Protein Alignment PPP3CA and Pp1-Y1

DIOPT Version :10

• Sequence 1: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_001104152.3
• Gene: Pp1-Y1 / 5740113
• FlyBaseID: FBgn0261399
• Length: 317
• Species: Drosophila melanogaster
• Alignment Length: 265
• Identity: 108/265 - (40%)
• Similarity: 158/265 - (59%)
• Gaps: 13/265 - (4%)

Human    58 ESVALRIITEGASILRQEKNLLDIDAPVTVCGDIHGQFFDLMKLFEVGGSPANTRYLFLGDYVDR 122
            ||..::::.:...:|..|..||.::|||.|.||||||:.||::.||..|.|...|||.|||||||
  Fly    37 ESDIIKLLKQARQVLMSEPMLLTVEAPVNVLGDIHGQYNDLLRYFETSGHPPKKRYLMLGDYVDR 101

Human   123 GYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQECKIKYSERVYDACMDAFDCLPL 187
            |.:|:|.:..|.|.|:.||.::.|||||||...:..|:.|..|||.:::.|::...:|.:||||:
  Fly   102 GKYSVETLTLLLAYKVRYPTSIHLLRGNHESAAINRYYGFYDECKRRFTIRLWRMFVDCYDCLPV 166

Human   188 AALMNQQFLCVHGGLSPEINTLDDIRKLDRFKEPPAYGPMCDILWSDPLEDFGNEKTQEHFTHNT 252
            ||::|.:..|.||||||.::.|:||:.|.|..|....|.:||:|||||      :.|...:..|:
  Fly   167 AAIINSKIFCCHGGLSPSLHNLNDIQHLQRPAEVDRNGLLCDLLWSDP------DPTAIGWEKNS 225

Human   253 VRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRKSQTTGFPSLITIFSAPNYLDVYNN 317
             ||.|:.:....|..||...:...|.|||:..:.||..:.|.|      |||:|||.||...::|
  Fly   226 -RGVSFTFGVDIVETFLSRFSFDLICRAHQVVEDGYEFFAKRQ------LITVFSAVNYCGEFDN 283

Human   318 KAAVL 322
            ..|::
  Fly   284 AGAMM 288

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	108/265 (41%)
		Catalytic. /evidence=ECO:0000305	56..340		108/265 (41%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		2/3 (67%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521
Pp1-Y1	NP_001104152.3	MPP_superfamily	17..303	CDD:472684	108/265 (41%)