DRSC/TRiP Functional Genomics Resources

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Protein Alignment PPP3CA and ppp3ca

DIOPT Version :10

Sequence 1:NP_000935.1 Gene:PPP3CA / 5530 HGNCID:9314 Length:521 Species:Homo sapiens
Sequence 2:NP_001185479.1 Gene:ppp3ca / 794574 ZFINID:ZDB-GENE-091113-24 Length:521 Species:Danio rerio


Alignment Length:521 Identity:446/521 - (85%)
Similarity:481/521 - (92%) Gaps:13/521 - (2%)


- Green bases have known domain annotations that are detailed below.


Human     8 DPKLSTTDRVVKAVPFPPSHRLTAKEVFDNDGKPRVDILKAHLMKEGRLEESVALRIITEGASIL 72
            |..|::||||||:||||.|||||.|||||.:||||||:|||||.||||:||:||||||.||||||
Zfish     7 DMVLNSTDRVVKSVPFPLSHRLTMKEVFDCEGKPRVDLLKAHLTKEGRVEETVALRIINEGASIL 71

Human    73 RQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDRGYFSIECVLYLWALK 137
            ||||.:|||:|||||||||||||||||||||||||||.||||||||||||||||||||||||:||
Zfish    72 RQEKTMLDIEAPVTVCGDIHGQFFDLMKLFEVGGSPATTRYLFLGDYVDRGYFSIECVLYLWSLK 136

Human   138 ILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGL 202
            |||||||||||||||||||||||||||||||||||:|||:|||||||||||||||||||||||||
Zfish   137 ILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSEQVYDSCMDAFDCLPLAALMNQQFLCVHGGL 201

Human   203 SPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCE 267
            ||||.|||||:||||||||||:|||||:|||||||||||||:||:|:|||||||||||||||||:
Zfish   202 SPEIQTLDDIKKLDRFKEPPAFGPMCDLLWSDPLEDFGNEKSQEYFSHNTVRGCSYFYSYPAVCD 266

Human   268 FLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIR 332
            |||:||||||:||||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish   267 FLQNNNLLSIIRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIR 331

Human   333 QFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLNICSDDELGSEEDG-FDGATAAARKEVI 396
            |||||||||||||||||||||||||||||||||||||:|||||||.::.|. ||...||||||||
Zfish   332 QFNCSPHPYWLPNFMDVFTWSLPFVGEKVTEMLVNVLSICSDDELMNDGDEIFDANAAAARKEVI 396

Human   397 RNKIRAIGKMARVFSVLREESESVLTLKGLTPTGMLPSGVLSGGKQTLQSATVEAIEA------D 455
            |||||||||||::|||||||||:||||||||||||||||||:||||||||||:|||||      .
Zfish   397 RNKIRAIGKMAKMFSVLREESENVLTLKGLTPTGMLPSGVLAGGKQTLQSATIEAIEAIEEEEDT 461

Human   456 EAIKGFSPQHKITSFEEAKGLDRINERMPPRRDAMPSDANLNSINKALTSETNGTDSNGSNSSNI 520
            |||:||||||||:||||||||||||||||||:|.:....  :|:.|...|||||||.|    |||
Zfish   462 EAIRGFSPQHKISSFEEAKGLDRINERMPPRKDGVNHVG--HSMGKMNMSETNGTDDN----SNI 520

Human   521 Q 521
            |
Zfish   521 Q 521

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
PPP3CANP_000935.1 MPP_PP2B 41..345 CDD:277361 281/303 (93%)
Catalytic. /evidence=ECO:0000305 56..340 263/283 (93%)
SAPNY motif. /evidence=ECO:0000305|PubMed:26248042 307..311 3/3 (100%)
Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042 327..336 8/8 (100%)
Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402 341..369 27/27 (100%)
Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34 392..406 13/13 (100%)
Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298 407..414 4/6 (67%)
Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402 465..487 20/21 (95%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 475..521 25/45 (56%)
ppp3caNP_001185479.1 MPP_PP2B 40..344 CDD:277361 281/303 (93%)

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