Protein Alignment ZGRF1 and smg-2

DIOPT Version :10

• Sequence 1: NP_060862.3
• Gene: ZGRF1 / 55345
• HGNCID: 25654
• Length: 2104
• Species: Homo sapiens
• Sequence 2: NP_490829.1
• Gene: smg-2 / 171696
• WormBaseID: WBGene00004880
• Length: 1069
• Species: Caenorhabditis elegans
• Alignment Length: 493
• Identity: 155/493 - (31%)
• Similarity: 245/493 - (49%)
• Gaps: 87/493 - (17%)

Human  1614 KLNKDQATALIQIAQMMASHESIEEVKELQTHTFPITIIHGVFGAGKSYLLAVVILFFVQLFEKS 1678
            :||..|..|:.|:.                  |.|:::|.|..|.||:.:.|.::...||   |:
 Worm   445 ELNSSQMQAVKQVL------------------TRPLSLIQGPPGTGKTVVSATIVYHLVQ---KT 488

Human  1679 EAPTIGNARPWKLLISSSTNVAVDRVLLGLLSLGFENFIRVGSVRKIAKPILPY-------SLHA 1736
            |    ||     :|:.|.:|:|||.:...:...|.:........|:.::..:||       .:..
 Worm   489 E----GN-----VLVCSPSNIAVDHLAEKIHKTGLKVVRLCARSREHSETTVPYLTLQHQLKVMG 544

Human  1737 GSE-NESEQLK----ELHALMKEDLTPTERVYVRKSIEQHKLGTNRTLLKQVRVVGVTCAACPFP 1796
            |:| .:..|||    ||.  .|:||    |....|.:::|:      ||....|:..||::....
 Worm   545 GAELQKLIQLKDEAGELE--FKDDL----RYMQLKRVKEHE------LLAAADVICCTCSSAADA 597

Human  1797 CMNDLKFPVVVLDECSQITEPASLLPIARFECEKLILVGDPKQLPPTIQGSDAAHENGLEQTLFD 1861
            .::.::...|::||.:|.|||..|:.|.| ...:|:||||..||.|.:....||.. ||.|:||:
 Worm   598 RLSKIRTRTVLIDESTQATEPEILVSIMR-GVRQLVLVGDHCQLGPVVICKKAAIA-GLSQSLFE 660

Human  1862 RLCLMGHKPILLRTQYRCHPAISAIANDLFYKGALMNGVTEIERSPL-LEW------LPTLCFYN 1919
            ||.|:|.:|..|:.|||.||.:|...:::||.|:|.|||||.:|... ::|      .|.. |::
 Worm   661 RLVLLGIRPFRLQVQYRMHPVLSEFPSNVFYDGSLQNGVTENDRHMTGVDWHWPKPNKPAF-FWH 724

Human  1920 VKGLEQIERD-NSFHNVAEATFTLKLIQSLIASGIAGSMIGVITLYKSQMYKLCHLLSAVDFHHP 1983
            ..|.|::... .||.|..||....||:..||.:|:....|||||.|:.|...:      |::.|.
 Worm   725 CSGSEELSASGTSFLNRTEAANVEKLVSKLIKAGVQPHQIGVITPYEGQRSFI------VNYMHT 783

Human  1984 D-------IKTVQVSTVDAFQGAEKEIIILSCVRTRQ---VGFIDSEKRMNVALTRGKRHLLIVG 2038
            .       .:.|::::||||||.||:.||::|||:..   :||:...:|:|||:||.|..|::||
 Worm   784 QGTLNSKLYENVEIASVDAFQGREKDYIIVTCVRSNDILGIGFLSDPRRLNVAITRAKYGLVLVG 848

Human  2039 NLACLRKNQLWGRVIQHCEGREDGLQHANQYEPQLNHL 2076
            |...|.::.||..:|.|.:.:|      ..||..:|.|
 Worm   849 NAKVLARHDLWHELINHYKSKE------MLYEGPINAL 880

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ZGRF1	NP_060862.3	DUF2439	4..74	CDD:463065
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	335..359
		zf-GRF	1347..1391	CDD:462017
		DNA2	<1686..2057	CDD:440729	131/400 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2085..2104
smg-2	NP_490829.1	UPF1_Zn_bind	93..243	CDD:401391
		1B_UPF1-like	297..387	CDD:394815
		DEXXQc_UPF1	445..677	CDD:350797	79/275 (29%)
		AAA_12	654..851	CDD:463780	77/203 (38%)