Protein Alignment PPP3CC and Pp2B-14D

DIOPT Version :9

• Sequence 1: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_001245715.1
• Gene: Pp2B-14D / 32624
• FlyBaseID: FBgn0011826
• Length: 570
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 383/528 - (72%)
• Similarity: 434/528 - (82%)
• Gaps: 42/528 - (7%)

Human     1 MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFE--NGKPKVDVLKNHLVKEGRLEEEVALKIIND 63
            :.|....::|.:||:.:|||||:.:||..|||:  .|||..::||.|.:.|||:||..|||||.|
  Fly    69 LHGGHTAVNTKERVVDSVPFPPSHKLTLAEVFDQRTGKPNHELLKQHFILEGRIEEAPALKIIQD 133

Human    64 GAAILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLY 128
            |||:||||||||:::||:||||||||||:||||||||||||::|:||||||||||||||||||||
  Fly   134 GAALLRQEKTMIDIEAPVTVCGDIHGQFYDLMKLFEVGGSPASTKYLFLGDYVDRGYFSIECVLY 198

Human   129 LWSLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLC 193
            ||||||.:|:|||||||||||||||:||||||||:|||||:||||||:.|||||||||:||||||
  Fly   199 LWSLKITYPQTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLC 263

Human   194 VHGGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSY 258
            ||||:||||..|:|||:||||.|||||||:||||||||.||:||||..:.||||:||||||||||
  Fly   264 VHGGLSPEIHELEDIRRLDRFKEPPAFGPMCDLLWSDPLEDFGNEKNSDFYTHNSVRGCSYFYSY 328

Human   259 PAVCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENN 323
            .|.|:||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||||
  Fly   329 AACCDFLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENN 393

Human   324 VMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDEL--------ISDDEAE 380
            ||||||||||||||||||||||||||||||||||||||||||||||||||        :|||||
  Fly   394 VMNIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELMTEESEEPLSDDEA- 457

Human   381 DHYIPSYQKGSTTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQ 445
                        .:|||:||||||||||||||||:||:||||||.||||||||.||||.||||||
  Fly   458 ------------ALRKEVIRNKIRAIGKMARVFSVLREESESVLQLKGLTPTGALPLGALSGGKQ 510

Human   446 TIETATVEAVEAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKSVTSAHSHAA 510
            ::          :.|::|||..|||.||.||:|||.:|||||||:|.     |.......:.|
  Fly   511 SL----------KNAMQGFSPNHKITSFAEAKGLDAVNERMPPRRDQ-----PPTPSEDPNQH-- 558

Human   511 HRSDQGKK 518
              |.||.|
  Fly   559 --SQQGGK 564

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	255/303 (84%)
		Catalytic. /evidence=ECO:0000305	52..343		250/290 (86%)
		PP2Ac	54..325	CDD:197547	231/270 (86%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		21/21 (100%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417		5/6 (83%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490		16/21 (76%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521		15/39 (38%)
Pp2B-14D	NP_001245715.1	MPP_PP2B	107..411	CDD:277361	255/303 (84%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142537
Domainoid	1	1.000	394	1.000	Domainoid score	I765
eggNOG	1	0.900	-	-		E1_COG0639
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	815	1.000	Inparanoid score	I479
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53795
OrthoDB	1	1.010	-	-		D194337at33208
OrthoFinder	1	1.000	-	-		FOG0000983
OrthoInspector	1	1.000	-	-		mtm8621
orthoMCL	1	0.900	-	-		OOG6_100566
Panther	1	1.100	-	-	O	PTHR45673
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R954
SonicParanoid	1	1.000	-	-		X576
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.800