Protein Alignment PPP3CC and tax-6

DIOPT Version :10

• Sequence 1: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_001367052.1
• Gene: tax-6 / 177943
• WormBaseID: WBGene00006527
• Length: 545
• Species: Caenorhabditis elegans
• Alignment Length: 494
• Identity: 350/494 - (70%)
• Similarity: 416/494 - (84%)
• Gaps: 8/494 - (1%)

Human    11 TDRVIKAVPFPPTQRLTFKEVFE--NGKPKVDVLKNHLVKEGRLEEEVALKIINDGAAILRQEKT 73
            |:|.:|.|.||.::|||..:|::  .|||:.:||::|.:||||:|||.|:::|.:.:::.|.|||
 Worm    38 TERFVKTVQFPVSERLTVDQVYDRRTGKPRHEVLRDHFIKEGRIEEEAAIRVIQECSSLFRNEKT 102

Human    74 MIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLWSLKINHPK 138
            |:|::||:||||||||||:||||||||||||:.|:||||||||||||||||||||||:|||.:|.
 Worm   103 MLEIEAPVTVCGDIHGQFYDLMKLFEVGGSPATTKYLFLGDYVDRGYFSIECVLYLWALKICYPT 167

Human   139 TLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVHGGMSPEIT 203
            |||||||||||||||:||||||||:|||||:|||.|||:||.||||||:||||||||||:||||.
 Worm   168 TLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDVCMESFDALPLAALMNQQFLCVHGGLSPEIH 232

Human   204 SLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPAVCEFLQNN 268
            :|:|||::|||.|||||||:||||||||.||:|||:..|.::||:||||||||||.|.|:|||:|
 Worm   233 TLEDIRRIDRFKEPPAFGPMCDLLWSDPLEDFGNERNSEQFSHNSVRGCSYFYSYAACCDFLQHN 297

Human   269 NLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 333
            ||||||||||||||||||||||||||||||||||||||||||||||||:||||||||||||||||
 Worm   298 NLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAILKYENNVMNIRQFNCS 362

Human   334 PHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEDHYIPSYQKGSTTVRKEI 398
            |||||||||||||||||||||||||||||::|||||||||::  |.:|.: .....|..:.|||:
 Worm   363 PHPYWLPNFMDVFTWSLPFVGEKVTEMLVHILNICSDDELMA--ECDDTF-EGADGGVGSARKEV 424

Human   399 IRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETA-TVEAVEAREAIR 462
            ||:||||||||||.||:||.||||||.||||...|.||.|.||.|:..:..| .:|...|.|:
 Worm   425 IRHKIRAIGKMARAFSVLRHESESVLQLKGLNAGGKLPQGALSEGRTGLNAAYRIEQSVAAES-- 487

Human   463 GFSLQHKIRSFEEARGLDRINERMPPRKDSIHAGGPMKS 501
            |....|.|:||||||.||:|||||||...:..|..|.:|
 Worm   488 GCDSGHLIQSFEEARRLDKINERMPPTMATPPAQSPSQS 526

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	242/303 (80%)
		Catalytic. /evidence=ECO:0000305	52..343		236/290 (81%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		19/21 (90%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409		11/13 (85%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417		4/6 (67%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490		17/21 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521		11/22 (50%)
tax-6	NP_001367052.1	MPP_PP2B	66..370	CDD:277361	242/303 (80%)