Protein Alignment PPP3CB and CanA1

DIOPT Version :10

• Sequence 1: XP_047281382.1
• Gene: PPP3CB / 5532
• HGNCID: 9315
• Length: 534
• Species: Homo sapiens
• Sequence 2: NP_524600.3
• Gene: CanA1 / 43670
• FlyBaseID: FBgn0010015
• Length: 622
• Species: Drosophila melanogaster
• Alignment Length: 528
• Identity: 371/528 - (70%)
• Similarity: 423/528 - (80%)
• Gaps: 30/528 - (5%)

Human    24 DRVVKAVPFPPTHRLTSEEVFD--LDGIPRVDVLKNHLVKEGRVDEEIALRIINEGAAILRREKT 86
            :|:|..||.||||:||..||:|  ..|.|..|.|:.|.:.|||::|.:|||||.||||:||.||.
  Fly    53 ERMVDDVPLPPTHKLTMSEVYDDPKTGKPNFDALRQHFLLEGRIEEAVALRIITEGAALLREEKN 117

Human    87 MIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWVLKILYPS 151
            ||:||||||||||||||||||:|||||||.||.||||||||||||||||||||||||.|||.||:
  Fly   118 MIDVEAPITVCGDIHGQFFDLVKLFEVGGPPATTRYLFLGDYVDRGYFSIECVLYLWSLKITYPT 182

Human   152 TLFLLRGNHECRHLTEYFTFKQECKIKYSERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIH 216
            ||.|||||||||||||||||||||.|||||.:|:|||||||.|||||||||||||:||||||||.
  Fly   183 TLSLLRGNHECRHLTEYFTFKQECIIKYSESIYDACMEAFDCLPLAALLNQQFLCIHGGLSPEIF 247

Human   217 TLDDIRRLDRFKEPPAFGPMCDLLWSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNN 281
            |||||:.|:||:||||:|||||||||||.|||||||:.|.||||:|||||||::|.|.|||||.|
  Fly   248 TLDDIKTLNRFREPPAYGPMCDLLWSDPLEDFGNEKTNEFFSHNSVRGCSYFFSYSACCEFLQKN 312

Human   282 NLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 346
            |||||:|||||||||||||||:|.|||||||||||||||||||||||||||||||||||||||||
  Fly   313 NLLSIVRAHEAQDAGYRMYRKNQVTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCS 377

Human   347 PHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDER------LIYGN--- 402
            ||||||||||||||||||||||||||||||:|:|||||||:...:|:.:|.      |:..|
  Fly   378 PHPYWLPNFMDVFTWSLPFVGEKVTEMLVNILNICSDDELVAGPDDELEEELRKKIVLVPANASN 442

Human   403 ---------KKVGSAAARKEIIRNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLAG 458
                     |....:|.|||||||||||||||:||||:|||||||||.||||||||.||.|.|:|
  Fly   443 NNNNNNTPSKPASMSALRKEIIRNKIRAIGKMSRVFSILREESESVLQLKGLTPTGALPVGALSG 507

Human   459 GRQTLQSATVEAIEAEKAIRGFSPPHRICSFEEAKGLDRINERMPPRKDAVQQDGFNSLNTAHAT 523
            ||.:|          ::|::|.:....|.||.||||||.:|||||||:..:.....:|:.|...:
  Fly   508 GRDSL----------KEALQGLTASSHIHSFAEAKGLDAVNERMPPRRPLLMSASSSSITTVTRS 562

Human   524 ENHGTGNH 531
            .:..:.|:
  Fly   563 SSSSSNNN 570

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CB	XP_047281382.1	MPP_PP2B	50..354	CDD:277361	254/303 (84%)
CanA1	NP_524600.3	MPP_PP2B	81..385	CDD:277361	254/303 (84%)