Protein Alignment PPP3CC and CNA1

DIOPT Version :10

• Sequence 1: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_013537.1
• Gene: CNA1 / 851153
• SGDID: S000004425
• Length: 553
• Species: Saccharomyces cerevisiae
• Alignment Length: 511
• Identity: 266/511 - (52%)
• Similarity: 355/511 - (69%)
• Gaps: 52/511 - (10%)

Human     8 LSTTDRVIKAVPFPPTQRLTFKEVFEN--GKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQ 70
            :||.||.|.:||....:..:.:|||::  |.|....|:.|...||||.:|.|:||:|.....|.:
Yeast    39 ISTKDRPIASVPAITGKIPSDEEVFDSKTGLPNHSFLREHFFHEGRLSKEQAIKILNMSTVALSK 103

Human    71 EKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKIN 135
            |..::::.||||:|||||||::||:|||||||.|:...|||||||||||.||.||::||:|||:|
Yeast   104 EPNLLKLKAPITICGDIHGQYYDLLKLFEVGGDPAEIDYLFLGDYVDRGAFSFECLIYLYSLKLN 168

Human   136 HPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSP 200
            :....::|||||||:|||.|||||.|...||..:|||||..:|:.||||||:|.|:.|||||:||
Yeast   169 NLGRFWMLRGNHECKHLTSYFTFKNEMLHKYDMEVYDACCRSFNVLPLAALMNGQYFCVHGGISP 233

Human   201 EITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDY-----GNE--KTLEHYTHNTVRGCSYFYSY 258
            |:.|::|:.|::||.|.|:.|.:|||||:||.|:|     |:|  ::.:.:..|::||||:.:::
Yeast   234 ELKSVEDVNKINRFREIPSRGLMCDLLWADPVENYDDARDGSEFDQSEDEFVPNSLRGCSFAFTF 298

Human   259 PAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENN 323
            .|.|:||:.|.||||||||||||||||||:.::.||||||||:||||||||.|:|||||||||.|
Yeast   299 KASCKFLKANGLLSIIRAHEAQDAGYRMYKNNKVTGFPSLITMFSAPNYLDTYHNKAAVLKYEEN 363

Human   324 VMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAE-------- 380
            |||||||:.||||||||:|||||||||||||||||.|||::|||||:.||  |.|:|
Yeast   364 VMNIRQFHMSPHPYWLPDFMDVFTWSLPFVGEKVTSMLVSILNICSEQEL--DPESEPKAAEETV 426

Human   381 --------DHYIPSYQKGSTTV-----RKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPT 432
                    :...||.:|.|:.:     |::.:||||.||.|::|:||:||:|||.|..||.:. .
Yeast   427 KARANATKETGTPSDEKASSAILEDETRRKALRNKILAIAKVSRMFSVLREESEKVEYLKTMN-A 490

Human   433 GTLPLGVLSGGKQTIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPP 488
            |.||.|.|:.|.:                   .|...:.:||:||..|.|||::||
Yeast   491 GVLPRGALARGTE-------------------GLNETLSTFEKARKEDLINEKLPP 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	184/310 (59%)
		Catalytic. /evidence=ECO:0000305	52..343		179/297 (60%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		18/21 (86%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409		7/13 (54%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417		3/6 (50%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490		10/21 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521		6/9 (67%)
CNA1	NP_013537.1	MPP_PP2B	70..381	CDD:277361	184/310 (59%)