEASDTDEMSQEDSRLSQDSERWEKEVVLID-DSCVQKSSG 565

Human   578 NTNCEEIEGEHLPFLTSVSDKPTVTFPVKETLPSQFCDKTYVGFDMGICKTENTGKEIEE--YSD 640
            :..|.||.|:|||.|:|...||........||.|:|||:|.|||:.|..:..||||.:|.  |.|
  Rat   566 DIGCREIAGKHLPLLSSADGKPKEALTATVTLLSEFCDRTCVGFNSGPHEDANTGKALEGQCYGD 630

Human   641 TLSNFE-SFKWTDAVYGDNKEDANKPIQEVRINYDFALPPNKSKGINMNLHIPHIQNQIA----E 700
            |.|:.: |..|::.|.||:||||::.||...|||....|.||.:|||.:||||::.|.||    |
  Rat   631 TGSSLDSSLGWSEEVPGDSKEDASESIQGNAINYGSVSPSNKLEGINTSLHIPYLLNTIANPTPE 695

Human   701 NSNLFSEDAQPQPFILGSDLDKNDEHVLPSTSSSDNSVQLLNTNQNHYECIALDKSNTHISNSLF 765
            ||:|.||...|.  :|.|.:|:|||.||...||||.|.|||:|.|:|.|...||:.||.:|:|||
  Rat   696 NSDLISEGTPPS--VLQSHIDRNDEWVLSPISSSDISGQLLSTTQDHSEHHELDEFNTQVSSSLF 758

Human   766 YPLGKKHLISKDTEAHISEPEDLGKIRSPPPDHVEVETAREGKQYW-NPRNSSELSGLVNTISIL 829
            ||:|.||.|.:|:|..|||.::||:|||...:|.:|||.:..:|.| ..:|||||..::|.||.|
  Rat   759 YPVGIKHPIYRDSEEDISESKELGRIRSLSCNHFKVETTQRNEQSWATYKNSSELLEVINNISFL 823

Human   830 KSLCEHSTALDSLEILKKKNTVFQQGTQQTYEPDSPPEVRKPFITVVSP---KSPHLHKDSQQIL 891
            ||..||.|||::|.::|:|: ||....|.:..||..|:.|:...||||.   ..||.|:.|||
  Rat   824 KSRPEHGTALENLAVVKEKH-VFPHEVQHSRGPDVSPKARRSPATVVSHALLDCPHEHRASQQ-- 885

Human   892 KEDEVELSEPLQSVQFSSSGSKEETAFQAVIPKQIERKTCDPKPVEFQGHQVKGSATSGVMVRGH 956
                                                       ||||||||||||||||||||||
  Rat   886 -------------------------------------------PVEFQGHQVKGSATSGVMVRGH 907

Human   957 SSQLGCSQFPDSTEYENFMTE----TPELPSTCMQIDFLQVTSPEENISTLSPVSTFSLNSRDED 1017
            |.||||||||||.||::|:|:    ||||||||:|.|||||.|||: ||..||..|||.|:|.||
  Rat   908 SLQLGCSQFPDSIEYDSFLTDPCVWTPELPSTCVQSDFLQVISPEK-ISAFSPAPTFSFNTRSED 971

Human  1018 FMVEFSETSLKARTLPDDLHFLNLEGMKKSRSLENENLQRLSLLSRTQVPLITLPRTDGPPDLDS 1082
            ..:||||.|||.||.|         |:|.....:|:|.||...||...||.:|||..|||..|||
  Rat   972 SELEFSEESLKTRTFP---------GLKNIGFQDNKNFQRFPFLSGASVPFVTLPPDDGPAVLDS 1027

Human  1083 HSYMINSNTYESSGSPMLNLCEKSAVLSFSIEPEDQNETFFSEESREVNPGDV-SLNNISTQSKW 1146
            .|:||:.:|.|.|||..|||||:|. |||.:..|||:..          |.|| .|...||||||
  Rat  1028 CSFMIDDDTREPSGSSRLNLCEESG-LSFDLGLEDQDGI----------PRDVLLLPKSSTQSKW 1081

Human  1147 LKYQNTSQCNVATPNRVDKRITDGFFAEAVSGMHFRDTSERQSDAVNESSLDSVHLQMIKGMLYQ 1211
            |||||.|.||.|..||:...:|:...||||||:||..|||      :|||:|.||||||||||||
  Rat  1082 LKYQNPSHCNSAALNRIASEVTEDLSAEAVSGLHFSHTSE------SESSVDPVHLQMIKGMLYQ 1140

Human  1212 QRQDFSSQDSVSRKKVLSLNLKQTSKTEEIKNVLGGSTCYNYSVKDLQEISGSELCFPSGQKIKS 1276
            |:|||:|||.|||:|.|||||.|||:|.|::..||.|...|..|:|.|||:.|:||||:||||.|
  Rat  1141 QQQDFTSQDLVSRQKALSLNLNQTSRTGELRTALGSSASSNCRVRDGQEINNSDLCFPNGQKILS 1205

Human  1277 AYLPQRQIHIPAVFQSPAHYKQTFTSCLIEHLNILLFGLAQNLQKALSKVDISFYTSLKGEKLKN 1341
            |||||||:||||||||||||:|.|||.:|||||||||||||.|.|||||||||||||.|||.:|:
  Rat  1206 AYLPQRQVHIPAVFQSPAHYRQIFTSSIIEHLNILLFGLAQRLYKALSKVDISFYTSSKGEMMKS 1270

Human  1342 AENNVPSCHHSQPAKLVMVKKEGPNKGRLFYTCDGPKADRCKFFKWLEDVTPGYSTQEGARPGMV 1406
            .:||.|||||:|||||||||||||||||||||||.||.::||||||||||||...:|..::|.|:
  Rat  1271 GKNNSPSCHHNQPAKLVMVKKEGPNKGRLFYTCDKPKGNQCKFFKWLEDVTPEQLSQNESQPNMI 1335

