Protein Alignment PPP3CC and CanA-14F

DIOPT Version :10

• Sequence 1: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_727985.2
• Gene: CanA-14F / 8674098
• FlyBaseID: FBgn0267912
• Length: 584
• Species: Drosophila melanogaster
• Alignment Length: 520
• Identity: 380/520 - (73%)
• Similarity: 437/520 - (84%)
• Gaps: 35/520 - (6%)

Human     4 RRFHLSTTDRVIKAVPFPPTQRLTFKEVFE--NGKPKVDVLKNHLVKEGRLEEEVALKIINDGAA 66
            :|..:||.:|||.:|.|||:::||..:||:  .|||:.||||.|.:.|||:||..||:||.:||.
  Fly    80 KRSTISTKERVIDSVAFPPSRKLTCADVFDARTGKPQHDVLKQHFILEGRIEESAALRIIQEGAT 144

Human    67 ILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWS 131
            :||.|||||:::||:||||||||||:|||||||:||||:.|:|||||||||||||||||||||||
  Fly   145 LLRTEKTMIDIEAPVTVCGDIHGQFYDLMKLFEIGGSPATTKYLFLGDYVDRGYFSIECVLYLWS 209

Human   132 LKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHG 196
            |||.:|:|||||||||||||||:||||||||:|||||:||||||:.|||||||||:|||||||||
  Fly   210 LKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHG 274

Human   197 GMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAV 261
            |:||||..|:|||:||||.|||||||:||||||||.||:||||..:.||||:||||||||||.|.
  Fly   275 GLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSYAAC 339

Human   262 CEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMN 326
            |:||||||||||||||||||||||||||||.||||||||||||||||||||||||||||||||||
  Fly   340 CDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMN 404

Human   327 IRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--------ISDDEAEDHY 383
            |||||||||||||||||||||||||||||||||||||||||||||||        :|||||
  Fly   405 IRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEA---- 465

Human   384 IPSYQKGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIE 448
                     .:|||:||||||||||||||||:||:||||||.||||||||.||||.||||||::
  Fly   466 ---------ALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQSL- 520

Human   449 TATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSI--HAGGPMKSVTSAHSHAAH 511
                     :.|::|||..|||.||.||:|||.:|||||||:|:.  .|....||:::|.:.||:
  Fly   521 ---------KNAMQGFSPNHKITSFAEAKGLDAVNERMPPRRDATPSPAEEGQKSLSAAAAAAAN 576

Human   512  511
              Fly   577  576

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	252/303 (83%)
		Catalytic. /evidence=ECO:0000305	52..343		245/290 (84%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		21/21 (100%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417		5/6 (83%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490		16/21 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521		15/34 (44%)
CanA-14F	NP_727985.2	MPP_PP2B	115..419	CDD:277361	252/303 (83%)