Protein Alignment PPP3CC and Ppp3cc

DIOPT Version :10

• Sequence 1: NP_001230903.1
• Gene: PPP3CC / 5533
• HGNCID: 9316
• Length: 521
• Species: Homo sapiens
• Sequence 2: XP_008769035.1
• Gene: Ppp3cc / 171378
• RGDID: 621616
• Length: 515
• Species: Rattus norvegicus
• Alignment Length: 521
• Identity: 450/521 - (86%)
• Similarity: 483/521 - (92%)
• Gaps: 9/521 - (1%)

Human     1 MSGRRFHLSTTDRVIKAVPFPPTQRLTFKEVFENGKPKVDVLKNHLVKEGRLEEEVALKIINDGA 65
            |||||...|||:|||||||||||:|||.||||||||||:||||||||||||:||:||||||||||
  Rat     1 MSGRRPQFSTTERVIKAVPFPPTRRLTLKEVFENGKPKMDVLKNHLVKEGRVEEDVALKIINDGA 65

Human    66 AILRQEKTMIEVDAPITVCGDIHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLW 130
            |||:|||||:||:||||||||:|||||||||||||||||||||||||||||||||||||||||||
  Rat    66 AILKQEKTMLEVEAPITVCGDVHGQFFDLMKLFEVGGSPSNTRYLFLGDYVDRGYFSIECVLYLW 130

Human   131 SLKINHPKTLFLLRGNHECRHLTDYFTFKQECRIKYSEQVYDACMETFDCLPLAALLNQQFLCVH 195
            |||||||||||||||||||||||:||||||||||||||.||:|||.|||||||||||||||||||
  Rat   131 SLKINHPKTLFLLRGNHECRHLTEYFTFKQECRIKYSELVYEACMHTFDCLPLAALLNQQFLCVH 195

Human   196 GGMSPEITSLDDIRKLDRFTEPPAFGPVCDLLWSDPSEDYGNEKTLEHYTHNTVRGCSYFYSYPA 260
            ||||||||.||||||||||.||||||||||||||||.||||:||||||||||||||||||:||||
  Rat   196 GGMSPEITCLDDIRKLDRFAEPPAFGPVCDLLWSDPLEDYGSEKTLEHYTHNTVRGCSYFFSYPA 260

Human   261 VCEFLQNNNLLSIIRAHEAQDAGYRMYRKSQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM 325
            ||||||||:||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
  Rat   261 VCEFLQNNSLLSIIRAHEAQDAGYRMYRKNQATGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM 325

Human   326 NIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELISDDEAEDHYIPSYQKG 390
            ||||||||||||||||||||||||||||||||||||||:||||||:|: |..|.|||||.|..||
  Rat   326 NIRQFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDEEM-SLVEEEDHYISSCPKG 389

Human   391 STTVRKEIIRNKIRAIGKMARVFSILRQESESVLTLKGLTPTGTLPLGVLSGGKQTIETATVEAV 455
            :|:||||:|||||||||||||||::||:|||:||.|||||||||||||||||||||||||.::|.
  Rat   390 ATSVRKEVIRNKIRAIGKMARVFTVLREESENVLILKGLTPTGTLPLGVLSGGKQTIETAKLQAA 454

Human   456 EAREAIRGFSLQHKIRSFEEARGLDRINERMPPRKDSI--HAGGPMKSVTSAHSHAAHRSDQGKK 518
            |.|||||||::.|:|||||||||||||||||||||::.  |..|      ..|.|.:.|||.|||
  Rat   455 EEREAIRGFTIAHRIRSFEEARGLDRINERMPPRKEASYHHDAG------KTHPHPSKRSDHGKK 513

Human   519 A 519
            |
  Rat   514 A 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CC	NP_001230903.1	MPP_PP2B	37..341	CDD:277361	285/303 (94%)
		Catalytic. /evidence=ECO:0000305	52..343		273/290 (94%)
		SAPNY motif. /evidence=ECO:0000250|UniProtKB:Q08209	303..307		3/3 (100%)
		Calcineurin B binding. /evidence=ECO:0000250|UniProtKB:P16298	344..366		20/21 (95%)
		Calmodulin-binding. /evidence=ECO:0000250|UniProtKB:P16298	395..409		12/13 (92%)
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	410..417		4/6 (67%)
		Autoinhibitory domain. /evidence=ECO:0000250|UniProtKB:P16298	468..490		20/21 (95%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	480..521		22/42 (52%)
Ppp3cc	XP_008769035.1	MPP_PP2B	37..341	CDD:277361	285/303 (94%)