Human  1407 LSDIKSIGLYLRSQKIPLYEECQLLVRKGFDFQRKQYGKLKKFTTVNPEFYNEPKTKLYLKLSRK 1471
            .:||||||.|||||||.:|||||||:|||||||:||:|||||..|||||||:|.|:|||||||||
  Rat  1336 FNDIKSIGSYLRSQKIAVYEECQLLLRKGFDFQKKQHGKLKKLATVNPEFYSETKSKLYLKLSRK 1400

Human  1472 ERSSAYSKNDLWVVSKTLDFELDTFIACSAFFGPSSINEIEILPLKGYFPSNWPTNMVVHALLVC 1536
            |.||.|||.||||:||||||||||||||||||||||:||:|:||||||||||||||:.|||||||
  Rat  1401 ESSSVYSKGDLWVISKTLDFELDTFIACSAFFGPSSVNEVELLPLKGYFPSNWPTNITVHALLVC 1465

Human  1537 NASTELTTLKNIQDYFNPATLPLTQYLLTTSSPTIVSNKRVSKRKFIPPAFTNVSTKFELLSLGA 1601
            |.|||||.|:|||||||||||||..|||..|....||:|.||||||||||.|::.||||||.|||
  Rat  1466 NVSTELTMLQNIQDYFNPATLPLMPYLLAMSQSATVSSKNVSKRKFIPPAITSIKTKFELLHLGA 1530

Human  1602 TLKLASELIQVHKLNKDQATALIQIAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAV 1666
            ||:||.|||.||:||.|||:||:||||||||..|.|:..|..:|:.|||:|||||||||||||||
  Rat  1531 TLQLARELINVHRLNNDQASALMQIAQMMASRGSDEDALEPFSHSLPITVIHGVFGAGKSYLLAV 1595

Human  1667 VILFFVQLFEKSEAPTIGNARPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILP 1731
            ||||.|:||||.::..:|.|||||||||||||||||||||||||||||.|||||||||||||:||
  Rat  1596 VILFLVELFEKCDSEAVGRARPWKLLISSSTNVAVDRVLLGLLSLGFEKFIRVGSVRKIAKPVLP 1660

Human  1732 YSLHAGSENESEQLKELHALMKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFP 1796
            |||||.|:|||||||||||||:|:|||.||||||||||||||||||.||||.||||:||||||||
  Rat  1661 YSLHASSDNESEQLKELHALMREELTPIERVYVRKSIEQHKLGTNRVLLKQARVVGITCAACPFP 1725

Human  1797 CMNDLKFPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFD 1861
            |||||||||||||||||:|||||||||||||||||||||||||||||||||||||.|||||||||
  Rat  1726 CMNDLKFPVVVLDECSQMTEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHGNGLEQTLFD 1790

Human  1862 RLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTEIERSPLLEWLPTLCFYNVKGLEQI 1926
            ||||||||||.|||||||||.||||||||||:|.|:||::|.||||:||||||||||||.|.||:
  Rat  1791 RLCLMGHKPIQLRTQYRCHPVISAIANDLFYEGNLVNGISERERSPVLEWLPTLCFYNVTGTEQV 1855

Human  1927 ERDNSFHNVAEATFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAVDFHHPDIKTVQVS 1991
            ||:|||.|||||.||||||:||||||:.||||||||||||||||:|.||||||..|||:|.|:||
  Rat  1856 ERENSFVNVAEAAFTLKLIRSLIASGLEGSMIGVITLYKSQMYKICSLLSAVDVDHPDVKAVEVS 1920

Human  1992 TVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGKRHLLIVGNLACLRKNQLWGRVIQHC 2056
            |||||||||||||||||||||||||||||||||||||||:|||||:|:|:|||||||||||||||
  Rat  1921 TVDAFQGAEKEIIILSCVRTRQVGFIDSEKRMNVALTRGRRHLLIIGSLSCLRKNQLWGRVIQHC 1985

Human  2057 EGREDGLQHANQYEPQLNHLLKDYFEKQVEEKQKKKSEKEKSKDKSH 2103
            :|||||||||:|.||||:.|||:|.|||.|||| ||:||||.|||||
  Rat  1986 KGREDGLQHASQCEPQLDRLLKEYLEKQAEEKQ-KKTEKEKLKDKSH 2031

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ZGRF1	NP_060862.3	AAA_11	1614..1844	CDD:289831	193/229 (84%)
		DNA2	<1739..2057	CDD:224037	279/317 (88%)
		AAA_12	1855..2039	CDD:289832	156/183 (85%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	2085..2104		15/19 (79%)
		DUF2439	4..73	CDD:287368	62/68 (91%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..359		14/23 (61%)
		zf-GRF	1347..1391	CDD:284302	38/43 (88%)
Zgrf1	XP_006233356.1	DUF2439	3..75	CDD:402138	63/71 (89%)
		zf-GRF	1276..1320	CDD:399670	38/43 (88%)
		DEAD-like_helicase_N	1543..1807	CDD:421690	225/263 (86%)
		AAA_12	1784..1968	CDD:404073	156/183 (85%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	850	1.000	Domainoid score	I2315
eggNOG	1	0.900	-	-		E1_COG1112
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H34708
Inparanoid	1	1.050	1847	1.000	Inparanoid score	I1749
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG34427
OrthoDB	1	1.010	-	-		D13809at40674
OrthoFinder	1	1.000	-	-		FOG0013492
OrthoInspector	1	1.000	-	-		oto136940
orthoMCL	1	0.900	-	-		OOG6_107319
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X11010
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	14.280