Protein Alignment PPP3CA and PpD3

DIOPT Version :10

• Sequence 1: NP_000935.1
• Gene: PPP3CA / 5530
• HGNCID: 9314
• Length: 521
• Species: Homo sapiens
• Sequence 2: NP_524946.1
• Gene: PpD3 / 49779
• FlyBaseID: FBgn0005777
• Length: 520
• Species: Drosophila melanogaster
• Alignment Length: 374
• Identity: 133/374 - (35%)
• Similarity: 191/374 - (51%)
• Gaps: 54/374 - (14%)

Human     4 PKAIDPKLSTTD--RVVK--------AVPFPPSHRLTAKEVFDN----------------DGKPR 42
            |...|.||..|:  ::||        ||..|..   |..|::.:                |||..
  Fly   148 PNDKDAKLKFTECNKIVKMRAFERAIAVDKPEK---TLSEMYSDMENITIEDDYKGPQLEDGKVT 209

Human    43 VDILK---AHLMKEGRLEESVALRIITEGASILRQEKNLLDIDAP----VTVCGDIHGQFFDLMK 100
            :..:|   .|...:.||....|.:|:.|..:.:|.:.:|:||..|    .|:||||||||:|||.
  Fly   210 LKFMKELMEHYKAQKRLHRKFAYKILCEIDTYMRAQPSLVDITVPDEEKFTICGDIHGQFYDLMN 274

Human   101 LFEVGGSPANTR-YLFLGDYVDRGYFSIECVLYLWALKILYPKTLFLLRGNHECRHLTEYFTFKQ 164
            :||:.|.|:... |||.||:||||.||:||:..|:..|:|||...||.|||||..::.:.:.|..
  Fly   275 IFEINGLPSEKNPYLFNGDFVDRGSFSVECIFTLFGFKLLYPNHFFLARGNHESINMNQMYGFTG 339

Human   165 ECKIKYSERVYDACMDAFDCLPLAALMNQQFLCVHGGL-SPEINTLDDIRKLDRFKEPPAYGPMC 228
            |...||:..:.|.....|:.|||...:||:.|.:|||| |.|..|||.||:::|..:||..|.||
  Fly   340 EVTAKYTSAMADIFTQVFNWLPLCHCINQKILVMHGGLFSTEDVTLDHIRRIERNCQPPEEGLMC 404

Human   229 DILWSDPLEDFGNEKTQEHFTHNTVRGCSYFYSYPAVCEFLQHNNLLSILRAHEAQDAGYRMYRK 293
            ::|||||.:..|..:::        ||....:......:|.:.|||..|:|:||.:|.||.:...
  Fly   405 ELLWSDPQQWMGLGQSK--------RGVGIQFGPDVTEKFCKDNNLDYIIRSHEVKDMGYEVAHN 461

Human   294 SQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVM--NIRQFNCSPHP 340
            .:      .||:||||||.|...|..|.:....|.:  |.:.|...|||
  Fly   462 GK------CITVFSAPNYCDTMGNMGAFITITGNNLKPNYKSFEAVPHP 504

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
PPP3CA	NP_000935.1	MPP_PP2B	41..345	CDD:277361	118/311 (38%)
		Catalytic. /evidence=ECO:0000305	56..340		113/291 (39%)
		SAPNY motif. /evidence=ECO:0000305|PubMed:26248042	307..311		3/3 (100%)
		Interaction with PxIxIF motif in substrate. /evidence=ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:17502104, ECO:0000269|PubMed:22343722, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:26248042	327..336		3/10 (30%)
		Calcineurin B binding. /evidence=ECO:0000269|PubMed:12218175, ECO:0000269|PubMed:12357034, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:23468591, ECO:0000269|PubMed:27974827, ECO:0000269|PubMed:8524402	341..369		133/374 (36%)
		Calmodulin-binding. /evidence=ECO:0000269|PubMed:18384083, ECO:0000269|PubMed:19404396, ECO:0000269|PubMed:25144868, ECO:0000269|Ref.34	392..406
		Autoinhibitory segment. /evidence=ECO:0000250|UniProtKB:P16298	407..414
		Autoinhibitory domain. /evidence=ECO:0000269|PubMed:8524402	465..487
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	475..521
PpD3	NP_524946.1	3a0801s09	7..>140	CDD:273380
		TPR repeat	49..77	CDD:276809
		TPR repeat	82..112	CDD:276809
		MPP_PP5_C	198..513	CDD:277362	121/321 (38%)